ArticleCell reports2024
The genomic and evolutionary landscapes of anaplastic thyroid carcinoma.
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Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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54citing papers in PubMed
22.2field-weighted citation impact, top 1% of its field
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Who cites it
54 citing papers in PubMed, 63 citations in OpenAlex.
- EIF1AX Mutations in thyroid nodules and advanced thyroid carcinoma: a systematic review and meta-analysis.Virchows Archiv : an international journal of pathology · 2026Review
- RAC1 signaling in polyploid giant cancer cells: Implications for tumorigenesis and therapy resistance.Cancer letters · 2026Review
- Latin American Thyroid Society expert panel consensus on anaplastic thyroid cancer.Archives of endocrinology and metabolism · 2026Article
- Anaplastic thyroid cancer: genomic landscape, molecular drivers and novel therapeutics.Nature reviews. Endocrinology · 2026Review
- Spatial and single-nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers.Molecular oncology · 2026Article
- Single-cell RNA sequencing: a powerful tool to study heterogeneity in papillary and anaplastic thyroid carcinoma.European thyroid journal · 2026Review
- Thyroid cancer and double-strand DNA break repair: The potential role of the MRN complex pathogenic variants.Journal of clinical & translational endocrinology · 2026Review
- Evolving Pathology of Anaplastic Thyroid Carcinoma: Integrating Morphology, Immunohistochemistry, and Molecular Insights.Cancer science · 2026Review
- PRECISE: A Prognostic Thyrocyte-Derived Gene Signature for Papillary Thyroid Carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Article
- Targeting the Warburg Effect in Anaplastic Thyroid Carcinoma: Metabolic Vulnerabilities and Therapeutic Opportunities.International journal of molecular sciences · 2026Review
- Understanding and overcoming innate and acquired MAPK inhibition resistance in anaplastic thyroid cancer.Cell reports. Medicine · 2026Article
- Loss of CSE couples with BRAF V600E to fuel thyroid cancer metastatic progression through zinc-dependent activation of the EMT machinery.Journal of experimental & clinical cancer research : CR · 2026Article
- Real-world outcomes and prognostic factors in anaplastic thyroid cancer: evidence from the REGETNE-Thyroid cohort.The oncologist · 2026Article
- Current Studies on the Hypoxic Tumor Microenvironment in Thyroid Cancer: From Molecular Mechanisms to Clinical Therapeutic Perspectives.Biomedicines · 2026Review
- Role of the ETV5/p38 Signaling Axis in Aggressive Thyroid Cancer Cells.Molecular cancer therapeutics · 2026Article
- Chromophobe thyroid carcinoma: a distinct entity associated with TSC gene alterations.Virchows Archiv : an international journal of pathology · 2026Review
- Visualizing malignant progression: in situ CD109-based spatial immunofluorescence assay delineates papillary to anaplastic thyroid carcinoma transformation within the tumor microenvironment.Scientific reports · 2026Article
- Cancer Stemness and Dedifferentiation in Anaplastic Thyroid Carcinoma: Insights into a Multigenic, Microenvironmental Network and the Role of CD44.Biomedicines · 2026Review
- Anaplastic Thyroid Carcinoma and High-Grade Tall Cell Papillary Thyroid Carcinoma: Case Report of a Rare Association.Reports (MDPI) · 2026Article
- Whole-Exome Profiling of Epstein-Barr Virus-Positive Neuroendocrine Carcinoma of the Nasopharynx.Endocrine pathology · 2026Article
Corrections and comments
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Authors and funding
69 authors at 20 institutions in 4 countries.
Peter Y F ZengDepartment of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada; London Regional Cancer Program, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada.
Stephenie D ProkopecOntario Institute for Cancer Research, Toronto, ON, Canada; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.
Stephen Y LaiDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Nicole PintoDepartment of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada.
Michelle A Chan-Seng-YueOntario Institute for Cancer Research, Toronto, ON, Canada.
Roderick Clifton-BlighDivision of Endocrinology, Royal North Shore Hospital, and University of Sydney, Sydney, NSW, Australia.
Michelle D WilliamsDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Christopher J HowlettDepartment of Pathology, Western University, London, ON, Canada.
Paul PlantingaDepartment of Pathology, Western University, London, ON, Canada.
Matthew J CecchiniDepartment of Pathology, School of Medicine, Griffith University, Gold Coast, QLD, Australia.
Alfred K LamDepartment of Pathology, School of Medicine, Griffith University, Gold Coast, QLD, Australia.
Iram SiddiquiDepartment of Laboratory Medicine, Hospital for Sick Children, Toronto, ON, Canada.
Jianxin WangOntario Institute for Cancer Research, Toronto, ON, Canada.
Ren X SunOntario Institute for Cancer Research, Toronto, ON, Canada.
John D WatsonOntario Institute for Cancer Research, Toronto, ON, Canada; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.
Reju KorahDepartment of Surgery, Yale University, New Haven, CT, USA.
Tobias CarlingDepartment of Surgery, Yale University, New Haven, CT, USA.
Nishant AgrawalDepartment of Otolaryngology - Head and Neck Surgery, University of Chicago, Chicago, IL, USA.
Nicole CiprianiDepartment of Pathology, University of Chicago, Chicago, IL, USA.
Douglas BallDivision of Endocrinology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Barry NelkinSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA.
Lisa M RooperDivision of Pathology, Johns Hopkins University, Baltimore, MD, USA.
Justin A BishopDepartment of Pathology, University of Texas Southwestern, Dallas, TX, USA.
Cathie GarnisBC Cancer Agency, Vancouver, BC, Canada.
Ken BereanBC Cancer Agency, Vancouver, BC, Canada.
Norman G NicolsonDepartment of Surgery, Yale University, New Haven, CT, USA.
Paul WeinbergerDepartment of Otolaryngology - Head and Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, USA; Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Ying C HendersonDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Christopher M LalansinghOntario Institute for Cancer Research, Toronto, ON, Canada.
Mao TianInstitute for Precision Health, University of California, Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.
Takafumi N YamaguchiOntario Institute for Cancer Research, Toronto, ON, Canada; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.
Julie LivingstoneOntario Institute for Cancer Research, Toronto, ON, Canada; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.
Adriana SalcedoOntario Institute for Cancer Research, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Krupal PatelDepartment of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada; Ontario Institute for Cancer Research, Toronto, ON, Canada.
Frederick VizeacoumarCancer Research Cluster, University of Saskatchewan, Saskatoon, SK, Canada.
Alessandro DattiNetwork Biology Collaborative Centre, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada; Department of Agricultural, Food, and Environmental Sciences, University of Perugia, Perugia, Italy.
Liu XiDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Yuri E NikiforovDepartment of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Robert SmallridgeDivision of Endocrinology, Department of Medicine, Mayo Clinic, Jacksonville, FL, USA.
John A CoplandDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.
Laura A MarlowDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.
Martin D HyrczaDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
Leigh DelbridgeDepartment of Surgery, Royal North Shore Hospital, Sydney, NSW, Australia; University of Sydney, Sydney, NWS, Australia.
Stan SidhuDepartment of Surgery, Royal North Shore Hospital, Sydney, NSW, Australia; University of Sydney, Sydney, NWS, Australia.
Mark SywakDepartment of Surgery, Royal North Shore Hospital, Sydney, NSW, Australia; University of Sydney, Sydney, NWS, Australia.
Bruce RobinsonUniversity of Sydney, Sydney, NWS, Australia; Department of Endocrinology, Royal North Shore Hospital, Sydney, NSW, Australia.
Kevin FungDepartment of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada.
Farhad GhasemiDepartment of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada.
Keith KwanDepartment of Pathology, Western University, London, ON, Canada.
S Danielle MacNeilDepartment of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada.
Adrian MendezDepartment of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada.
David A PalmaLondon Regional Cancer Program, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada.
Mohammed I KhanDepartment of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada.
Mushfiq ShaikhDepartment of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada.
Kara M RuicciDepartment of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada.
Bret WehrliDepartment of Pathology, Western University, London, ON, Canada.
Eric WinquistLondon Regional Cancer Program, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada.
John YooDepartment of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada.
Joe S MymrykDepartment of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada; London Regional Cancer Program, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada; Department of Microbiology and Immunology, Western University, London, ON, Canada.
James W RoccoDepartment of Otolaryngology - Head and Neck Surgery, Ohio State University, Columbus, OH, USA.
David WheelerDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Steve SchererDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Thomas J GiordanoDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
John W BarrettDepartment of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada.
William C FaquinDepartment of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Anthony J GillUniversity of Sydney, Sydney, NWS, Australia; Cancer Diagnosis and Pathology Group, Kolling Institute of Medicine, Royal North Shore Hospital, Sydney, NSW, Australia; NSW Health Pathology, Department of Anatomical Pathology, Royal North Shore Hospital, Sydney, NSW, Australia.
Gary ClaymanThe Clayman Thyroid Surgery and Thyroid Cancer Center, The Thyroid Institute, Tampa General Hospital, Tampa, FL, USA.
Paul C BoutrosDepartment of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA; Department of Urology, University of California, Los Angeles, Los Angeles, CA, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA, USA; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: pboutros@mednet.ucla.edu.
Anthony C NicholsDepartment of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada; London Regional Cancer Program, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada. Electronic address: anthony.nichols@lhsc.on.ca.
Western University · CAOntario Institute for Cancer Research · CAThe University of Sydney · AUBaylor College of Medicine · USJohns Hopkins University · USThe University of Texas MD Anderson Cancer Center · USYale University · USBC Cancer Agency · CAGriffith University · AUMayo Clinic in Florida · USUniversity of California, Los Angeles · USUniversity of Chicago · USHarvard University · USHospital for Sick Children · CALouisiana State University Health Sciences Center Shreveport · USMcMaster University · CAMount Sinai Hospital · CATampa General Hospital · USThe Ohio State University · USThe University of Texas Southwestern Medical Center · US
Funding
Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert Damoiseaux · 1985 to 2026
$134.5MAdvancing method benchmarking and data sharing through crowd-sourced competitions in cancer researchU24CA248265 · NCI · SAGE BIONETWORKS · PI BOUTROS, PAUL CHRISTOPHER, VARMA, SUSHEEL · 2020 to 2024
$4.1MRhoB in cancer pathogenesis and as a target in combinatorial therapyR01CA136665 · NCI · MAYO CLINIC JACKSONVILLE · PI COPLAND, JOHN A., SMALLRIDGE, ROBERT · 2010 to 2014
$1.6MNCI NIH HHS P30 CA016042NCI NIH HHS R01 CA136665NCI NIH HHS U24 CA248265
Abstract
Anaplastic thyroid carcinoma is arguably the most lethal human malignancy. It often co-occurs with differentiated thyroid cancers, yet the molecular origins of its aggressivity are unknown. We sequenced tumor DNA from 329 regions of thyroid cancer, including 213 from patients with primary anaplastic thyroid carcinomas. We also whole genome sequenced 9 patients using multi-region sequencing of both differentiated and anaplastic thyroid cancer components. Using these data, we demonstrate thatanaplastic thyroid carcinomas have a higher burden of mutations than other thyroid cancers, with distinct mutational signatures and molecular subtypes. Further, different cancer driver genes are mutated in anaplastic and differentiated thyroid carcinomas, even those arising in a single patient. Finally, we unambiguously demonstrate that anaplastic thyroid carcinomas share a genomic origin with co-occurring differentiated carcinomas and emerge from a common malignant field through acquisition of characteristic clonal driver mutations.
Indexed as
AdenocarcinomaThyroid Carcinoma, AnaplasticThyroid NeoplasmsGenomicsHumansMutationanaplastic thyroid cancercancer progressionCP: CancerCP: Genomicsgenomicstumour evolutiontumour heterogeneity
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