Evidence map›Paper›PMID 38413593›Full record

ArticleNPJ vaccines2024

MVA-based vaccines are protective against lethal eastern equine encephalitis virus aerosol challenge in cynomolgus macaques.

Brandon J Beddingfield, Kenneth S Plante, Jessica A Plante, Scott C Weaver, Sarah Bose, Clara Krzykwa, Nicole Chirichella, Rachel K Redmann, Stephanie Z Seiler, Jason Dufour and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Eastern Equine Encephalitis Virus: The Importance of Metabolism and Aging.International journal of molecular sciences · 2024
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Brandon J BeddingfieldDivision of Microbiology, Tulane National Primate Research Center, Covington, LA, USA.ORCID http://orcid.org/0000-0002-9438-1304
Kenneth S PlanteDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.ORCID http://orcid.org/0000-0002-7485-3167
Jessica A PlanteDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.ORCID http://orcid.org/0000-0002-4768-7458
Scott C WeaverDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.ORCID http://orcid.org/0000-0001-8016-8556
Sarah BoseDivision of Microbiology, Tulane National Primate Research Center, Covington, LA, USA.
Clara KrzykwaDivision of Microbiology, Tulane National Primate Research Center, Covington, LA, USA.
Nicole ChirichellaDivision of Microbiology, Tulane National Primate Research Center, Covington, LA, USA.
Rachel K RedmannDivision of Microbiology, Tulane National Primate Research Center, Covington, LA, USA.ORCID http://orcid.org/0000-0002-8822-0707
Stephanie Z SeilerDivision of Microbiology, Tulane National Primate Research Center, Covington, LA, USA.
Jason DufourDivision of Veterinary Medicine, Tulane National Primate Research Center, Covington, LA, USA.
Robert V BlairDivision of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, USA.
Kathrin EndtBavarian Nordic GmbH, Fraunhofer Strasse 13, 82152, Martinsried, Germany.
Ariane VolkmannBavarian Nordic GmbH, Fraunhofer Strasse 13, 82152, Martinsried, Germany.
Nicholas J ManessDivision of Microbiology, Tulane National Primate Research Center, Covington, LA, USA.
Chad J RoyDivision of Microbiology, Tulane National Primate Research Center, Covington, LA, USA. croy@tulane.edu.ORCID http://orcid.org/0000-0002-1710-6974
Tulane University · USThe University of Texas Medical Branch at Galveston · USBavarian Nordic (Germany) · DE

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
World Reference Center for Emerging Viruses and Arboviruses (WRCEVA)R24AI120942 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WEAVER, SCOTT C · 2016 to 2024
$8.5M
NIAID NIH HHS HHSN272201700011CNIAID NIH HHS R24 AI120942NIH HHS P51 OD011104
6 · The paper itself

Abstract

MVA-based monovalent eastern equine encephalitis virus (MVA-BN-EEEV) and multivalent western, eastern, and Venezuelan equine encephalitis virus (MVA-BN-WEV) vaccines were evaluated in the cynomolgus macaque aerosol model of EEEV infection. Macaques vaccinated with two doses of 5 × 10

Identifiers

PMID38413593
PMCPMC10899228
OpenAlexW4392198635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.