Evidence map›Paper›PMID 38413098›Full record

ArticleBMJ global health2024

Malaria trends in districts that were targeted and not-targeted for seasonal malaria chemoprevention in children under 5 years of age in Guinea, 2014-2021.

Donal Bisanzio, Mamadou Sitan Keita, Alioune Camara, Timothée Guilavogui, Thierno Diallo, Hamidou Barry, Adam Preston, Lamine Bangoura, Eliane Mbounga, Lia S Florey and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ global health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 5 countries.

Donal BisanzioRTI International, Washington, District of Columbia, USA.
Mamadou Sitan KeitaRTI International, Conakry, Guinea.
Alioune CamaraProgramme National de la Lutte contre le Paludisme, Ministère de la Santé et de l'Hygiène Publique, Conakry, Guinea.
Timothée GuilavoguiMinistère de la Santé et de l'Hygiène Publique, Conakry, Guinea.
Thierno DialloRTI International, Conakry, Guinea.
Hamidou BarryRTI International, Conakry, Guinea.
Adam PrestonRTI International, Fort Collins, Colorado, USA.
Lamine BangouraPresident's Malaria Initiative, US Agency for International Development, Conakry, Guinea.
Eliane MboungaPresident's Malaria Initiative, US Agency for International Development, Conakry, Guinea.
Lia S FloreyUS Agency for International Development, Washington, District of Columbia, USA.
Jean-Luc TatonRTI International, Conakry, Guinea.
Aissata FofanaRTI International, Conakry, Guinea.
Richard ReithingerRTI International, Washington, District of Columbia, USA rreithinger@yahoo.co.uk.ORCID 0000-0001-5710-1556
RTI International · USU.S. President's Malaria Initiative · USEngineering Data Management · USMinistère de la Santé et de l'Hygiène Publique · MLMinistry of Health and Public Hygiene · GNUnited States Agency for International Development · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeasonal malaria chemoprevention (SMC) is a main intervention to prevent and reduce childhood malaria. Since 2015, Guinea has implemented SMC targeting children aged 3-59 months (CU5) in districts with high and seasonal malaria transmission.

objectiveWe assessed the programmatic impact of SMC in Guinea's context of scaled up malaria intervention programming by comparing malaria-related outcomes in 14 districts that had or had not been targeted for SMC.

methodsUsing routine health management information system data, we compared the district-level monthly test positivity rate (TPR) and monthly uncomplicated and severe malaria incidence for the whole population and disaggregated age groups (<5 years and ≥5 years of age). Changes in malaria indicators through time were analysed by calculating the district-level compound annual growth rate (CAGR) from 2014 to 2021; we used statistical analyses to describe trends in tested clinical cases, TPR, uncomplicated malaria incidence and severe malaria incidence.

resultsThe CAGR of TPR of all age groups was statistically lower in SMC (median=-7.8%) compared with non-SMC (median=-3.0%) districts. Similarly, the CAGR in uncomplicated malaria incidence was significantly lower in SMC (median=1.8%) compared with non-SMC (median=11.5%) districts. For both TPR and uncomplicated malaria incidence, the observed difference was also significant when age disaggregated. The CAGR of severe malaria incidence showed that all age groups experienced a decline in severe malaria in both SMC and non-SMC districts. However, this decline was significantly higher in SMC (median=-22.3%) than in non-SMC (median=-5.1%) districts for the entire population, as well as both CU5 and people over 5 years of age.

conclusionEven in an operational programming context, adding SMC to the malaria intervention package yields a positive epidemiological impact and results in a greater reduction in TPR, as well as the incidence of uncomplicated and severe malaria in CU5.

Indexed as

AntimalarialsMalariaChemopreventionChildChild, PreschoolGuineaHumansSeasonsAntimalarialsControl strategiesMalariaPrevention strategiesPublic Health

Identifiers

PMID38413098
PMCPMC10900330
OpenAlexW4392202461

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.