ReviewBiomedical reports2024
Neurobiology of bruxism: The impact of stress (Review).
Review in Biomedical reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Management of awake bruxism: a systematic review.BMC oral health · 2026Pooled it
- Is bruxism associated with the use of screen devices in children and adolescents? A systematic review.Brazilian oral research · 2026Pooled it
- Association between attention deficit hyperactivity disorder and bruxism: a systematic review.Frontiers in psychiatry · 2026Pooled it
- The relationship between psychological factors and temporomandibular disorders: a systematic review and meta-analysis.Head & face medicine · 2025Pooled it
- The Oral-Brain Axis: A Unified Framework Linking Trigeminal Sensorimotor Dysfunction, Chronic Stress, Neuroinflammation, and Neurodegeneration.International journal of molecular sciences · 2026Review
- Assessing patient awareness of bruxism before dental implant therapy.Scientific reports · 2026Observational
- Muscle Tone Regulation and Bruxism in Chronic Stress: Pathophysiological Links to Tooth Fractures and Dental Hard Tissue Pathology.Medical sciences (Basel, Switzerland) · 2026Review
- Psychological and somatosensory correlates of temporomandibular disorder: anxiety, somatosensory amplification, and coping strategies-a biopsychosocial perspective.Journal of oral & facial pain and headache · 2026Article
- Psychological Features Associated With Awake Bruxism in Painful TMD: The Role of Anxiety.Journal of oral rehabilitation · 2026Article
- Daytime Sleepiness and Dispositional Optimism Are Related to Awake Bruxism Among Patients With Painful Temporomandibular Disorders.Journal of oral rehabilitation · 2026Article
- Sleep bruxism and daily life behaviors in university students: a cross-sectional analysis of free time management, sedentary behaviors, and smartphone use.BMC oral health · 2026Article
- Temporal patterns of bruxism behaviors: multiple day recording with portable electromyography.Scientific reports · 2026Article
- Stress-, Anxiety-, and Gender-Related Modulation of Masseter Muscle Activity During Wakefulness.Journal of oral rehabilitation · 2026Article
- The role of affective temperaments on depressive rumination in individuals with bruxism.AIMS public health · 2026Article
- Sleep bruxism: a novel theoretical perspective through the lens of the free energy principle (FEP).Frontiers in behavioral neuroscience · 2026Article
- The mesencephalic trigeminal neuron: electrophysiological insights into function and dysfunction.Frontiers in cellular neuroscience · 2026Review
- Education-Related Stress and Its Behavioral and Somatic Manifestations Among Dental Students: A Cross-Sectional Analysis of Bruxism and Temporomandibular Symptoms.Healthcare (Basel, Switzerland) · 2025Article
- Prevalence of Bruxism Among Young Adult Energy Drink Consumers in Jordan.Journal of clinical medicine · 2025Article
- Functional Effects of BoNT-A Application in Masseter Muscle in Patients with Symptoms of Bruxism.Toxins · 2025Article
- Assessment of Common Oral Behaviors in Patients with Temporomandibular Joint Disorders and Their Relationship to Psychosocial Factors.Dentistry journal · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bruxism is a non-functional involuntary muscle activity that affects more than one-third of the population at some point in their lives. A number of factors have been found to be related to the etiopathogenesis of bruxism; therefore, the condition is considered multifactorial. The most commonly accepted factor is stress. Stress has long been considered to increase muscle tone and to reduce the pain threshold. Current evidence indicates that exposure to chronic stress, distress and allostatic load ignite neurological degeneration and the attenuation of critical neuronal pathways that are highly implicated in the orofacial involuntary muscle activity. The present review discusses the negative effects that chronic stress exerts on certain parts of the central nervous system and the mechanisms through which these changes are involved in the etiopathogenesis of bruxism. The extent of these morphological and functional changes on nerves and neuronal tracts provides valuable insight into the obstacles that need to be overcome in order to achieve successful treatment. Additionally, particular emphasis is given on the effects of bruxism on the central nervous system, particularly the activation of the hypothalamic-pituitary-adrenal axis, as this subsequently induces an increase in circulating corticosterone levels, also evidenced by increased levels of salivary cortisol, thereby transforming bruxism into a self-reinforcing loop.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.