ArticleBMC geriatrics2024
Association between physical frailty, circadian syndrome and cardiovascular disease among middle-aged and older adults: a longitudinal study.
Article in BMC geriatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Dental Caries Experience in Older Adults With Parkinson's Disease: A Systematic Review and Meta-Analysis.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric DentistryPooled it
- Interrelationship Between Sarcopenia, Frailty and Cardiovascular Disease-The Crucial Role of Obesity in Hypothesis Generation-A Narrative Review.Journal of personalized medicine · 2026Review
- Associations between multiple metabolic indices and circadian syndrome: a cross-sectional study with mediation analysis of the C-reactive protein triglyceride glucose index.Hormones (Athens, Greece) · 2026Article
- Frailty and Cardiovascular Events as Determined by Body Composition: A Systematic Review.Chronic diseases and translational medicine · 2026Review
- The role of instrumental activity of daily living disability in the association between circadian syndrome and cardiometabolic multimorbidity in Chinese middle-aged and older adults.Journal of health, population, and nutrition · 2025Article
- Cross-sectional and longitudinal relationships between COVID-19 stressors and depressive symptoms across sex and age groups: findings from the Canadian longitudinal study on aging.Epidemiology and psychiatric sciences · 2025Article
- Association of circadian-metabolic syndrome with incident chronic liver disease in middle-aged and elderly Chinese adults: a prospective cohort study on mediation by cardiovascular disease.European journal of medical research · 2025Article
- Sleep and Stroke-An Overlooked Bidirectional Influence: Why Should Sleep and Vascular Neurologists Work Closer?Journal of clinical medicine · 2025Article
- Assessment of relationships between frailty and diabetes: A two-sample Mendelian randomization study.The Journal of international medical research · 2025Article
- Frailty and depressive symptoms in relation to cardiovascular disease risk in middle-aged and older adults.Nature communications · 2025Article
- The mediating role of the TyG index in the relationship between circadian syndrome and cancer among middle-aged and elderly Chinese.BMC cancer · 2025Article
- The relationship between frailty and major adverse cardiovascular and cerebrovascular events in Chinese older adults: the mediating effect of lipid accumulation products.Archives of public health = Archives belges de sante publique · 2025Article
- Evaluation of Joint Effect of Frailty and Sleep Health on Cardiometabolic Multimorbidity in Aging Population.Nature and science of sleep · 2025Article
- Investigating the association between social participation and all-cause mortality risk among Chinese middle-aged and older adults.Frontiers in public health · 2025Article
- The association between circadian syndrome and possible sarcopenia in an aging population: A 4-year follow-up study.PloS one · 2025Article
- Gender and activity disparities in the relationship between circadian syndrome and gallstone disease.Frontiers in endocrinology · 2024Article
- Epidemiological Burden of Otitis Media Among U.S. Males: Trends, Risk Factors, and Public Health Implications.American journal of men's healthArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPhysical frailty (PF) and circadian syndrome (CircS) are proposed as novel risks for cardiovascular disease (CVD), but little attention is paid to their combined impact on CVD. This study aimed to investigate the association of PF, CircS and CVD in middle-aged and older adults.
methodsThe sample comprised 8512 participants aged at least 45 years from the China Health and Retirement Longitudinal Study (CHARLS) 2011. PF was examined by the physical frailty phenotype scale. CircS was assessed by the components of the International Diabetes Federation (IDF) MetS plus short sleep duration and depression. The cut-off for CircS was set as ≥ 4. CVD was defined as the presence of physician-diagnosed heart disease and/or stroke. A total of 6176 participants without CVD recruited from CHARLS 2011 and were followed up in 2018.
resultsThe prevalence of CVD in total populations, neither CircS or PF, PF alone, CircS alone and both CircS and PF were 13.0%, 7.4%, 15.5%, 17.4%, and 30.2%, respectively. CircS was more likely to be PF [OR (95%CI): 2.070 (1.732 ∼ 2.472)] than those without CircS. Both CircS alone [OR (95% CI): 1.954 (1.663 ∼ 2.296)], and coexisting CircS and PF [3.508 (2.739 ∼ 4.494)] were associated with CVD. Longitudinal analysis showed that individuals with both CircS and PF (HR: 1.716, 95%CI: 1.314 ∼ 2.240) and CircS alone [1.520 (1.331 ∼ 1.737)] were more likely to have new onset CVD than neither CircS or PF peers.
conclusionPF and CircS together are associated with higher CVD risk, which provided new evidence for a strong relation that warrants attention to assessing PF and CircS and in community to promote healthy aging.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.