Evidence map›Paper›PMID 38413095›Full record

ArticleFEBS letters2024

Resveratrol and its metabolites elicit neuroprotection via high-affinity binding to the laminin receptor at low nanomolar concentrations.

Rayudu Gopalakrishna, Jennifer Aguilar, Andrew Oh, Emily Lee, Lucas Hou, Tammy Lee, Eric Xu, James Nguyen, William J Mack

Open access · hybridAbstract read
In one paragraph

Article in FEBS letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Rayudu GopalakrishnaDepartment of Integrative Anatomical Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-0398-3116
Jennifer AguilarDepartment of Integrative Anatomical Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Andrew OhDepartment of Integrative Anatomical Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Emily LeeDepartment of Integrative Anatomical Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Lucas HouDepartment of Integrative Anatomical Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Tammy LeeDepartment of Integrative Anatomical Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Eric XuDepartment of Integrative Anatomical Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
James NguyenDepartment of Integrative Anatomical Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
William J MackDepartment of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
University of Southern California · US

Funding

Synergistic white matter injury from diesel exhaust particulate and chronic cerebral hypoperfusion exposures: Interaction between the Nogo/NgR1 receptor pathway and extravascular fibrinogen toxicityRF1NS130681 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GOPALAKRISHNA, RAYUDU, MACK, WILLIAM J · 2022 to 2025
$3.9M
Translational potential of the internalization of Nogo-A receptor to enhance axonal regeneration after strokeR21NS116720 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GOPALAKRISHNA, RAYUDU, MACK, WILLIAM J · 2020 to 2020
$454k
NIH HHS NINDS/NIA RF1 NS130681NIH HHS NINDS R21 NS116720NINDS NIH HHS R21 NS116720NINDS NIH HHS RF1 NS130681
6 · The paper itself

Abstract

Resveratrol prevents various neurodegenerative diseases in animal models despite reaching only low nanomolar concentrations in the brain after oral administration. In this study, based on the quenching of intrinsic tryptophan fluorescence and molecular docking, we found that trans-resveratrol, its conjugates (glucuronide and sulfate), and dihydro-resveratrol (intestinal microbial metabolite) bind with high affinities (K

Indexed as

Neuroprotective AgentsReceptors, LamininResveratrolAnimalsBinding SitesGlucuronidesHumansMolecular Docking SimulationNeuronsNeuroprotectionProtein BindingRibosomal ProteinsSignal TransductionStilbenesGlucuronidesNeuroprotective AgentsReceptors, LamininResveratrolRibosomal ProteinsRPSA protein, humanStilbenes67‐kDa laminin receptorcAMPepigallocatechin‐3‐gallateglycosaminoglycanneuroprotectionresveratrol‐3‐glucuronide

Identifiers

PMID38413095
PMCPMC11087200
OpenAlexW4392195564

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.