Evidence map›Paper›PMID 38414795›Full record

ArticleRegenerative biomaterials2024

Enhancing cartilage regeneration and repair through bioactive and biomechanical modification of 3D acellular dermal matrix.

Wei Gao, Tan Cheng, Zhengya Tang, Wenqiang Zhang, Yong Xu, Min Han, Guangdong Zhou, Chunsheng Tao, Ning Xu, Huitang Xia and 1 more

Abstract read
In one paragraph

Article in Regenerative biomaterials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Enhancing the maturity ofRegenerative biomaterials · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wei GaoQingdao Medical College of Qingdao University, Qingdao, 266071, China.
Tan ChengDepartment of Cardiothoracic Surgery, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200040, China.
Zhengya TangDepartment of Plastic surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200023, China.
Wenqiang ZhangDepartment of Orthopaedics, The First Affiliated Hospital of Shandong First Medical University, Jinan, 266299, China.
Yong XuDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, China.ORCID https://orcid.org/0000-0001-5599-8611
Min HanDepartment of Orthopedic Surgery, Shanghai Eighth People's Hospital, Shanghai, 200235, China.
Guangdong ZhouDepartment of Plastic surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200023, China.
Chunsheng TaoDepartment of Orthopaedics, Ninety-seventh Hospital of the Chinese People's Liberation Army Navy, Qingdao, 266071, China.ORCID https://orcid.org/0000-0001-8547-4296
Ning XuDepartment of Orthopaedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Huitang XiaDepartment of Plastic Surgery & Jinan Clinical Research Center for Tissue Engineering Skin Regeneration and Wound Repair, The First Affiliated Hospital of Shandong First Medical University, Jinan, 266299, China.
Weijie SunDepartment of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Shushan, Hefei, 230022, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acellular dermal matrix (ADM) shows promise for cartilage regeneration and repair. However, an effective decellularization technique that removes cellular components while preserving the extracellular matrix, the transformation of 2D-ADM into a suitable 3D scaffold with porosity and the enhancement of bioactive and biomechanical properties in the 3D-ADM scaffold are yet to be fully addressed. In this study, we present an innovative decellularization method involving 0.125% trypsin and 0.5% SDS and a 1% Triton X-100 solution for preparing ADM and converting 2D-ADM into 3D-ADM scaffolds. These scaffolds exhibit favorable physicochemical properties, exceptional biocompatibility and significant potential for driving cartilage regeneration

Indexed as

acellular dermal matrixcalcium sulfate hemihydratecartilage regenerationsmall intestinal submucosathree-dimensional scaffolds

Identifiers

PMID38414795
PMCPMC10898337

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.