ArticleWorld journal of clinical cases2024
Causal associations between gastroesophageal reflux disease and essential hypertension: A bidirectional Mendelian randomization study.
Article in World journal of clinical cases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 6 citations in OpenAlex.
- Genetic evidence linking gastroesophageal reflux disease to chronic kidney disease and kidney failure: a two-step Mendelian randomization study.Renal failure · 2025Article
- Association between exposure to proton pump inhibitors and hypertension: a descriptive and disproportionality analysis of VigiBase.BMJ open · 2025Article
- The association of Gastro-esophageal reflux disease and self-reported myocardial-infarction among World Trade Center disaster exposed persons.Preventive medicine reports · 2025Article
- A Phenome-Wide Mendelian Randomization and Colocalization Study Reveals Genetic Association Between PBC and Other Autoimmune Disorders.Canadian journal of gastroenterology & hepatology · 2025Article
- Article
- Investigating causal links between gastroesophageal reflux disease and essential hypertension.World journal of clinical cases · 2024Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClinical studies have reported that patients with gastroesophageal reflux disease (GERD) have a higher prevalence of hypertension.
aimTo performed a bidirectional Mendelian randomization (MR) analysis to investigate the causal link between GERD and essential hypertension.
methodsEligible single nucleotide polymorphisms (SNPs) were selected, and weighted median, inverse variance weighted (IVW) as well as MR egger (MR-Egger) regression were used to examine the potential causal association between GERD and hypertension. The MR-Pleiotropy RESidual Sum and Outlier analysis was used to detect and attempt to reduce horizontal pleiotropy by removing outliers SNPs. The MR-Egger intercept test, Cochran's
resultsIVW analysis exhibited an increased risk of hypertension (OR = 1.46, 95%CI: 1.33-1.59,
conclusionWe found that GERD would increase the risk of essential hypertension, which provided a novel prevent and therapeutic perspectives of essential hypertension.
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