Evidence map›Paper›PMID 38413484›Full record

Observational studyEuropean journal of nutrition2024

Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study.

Leena Hakola, Lazarus K Mramba, Ulla Uusitalo, Carin Andrén Aronsson, Sandra Hummel, Sari Niinistö, Iris Erlund, Jimin Yang, Marian J Rewers, Beena Akolkar and 10 more

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. The role of GABA in type 1 diabetes.Frontiers in endocrinology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 14 institutions in 4 countries.

Leena HakolaFaculty of Social Sciences, Unit of Health Sciences, Tampere University, 33014, Tampere, Finland. leena.hakola@tuni.fi.ORCID http://orcid.org/0000-0001-7115-6035
Lazarus K MrambaHealth Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Ulla UusitaloHealth Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Carin Andrén AronssonDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Sandra HummelInstitute of Diabetes Research, Helmholtz Munich, German Research Center for Environmental Health, Munich, Germany.
Sari NiinistöHealth and Well-Being Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
Iris ErlundDepartment of Government Services, Finnish Institute for Health and Welfare, Helsinki, Finland.
Jimin YangHealth Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Marian J RewersDavis Center for Childhood Diabetes, University of Colorado, Aurora, CO, USA.
Beena AkolkarNational Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
Richard A McIndoeCenter for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
William A HagopianPacific Northwest Research Institute, Seattle, WA, USA.
Anette ZieglerInstitute of Diabetes Research, Helmholtz Munich, German Research Center for Environmental Health, Munich, Germany.
Åke LernmarkDepartment of Clinical Sciences, Lund University CRC, Skåne University Hospital, Malmö, Sweden.
Jorma ToppariDepartment of Pediatrics, Turku University Hospital, Turku, Finland.
Jeffrey P KrischerHealth Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Jill M NorrisDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Suvi M VirtanenFaculty of Social Sciences, Unit of Health Sciences, Tampere University, 33014, Tampere, Finland.
TEDDY Study Group
University of South Florida · USPacific Northwest Diabetes Research Institute · USTUM Klinikum · DEUniversity of Colorado Anschutz Medical Campus · USColorado School of Public Health · USTampere University · FITampere University Hospital · FIAugusta University · USFinnish Institute for Health and Welfare · FILund University · SEUniversity of Turku · FINational Institute of Diabetes and Digestive and Kidney Diseases · USSkåne University Hospital · SEUniversity of Virginia · US

Funding

Limited Competition: Continued Follow-up of Subjects and Initiation of a Second Case-control Cohort in The Environmental Determinants of Diabetes in The Young Study (TEDDY)U01DK128847 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI JEFFREY P KRISCHER · 2021 to 2026
$79.2M
NIDDK NIH HHS U01 DK128847
6 · The paper itself

Abstract

purposeThe aim was to study the association between dietary intake of B vitamins in childhood and the risk of islet autoimmunity (IA) and progression to type 1 diabetes (T1D) by the age of 10 years.

methodsWe followed 8500 T1D-susceptible children born in the U.S., Finland, Sweden, and Germany in 2004 -2010 from the Environmental Determinants of Diabetes in the Young (TEDDY) study, which is a prospective observational birth cohort. Dietary intake of seven B vitamins was calculated from foods and dietary supplements based on 24-h recall at 3 months and 3-day food records collected regularly from 6 months to 10 years of age. Cox proportional hazard models were adjusted for energy, HLA-genotype, first-degree relative with T1D, sex, and country.

resultsA total of 778 (9.2) children developed at least one autoantibody (any IA), and 335 (3.9%) developed multiple autoantibodies. 280 (3.3%) children had IAA and 319 (3.8%) GADA as the first autoantibody. 344 (44%) children with IA progressed to T1D. We observed that higher intake of niacin was associated with a decreased risk of developing multiple autoantibodies (HR 0.95; 95% CI 0.92, 0.98) per 1 mg/1000 kcal in niacin intake. Higher intake of pyridoxine (HR 0.66; 95% CI 0.46, 0.96) and vitamin B12 (HR 0.87; 95% CI 0.77, 0.97) was associated with a decreased risk of IAA-first autoimmunity. Higher intake of riboflavin (HR 1.38; 95% CI 1.05, 1.80) was associated with an increased risk of GADA-first autoimmunity. There were no associations between any of the B vitamins and the outcomes "any IA" and progression from IA to T1D. 

conclusionIn this multinational, prospective birth cohort of children with genetic susceptibility to T1D, we observed some direct and inverse associations between different B vitamins and risk of IA.

Indexed as

AutoantibodiesAutoimmunityDiabetes Mellitus, Type 1Islets of LangerhansVitamin B ComplexBirth CohortChildChild, PreschoolDietDietary SupplementsDisease ProgressionFemaleFinlandGermanyHumansInfantAutoantibodiesVitamin B ComplexBirth cohortDiabetes mellitus, type 1Nutrient intakeVitamin B complex

Identifiers

PMID38413484
PMCPMC11139689
OpenAlexW4392189568

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.