ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2024
Association of brain functional connectivity with neurodevelopmental outcomes in healthy full-term newborns.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.
- EEG signatures of motor development in early childhood: a systematic review.Pediatric research · 2026Pooled it
- Prenatal parental mental health and neurodevelopment in children with congenital heart disease.Pediatric research · 2026Review
- Directional flow of brain connections and neurodevelopmental outcomes in healthy full-term newborns.Neuroscience letters · 2025Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo study the association between neurodevelopmental outcomes and functional brain connectivity (FBC) in healthy term infants.
methodsThis is a retrospective study of prospectively collected High-density electroencephalography (HD-EEG) from newborns within 72 hours from birth. Developmental assessments were performed at two years of age using the Bayley Scales of Infant Development-III (BSID-III) measuring cognitive, language, motor, and socio-emotional scores. The FBC was calculated using phase synchronization analysis of source signals in delta, theta, alpha, beta, and gamma frequency bands and its association with neurodevelopmental score was assessed with stepwise regression.
results47/163 had both HD-EEG and BSID-III scores. The FBC of frontal region was associated with cognitive score in the theta band (corrected p, regression coefficients range: p < 0.01, 1.66-1.735). Language scores were significantly associated with connectivity in all frequency bands, predominantly in the left hemisphere (p < 0.01, -2.74-2.40). The FBC of frontal and occipital brain regions of both hemispheres was related to motor score and socio-emotional development in theta, alpha, and gamma frequency bands (p < 0.01, -2.16-2.97).
conclusionsFunctional connectivity of higher-order processing is already present at term age. SIGNIFICANCE: The FBC might be used to guide interventions for optimizing subsequent neurodevelopment even in low-risk newborns.
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Registered trials
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