ArticlePsychiatry and clinical neurosciences2024
Associations of conservatism and jumping to conclusions biases with aberrant salience and default mode network.
Article in Psychiatry and clinical neurosciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 8 citations in OpenAlex.
- Aberrant salience is selectively associated with ventral midbrain connectivity to the dorsal but not ventral striatum.Schizophrenia (Heidelberg, Germany) · 2026Article
- Disrupted Salience Network and Its Deteriorated Interaction With the Central Executive Network in Anorexia Nervosa: A Multicenter Study.Biological psychiatry global open science · 2026Article
- Jumping to conclusions bias in early psychosis: Relationships with symptom dimensions, neurocognition and social cognition.Schizophrenia research. Cognition · 2026Article
- Default Mode Network, Disorganization, and Treatment-Resistant Schizophrenia.Schizophrenia bulletin · 2026Article
- Predicting models for work outcomes in patients with schizophrenia and its clinical application.Scientific reports · 2025Article
- Energy landscape analysis based on the Ising model: Tutorial review.PLOS complex systems · 2025Article
- Computational modeling of visual salience alteration and its application to eye-movement data.Frontiers in neuroscience · 2025Article
- Altered cortical-striatal circuits connectivity is associated with psychotic symptoms in patients with first-episode, drug-naïve early-onset schizophrenia.Frontiers in psychiatry · 2025Article
- Energy of Functional Brain States Correlates With Cognition in Adolescent-Onset Schizophrenia and Healthy Persons.Human brain mapping · 2025Article
Corrections and comments
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Authors and funding
14 authors at 8 institutions in 2 countries.
Funding
Abstract
aimWhile conservatism bias refers to the human need for more evidence for decision-making than rational thinking expects, the jumping to conclusions (JTC) bias refers to the need for less evidence among individuals with schizophrenia/delusion compared to healthy people. Although the hippocampus-midbrain-striatal aberrant salience system and the salience, default mode (DMN), and frontoparietal networks ("triple networks") are implicated in delusion/schizophrenia pathophysiology, the associations between conservatism/JTC and these systems/networks are unclear.
methodsThirty-seven patients with schizophrenia and 33 healthy controls performed the beads task, with large and small numbers of bead draws to decision (DTD) indicating conservatism and JTC, respectively. We performed independent component analysis (ICA) of resting functional magnetic resonance imaging (fMRI) data. For systems/networks above, we investigated interactions between diagnosis and DTD, and main effects of DTD. We similarly applied ICA to structural and diffusion MRI to explore the associations between DTD and gray/white matter.
resultsWe identified a significant main effect of DTD with functional connectivity between the striatum and DMN, which was negatively correlated with delusion severity in patients, indicating that the greater the anti-correlation between these networks, the stronger the JTC and delusion. We further observed the main effects of DTD on a gray matter network resembling the DMN, and a white matter network connecting the functional and gray matter networks (all P < 0.05, family-wise error [FWE] correction). Function and gray/white matter showed no significant interactions.
conclusionOur results support the novel association of conservatism and JTC biases with aberrant salience and default brain mode.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.