Evidence map›Paper›PMID 38414622›Full record

ArticleFrontiers in medicine2024

Severe, very early onset preeclampsia in a Covid 19-positive woman with a twin pregnancy presenting with a hydatidiform mole and coexisting normal fetus: a case report.

Daniela Willy, Ralf Schmitz, Mareike Möllers, Barbara Heitplatz, Anna Kuntze, Yvonne Stratis, Katrin Bahlke, Albrecht Röpke, Matthias Meyer-Wittkopf, Kathrin Oelmeier

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Daniela WillyDepartment of Gynecology and Obstetrics, University Hospital Münster, Münster, Germany.
Ralf SchmitzDepartment of Gynecology and Obstetrics, University Hospital Münster, Münster, Germany.
Mareike MöllersDepartment of Gynecology and Obstetrics, University Hospital Münster, Münster, Germany.
Barbara HeitplatzGerhard-Domagk-Institute of Pathology, University Hospital Münster, Münster, Germany.
Anna KuntzeGerhard-Domagk-Institute of Pathology, University Hospital Münster, Münster, Germany.
Yvonne StratisInstitute of Human Genetics, University Hospital Münster, Münster, Germany.
Katrin BahlkeInstitute of Human Genetics, University Hospital Münster, Münster, Germany.
Albrecht RöpkeInstitute of Human Genetics, University Hospital Münster, Münster, Germany.
Matthias Meyer-WittkopfDepartment of Prenatal Diagnostics, Mathias-Spital Rheine, Rheine, Germany.
Kathrin OelmeierDepartment of Gynecology and Obstetrics, University Hospital Münster, Münster, Germany.
University Hospital Münster · DEKlinikum Rheine · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cases of hydatidiform moles with a coexisting fetus are sparse and patients are at high risk for severe complications. Patients and physicians often face the dilemma of the wish to continue pregnancy until viability of the fetus while the risk for maternal complications increases. We present an educational case of a twin pregnancy presenting with a hydatidiform mole and coexisting normal fetus with a placenta praevia. The patient developed severe, early onset preeclampsia with beginning HELLP-syndrome and was tested Covid-19 positive in the further course. Termination of pregnancy was conducted via caesarean section at 18 + 6 weeks of pregnancy. Histopathology and genetic analysis confirmed a complete hydatidiform mole next to a normal placenta. Close follow-up examinations were conducted and showed normal findings including ß HCG levels normalizing within 5 months. This case combines several rare, difficult and severe medical conditions and demonstrates how an individualized therapy by an interdisciplinary team covering a highly sensitive topic was developed in a situation where no guidelines exist.

Indexed as

case reportcomplete molegestational trophoblastic diseasehydatidiform molepreeclampsia

Identifiers

PMID38414622
PMCPMC10896921
OpenAlexW4391783774

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.