Evidence map›Paper›PMID 38413481›Full record

ArticleDrugs in R&D2024

Case Report: Life-Threatening Fluoxetine-Linked Postoperative Bleeding Informed by Pharmacogenetic Evaluation.

Sara Rogers, Patrick J Silva, George Udeani, Monica Deleon, Sriarchala Mutyala, Ladan Panahi, Asim Abu-Baker, Gabriel Neal, Kenneth S Ramos

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Drugs in R&D, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Sara RogersDepartment of Pharmacy Practice, Irma Lerma Rangel School of Pharmacy, Texas A&M University, Kingsville, TX, 78363, USA. sararogers@tamu.edu.ORCID http://orcid.org/0000-0002-9851-4151
Patrick J SilvaDepartment of Translational Medical Sciences, School of Medicine, Texas A&M Health Science Center, Bryan, TX, 77807, USA.ORCID http://orcid.org/0000-0002-8870-6440
George UdeaniDepartment of Pharmacy Practice, Irma Lerma Rangel School of Pharmacy, Texas A&M University, Kingsville, TX, 78363, USA.ORCID http://orcid.org/0000-0001-5797-7849
Monica DeleonDepartment of Pharmacy Practice, Irma Lerma Rangel School of Pharmacy, Texas A&M University, Kingsville, TX, 78363, USA.
Sriarchala MutyalaDepartment of Pharmacy Practice, Irma Lerma Rangel School of Pharmacy, Texas A&M University, Kingsville, TX, 78363, USA.
Ladan PanahiDepartment of Pharmacy Practice, Irma Lerma Rangel School of Pharmacy, Texas A&M University, Kingsville, TX, 78363, USA.ORCID http://orcid.org/0000-0002-0286-3788
Asim Abu-BakerDepartment of Pharmacy Practice, Irma Lerma Rangel School of Pharmacy, Texas A&M University, Kingsville, TX, 78363, USA.ORCID http://orcid.org/0000-0002-2040-1878
Gabriel NealDepartment of Primary Care and Rural Medicine, School of Medicine, Texas A&M Health Science Center, Bryan, TX, 77807, USA.ORCID http://orcid.org/0000-0002-9441-6589
Kenneth S RamosDepartment of Translational Medical Sciences, School of Medicine, Texas A&M Health Science Center, Bryan, TX, 77807, USA.ORCID http://orcid.org/0000-0002-0692-4066
Texas A&M Health Science Center · USTexas A&M University – Kingsville · USTexas A&M University – San Antonio · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSelective serotonin reuptake inhibitors (SSRI) are commonly used for the treatment of depression and anxiety. Inhibition of serotonin reuptake in platelets increases bleeding risk in patients taking SSRIs. CASE: Here, we present the case of a 52-year-old patient who developed severe postsurgical bleeding requiring blood transfusion following panniculectomy.

conclusionSSRI-induced bleeding is dose-related and strongly influenced by individual variations in drug metabolizing enzymes and transporters. Supplementary file1 (MP4 8441 KB).

Indexed as

FluoxetinePostoperative HemorrhageSelective Serotonin Reuptake InhibitorsHumansMiddle AgedPharmacogeneticsFluoxetineSelective Serotonin Reuptake Inhibitors

Identifiers

PMID38413481
PMCPMC11035520
OpenAlexW4392235623

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.