Evidence map›Paper›PMID 38413804›Full record

ArticleNature metabolism2024

PMF-seq: a highly scalable screening strategy for linking genetics to mitochondrial bioenergetics.

Tsz-Leung To, Jason G McCoy, Naomi K Ostriker, Lev S Sandler, Carmen A Mannella, Vamsi K Mootha

Open access · hybridAbstract read
In one paragraph

Article in Nature metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Guidelines for mitochondrial RNA analysis.Molecular therapy. Nucleic acids · 2024
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Tsz-Leung ToHoward Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0104-7607
Jason G McCoyHoward Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Naomi K OstrikerHoward Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2038-6866
Lev S SandlerHoward Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Carmen A MannellaDepartment of Physiology, Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD, USA.
Vamsi K MoothaHoward Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA. vamsi@hms.harvard.edu.ORCID http://orcid.org/0000-0001-9924-642X
Broad Institute · USUniversity of Maryland, Baltimore · US

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
Transgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI FLOREZ, JOSE CARLOS · 2000 to 2019
$31.4M
P&F programP30DK135043 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Deborah J Wexler · 2023 to 2026
$5.4M
Structure, function, and disease biology of MICU1/MICU2R01AR071942 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI Zenon Grabarek, Vamsi Krishna Mootha · 2018 to 2026
$4.1M
Mitochondrial Parts, Pathways, and PathogenesisR35GM122455 · NIGMS · BROAD INSTITUTE, INC. · PI MOOTHA, VAMSI KRISHNA · 2017 to 2021
$4.0M
NIAMS NIH HHS R01 AR071942NIDDK NIH HHS P30 DK043351NIDDK NIH HHS P30 DK057521NIDDK NIH HHS P30 DK135043NIGMS NIH HHS R35 GM122455
6 · The paper itself

Abstract

Our current understanding of mitochondrial organelle physiology has benefited from two broad approaches: classically, cuvette-based measurements with suspensions of isolated mitochondria, in which bioenergetic parameters are monitored acutely in response to respiratory chain substrates and inhibitors

Indexed as

Energy MetabolismMitochondriaHigh-Throughput Nucleotide SequencingHumans

Identifiers

PMID38413804
PMCPMC11052718
OpenAlexW4392193045

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.