Evidence map›Paper›PMID 38413986›Full record

Trial reportClinical epigenetics2024

Improvements in lung function following vitamin C supplementation to pregnant smokers are associated with buccal DNA methylation at 5 years of age.

Lyndsey E Shorey-Kendrick, Cindy T McEvoy, Kristin Milner, Julia Harris, Julie Brownsberger, Robert S Tepper, Byung Park, Lina Gao, Annette Vu, Cynthia D Morris and 1 more

Erratum issued 2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical epigenetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01723696 phase2 / phase3completednot on this map

Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function

TypeinterventionalSponsorOregon Health and Science UniversityRan2012 to 2017Enrolled252ConditionsPulmonary Function, Newborn, Abnormal, Infant Wheeze, In-utero NicotineArmsVitamin C +prenatal vitamin, Placebo tablet+prenatal vitamin
NCT03203603 completednot on this map

Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP): Follow-up of a Randomized Trial

TypeobservationalSponsorOregon Health and Science UniversityRan2017 to 2024Enrolled242ConditionsAsthma, Pulmonary Function, Wheezing, In Utero NicotineArmsNo active intervention
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Lyndsey E Shorey-KendrickDivision of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, 97006, USA. shorey@ohsu.edu.
Cindy T McEvoyDepartment of Pediatrics, Pape Pediatric Research Institute, Oregon Health and Science University, Portland, OR, USA.
Kristin MilnerDepartment of Pediatrics, Oregon Health and Science University, Portland, OR, USA.
Julia HarrisDepartment of Pediatrics, Oregon Health and Science University, Portland, OR, USA.
Julie BrownsbergerDepartment of Pediatrics, Oregon Health and Science University, Portland, OR, USA.
Robert S TepperDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.
Byung ParkBiostatistics Shared Resources, Knight Cancer Institute, Bioinformatics and Biostatistics Core, Oregon National Primate Research Center, Oregon Health and Science University, Portland State University School of Public Health, Portland, OR, USA.
Lina GaoBiostatistics Shared Resources, Knight Cancer Institute, Bioinformatics and Biostatistics Core, Oregon National Primate Research Center, Oregon Health and Science University, Portland State University School of Public Health, Portland, OR, USA.
Annette VuOregon Clinical & Translational Research Institute, Oregon Health and Science; Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, OR, USA.
Cynthia D MorrisOregon Clinical & Translational Research Institute, Oregon Health and Science; Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, OR, USA.
Eliot R SpindelDivision of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, 97006, USA.
Oregon Health & Science University · USOregon National Primate Research Center · USIndiana University – Purdue University Indianapolis · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Oregon Clinical and Translational Research InstituteUL1TR000128 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLISON, DAVID H · 2012 to 2015
$28.7M
Maternal vitamin C supplementation to decrease effects of smoking during pregnancy on infant lung function and health:Follow-up of 2 randomized trials and association with changes in DNA methylationUH3OD023288 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia T McEvoy, ELIOT R SPINDEL · 2018 to 2026
$12.1M
VitC to Decrease Effects of Smoking in Pregnancy on Infant Lung Function-CCC-LeadR01HL105447 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI MCEVOY, CYNTHIA T · 2012 to 2021
$9.8M
NCATS NIH HHS UL1 TR000128NCATS NIH HHS UL1TR000128NHLBI NIH HHS R01 HL105447NIH HHS P51 OD011092NIH HHS UH3 OD023288ODCDC CDC HHS UH3 OD023288
6 · The paper itself

Abstract

backgroundWe previously reported in the "Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function" randomized clinical trial (RCT) that vitamin C (500 mg/day) supplementation to pregnant smokers is associated with improved respiratory outcomes that persist through 5 years of age. The objective of this study was to assess whether buccal cell DNA methylation (DNAm), as a surrogate for airway epithelium, is associated with vitamin C supplementation, improved lung function, and decreased occurrence of wheeze.

methodsWe conducted epigenome-wide association studies (EWAS) using Infinium MethylationEPIC arrays and buccal DNAm from 158 subjects (80 placebo; 78 vitamin C) with pulmonary function testing (PFT) performed at the 5-year visit. EWAS were performed on (1) vitamin C treatment, (2) forced expiratory flow between 25 and 75% of expired volume (FEF

resultsVitamin C treatment was associated with 457 FDR significant (q < 0.05) differentially methylated CpGs (DMCs; 236 hypermethylated; 221 hypomethylated) and 53 differentially methylated regions (DMRs; 26 hyper; 27 hypo) at 5 years of age. FEF

conclusionsVitamin C supplementation to pregnant smokers is associated with buccal DNA methylation in offspring at 5 years of age, and most methylation signatures appear to be persistent from the prenatal period. Buccal methylation at 5 years was also associated with current lung function and occurrence of wheeze, and these functionally associated loci are enriched for vitamin C associated loci. Clinical trial registration ClinicalTrials.gov, NCT01723696 and NCT03203603.

Indexed as

Ascorbic AcidDNA MethylationSmokersVitaminsChild, PreschoolDietary SupplementsFemaleHumansInfantLungMaternal Nutritional Physiological PhenomenaPregnancyRespiratory SoundsAscorbic AcidVitaminsAirwayDNA methylationLung functionMethylationEPICMSDP: maternal smoking during pregnancyNicotineRCT: randomized clinical trialVitamin CWheeze

Identifiers

PMID38413986
PMCPMC10900729
OpenAlexW4392200356

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.