ArticleNature metabolism2024
Histone butyrylation in the mouse intestine is mediated by the microbiota and associated with regulation of gene expression.
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Article in Nature metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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0cells of the map it votes in
37citing papers in PubMed
10.5field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 45 citations in OpenAlex.
- Dynamic regulation of H3K9 modifications in cancer: pathogenesis and targeted therapies.Biomarker research · 2026Review
- Marine-Derived Proteins: Individual Variability in Health Effects Across Protein Structure, Host Genetics, and Gut Microbiota.Comprehensive reviews in food science and food safety · 2026Review
- Novel protein acylations in Alzheimer's disease: Molecular, mechanisms, biological significance, and diagnostic and therapeutic potentials.Journal of advanced research · 2026Review
- The impact of microbial metabolites on host chromatin and epigenetic regulation.Nature metabolism · 2026Review
- Nuclear-specific reductive carboxylation of alpha-ketoglutarate fuels histone acetylation to induce chromatin accessibility and gene activation.Nature communications · 2026Article
- Coming to light: the transcriptional regulatory roles of histone lysine crotonylation in health and disease.Cellular & molecular biology letters · 2026Review
- Lysine Propionylation as a Metabolically Coupled PTM: Mechanisms, Functional Consequences, and Therapeutic Potentials.International journal of molecular sciences · 2026Review
- Butyrate extends health and lifespan in mice with mitochondrial deficiency.Nature communications · 2026Article
- Targeting metabolic-epigenetic-immune axis in cancer: molecular mechanisms and therapeutic implications.Signal transduction and targeted therapy · 2026Review
- Review
- Butyrate extends health and lifespan in mice with mitochondrial deficiency.bioRxiv : the preprint server for biology · 2026Article
- Gut microbiota-epigenetic interactions in systemic aging: mechanistic drivers for endocrine and reproductive network remodeling and therapeutic modulation.Frontiers in aging · 2026Review
- Transient short-chain fatty acid exposure and the temporal question of epithelial barrier immunity.Frontiers in immunology · 2026Review
- The interplay of the microbiome, host genetics, and epigenetic modifications in gastric cancer.Frontiers in microbiology · 2026Review
- Integrative profiling of diverse post-translational modifications for prognostic stratification and personalized therapy in papillary thyroid cancer.Frontiers in endocrinology · 2026Article
- Article
- Fermentation-driven interactions of gut microbes with their environment.Essays in biochemistry · 2025Review
- Protein crotonylation in cancer: mechanisms, functions, and therapeutic potential.Cell biology and toxicology · 2025Review
- Gut microbiota and epigenetic inheritance: implications for the development of IBD.Gut microbes · 2025Review
- Protein acylation in inflammatory diseases: from mechanisms to therapeutic strategies.Cell communication and signaling : CCS · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 1 country.
Leah A GatesLaboratory of Chromatin Biology & Epigenetics, The Rockefeller University, New York, NY, USA. leah.gates@case.edu.ORCID http://orcid.org/0000-0001-6850-8167
Bernardo Sgarbi ReisLaboratory of Mucosal Immunology, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0002-6841-116X
Peder J LundDepartment of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-2146-8724
Matthew R PaulBioinformatics Resource Center, The Rockefeller University, New York, NY, USA.
Marylene LeboeufLaboratory of Chromatin Biology & Epigenetics, The Rockefeller University, New York, NY, USA.
Annaelle M DjomoLaboratory of Chromatin Biology & Epigenetics, The Rockefeller University, New York, NY, USA.
Zara NadeemLaboratory of Chromatin Biology & Epigenetics, The Rockefeller University, New York, NY, USA.
Mariana LopesDepartment of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-1810-9798
Francisca N VitorinoDepartment of Biochemistry and Molecular Biophysics, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-8543-2299
Gokhan UnluLaboratory of Metabolic Regulation & Genetics, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0002-2704-2724
Thomas S CarrollBioinformatics Resource Center, The Rockefeller University, New York, NY, USA.
Kivanç BirsoyLaboratory of Metabolic Regulation & Genetics, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0002-7579-9895
Benjamin A GarciaDepartment of Biochemistry and Molecular Biophysics, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Daniel MucidaLaboratory of Mucosal Immunology, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0002-0000-0452
C David AllisLaboratory of Chromatin Biology & Epigenetics, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0001-7589-713X
Rockefeller University · USWashington University in St. Louis · USCase Western Reserve University · USHunter College · US
Funding
IMMUNOBIOLOGY OF NORMAL AND NEOPLASTIC LYMPHOCYTEST32CA009140 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Malay Haldar, WARREN S PEAR · 1985 to 2026
$16.1MThe Cleveland Digestive Diseases Research Core Center (DDRCC)P30DK097948 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Theresa Torres Pizarro · 2015 to 2026
$15.6MViral modulation of epitranscriptomic mechanismsR01AI118891 · NIAID · WASHINGTON UNIVERSITY · PI GARCIA, BENJAMIN A, WEITZMAN, MATTHEW D. · 2015 to 2025
$5.4MQuantitative mass spectrometry for comprehending epigenetic mechanisms in a new underlying neurological developmental disorderR01HD106051 · NICHD · WASHINGTON UNIVERSITY · PI Benjamin A Garcia · 2022 to 2026
$2.6MIntegration of metabolism and chromatin in regulating gene expression in vivoR00GM143550 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI Leah Ashley Gates · 2024 to 2026
$747kIntegration of metabolism and chromatin in regulating gene expression in vivoK99GM143550 · NIGMS · ROCKEFELLER UNIVERSITY · PI GATES, LEAH ASHLEY · 2021 to 2022
$200kThe impact of microbial metabolites on the chromatin landscape and gene regulationF32GM134560 · NIGMS · ROCKEFELLER UNIVERSITY · PI GATES, LEAH ASHLEY · 2019 to 2020
$132kCrohn's and Colitis Foundation (Crohn's & Colitis Foundation) RFA 598467NCI NIH HHS T32 CA009140NIAID NIH HHS R01 AI118891NICHD NIH HHS R01 HD106051NIDDK NIH HHS P30 DK097948NIGMS NIH HHS F32 GM134560NIGMS NIH HHS K99 GM143550NIGMS NIH HHS R00 GM143550U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01HD106051U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI118891U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) F32GM134560U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) K99GM143550
Abstract
Post-translational modifications (PTMs) on histones are a key source of regulation on chromatin through impacting cellular processes, including gene expression
Indexed as
Gastrointestinal MicrobiomeGene Expression RegulationHistonesProtein Processing, Post-TranslationalAcetylationAnimalsFemaleIntestinal MucosaIntestinesMiceMice, Inbred C57BLTriglyceridesHistonestributyrinTriglycerides
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.