ArticleNature communications2024
Comparative connectomics of dauer reveals developmental plasticity.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Comparative connectomics reveals stage-specific gap junction rewiring that reshapes avoidance behavior.bioRxiv : the preprint server for biology · 2026Article
- Optimization of connectome weights for a neural network model generating both forward and backward locomotion in C. elegans.Scientific reports · 2026Article
- Physical contact reveals a hidden layer of cortical architecture.bioRxiv : the preprint server for biology · 2026Article
- Article
- A three-dimensional immunofluorescence atlas of the brain of the hackled-orb weaver spider,eLife · 2026Article
- Nictation behavior in nematodes.BMC biology · 2025Review
- Exploring neurodevelopment via spatiotemporal collation of anatomical networks with NeuroSC.eLife · 2025Article
- Identity and functions of monoaminergic neurons in the predatory nematodebioRxiv : the preprint server for biology · 2025Article
- A multilayered gap junction network is essential for social decision-making.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Structural Diversity of Mitochondria in the Neuromuscular System across Development Revealed by 3D Electron Microscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Sources of behavioral variability in C. elegans: Sex differences, individuality, and internal states.Current opinion in neurobiology · 2025Review
- Nervous system-wide analysis of allScience advances · 2025Article
- Review
- The many roads toJournal of biosciences · 2025Review
- Robustness and variability inbioRxiv : the preprint server for biology · 2024Article
- Glial expression of a steroidogenic enzyme underlies natural variation in hitchhiking behavior.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Distinct neurogenetic mechanisms establish the same chemosensory valence state at different life stages in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2024Article
- Article
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12 authors.
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Abstract
A fundamental question in neurodevelopmental biology is how flexibly the nervous system changes during development. To address this, we reconstructed the chemical connectome of dauer, an alternative developmental stage of nematodes with distinct behavioral characteristics, by volumetric reconstruction and automated synapse detection using deep learning. With the basic architecture of the nervous system preserved, structural changes in neurons, large or small, were closely associated with connectivity changes, which in turn evoked dauer-specific behaviors such as nictation. Graph theoretical analyses revealed significant dauer-specific rewiring of sensory neuron connectivity and increased clustering within motor neurons in the dauer connectome. We suggest that the nervous system in the nematode has evolved to respond to harsh environments by developing a quantitatively and qualitatively differentiated connectome.
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