Evidence map›Paper›PMID 38412252›Full record

ArticleACS nano2024

Iron Oxide Nanoparticles Engineered Macrophage-Derived Exosomes for Targeted Pathological Angiogenesis Therapy.

Haorui Zhang, Yu Mao, Zheng Nie, Qing Li, Mengzhu Wang, Chang Cai, Weiju Hao, Xi Shen, Ning Gu, Wei Shen and 1 more

Open access · hybridAbstract read
In one paragraph

Article in ACS nano, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Haorui ZhangDepartment of Ophthalmology, Shanghai Changhai Hospital, Shanghai 200433, P.R. China.
Yu MaoNanjing Key Laboratory for Cardiovascular Information and Health Engineering Medicine, Institute of Clinical Medicine, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210093, P.R. China.
Zheng NieDepartment of Ophthalmology, Shanghai Changhai Hospital, Shanghai 200433, P.R. China.
Qing LiDepartment of Ophthalmology, Shanghai Changhai Hospital, Shanghai 200433, P.R. China.
Mengzhu WangDepartment of Ophthalmology, Shanghai Changhai Hospital, Shanghai 200433, P.R. China.
Chang CaiDepartment of Ophthalmology, Shanghai Changhai Hospital, Shanghai 200433, P.R. China.
Weiju HaoUniversity of Shanghai for Science and Technology, Shanghai 200093, P.R. China.ORCID 0000-0002-4238-081X
Xi ShenDepartment of Ophthalmology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, P.R. China.
Ning GuNanjing Key Laboratory for Cardiovascular Information and Health Engineering Medicine, Institute of Clinical Medicine, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210093, P.R. China.ORCID 0000-0003-0047-337X
Wei ShenDepartment of Ophthalmology, Shanghai Changhai Hospital, Shanghai 200433, P.R. China.ORCID 0000-0001-5754-316X
Hongyuan SongDepartment of Ophthalmology, Shanghai Changhai Hospital, Shanghai 200433, P.R. China.ORCID 0000-0001-8187-2799
Second Military Medical University · CNNanjing Drum Tower Hospital · CNShanghai Jiao Tong University · CNUniversity of Shanghai for Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Engineering exosomes with nanomaterials usually leads to the damage of exosomal membrane and bioactive molecules. Here, pathological angiogenesis targeting exosomes with magnetic imaging, ferroptosis inducing, and immunotherapeutic properties is fabricated using a simple coincubation method with macrophages being the bioreactor. Extremely small iron oxide nanoparticle (ESIONPs) incorporated exosomes (ESIONPs@EXO) are acquired by sorting the secreted exosomes from M1-polarized macrophages induced by ESIONPs. ESIONPs@EXO suppress pathological angiogenesis

Indexed as

ExosomesAngiogenesisHumansMacrophagesMagnetic Iron Oxide NanoparticlesNeovascularization, Pathologicengineered exosomesferroptosisimmunotherapymacrophagepathological angiogenesisretinopathy

Identifiers

PMID38412252
PMCPMC10938920
OpenAlexW4392187866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.