Evidence map›Paper›PMID 38414031›Full record

ArticleJournal of nanobiotechnology2024

Inhalable hybrid nanovaccines with virus-biomimetic structure boost protective immune responses against SARS-CoV-2 variants.

Shuqi Wang, Peiyang Ding, Lingli Shen, Daopeng Fan, Hanghang Cheng, Jian Huo, Xin Wei, Hua He, Gaiping Zhang

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Advances in Inhaled Nanoparticle Drug Delivery for Pulmonary Disease Management.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Shuqi Wang *College of Veterinary Medicine, International Joint Research Center of National Animal Immunology, Henan Agricultural University, Zhengzhou, 450046, China.
Peiyang Ding *School of Life Science, Zhengzhou University, Zhengzhou, 450046, China.
Lingli ShenCollege of Veterinary Medicine, International Joint Research Center of National Animal Immunology, Henan Agricultural University, Zhengzhou, 450046, China.
Daopeng FanCollege of Veterinary Medicine, International Joint Research Center of National Animal Immunology, Henan Agricultural University, Zhengzhou, 450046, China.
Hanghang ChengCollege of Veterinary Medicine, International Joint Research Center of National Animal Immunology, Henan Agricultural University, Zhengzhou, 450046, China.
Jian HuoCollege of Veterinary Medicine, International Joint Research Center of National Animal Immunology, Henan Agricultural University, Zhengzhou, 450046, China.
Xin WeiJoint National Laboratory for Antibody Drug Engineering, Henan University, Kaifeng, 475004, China.
Hua HeCollege of Veterinary Medicine, International Joint Research Center of National Animal Immunology, Henan Agricultural University, Zhengzhou, 450046, China. hhe@henau.edu.cn.
Gaiping ZhangCollege of Veterinary Medicine, International Joint Research Center of National Animal Immunology, Henan Agricultural University, Zhengzhou, 450046, China. zhanggaip@126.com.
Henan Agricultural University · CNHenan University · CNZhengzhou University · CN

Funding

the Key Projects of Science and Technology of Henan Province 221100110600the National Natural Science Foundation of China 51903074the Young TopNotch Talents Foundation of Henan Agricultural University 30500737
6 · The paper itself

Abstract

backgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with different antigenic variants, has posed a significant threat to public health. It is urgent to develop inhalable vaccines, instead of injectable vaccines, to elicit mucosal immunity against respiratory viral infections.

methodsWe reported an inhalable hybrid nanovaccine (NV

resultsIn contrast to subcutaneous vaccination, NV

conclusionsThis inhalable NV

Indexed as

COVID-19SARS-CoV-2AnimalsAntibodies, NeutralizingAntibodies, ViralBiomimeticsHumansImmunity, MucosalMiceNanovaccinesAntibodies, NeutralizingAntibodies, ViralNanovaccinesBroad-spectrum neutralization activityGenetically engineered nanovesiclesInhalable hybrid nanovaccineMucosal immunitySARS-CoV-2Virus-biomimetic structure

Identifiers

PMID38414031
PMCPMC10898168
OpenAlexW4392194564

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.