Evidence map›Paper›PMID 38412024›Full record

ArticleUnited European gastroenterology journal2024

Faecal incontinence with concurrent disorders of gut-brain interaction: A worse outcome.

Sarah G Li, Yoav Mazor, Calvin Joomann Park, Michael P Jones, Allison Malcolm

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in United European gastroenterology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Sarah G LiThe University of Sydney, Sydney, New South Wales, Australia.ORCID 0009-0008-5437-1970
Yoav MazorDepartment of Gastroenterology, Rambam Health Care Campus, Haifa, Israel.ORCID 0000-0001-8590-6271
Calvin Joomann ParkThe University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-4168-2971
Michael P JonesDepartment of Psychology, Macquarie University, Sydney, New South Wales, Australia.ORCID 0000-0003-0565-4938
Allison MalcolmThe University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0001-9795-3788
The University of Sydney · AUHebrew University of Jerusalem · ILMacquarie University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFaecal incontinence is a common debilitating condition associated with poor quality of life that generates substantial economic strain on healthcare systems.

objectivesWe aimed to evaluate, in a tertiary referral population presenting with faecal incontinence, the impact of suffering additional disorders of gut-brain interaction (DGBI) on symptom severity, anxiety, depression and quality of life.

methodsDesign: Retrospective cohort study.

settingTertiary referral Neurogastroenterology centre. PATIENTS: All patients presenting with faecal incontinence from 2007 to 2020 were included.

main outcome measuresThe results from structured medical and surgical questionnaires including Rome III Integrative Questionnaire, Faecal Incontinence Severity Index, Hospital Anxiety and Depression Scale, SF-36, and anorectal physiology were analysed using Stata version 17. Patients were categorised into 3 groups: 0-1 additional DGBI, 2 DGBIs, and 3+ DGBI. Statistical significance was defined as p < 0.05 (two-tailed). KEY

resultsFaecal incontinence patients (n = 249; mean age 63.4 ± 12.6 years; 93.6% female, 48.1% urge subtype) met diagnostic criteria for mean 2.2 additional DGBI each, mostly affecting bowel (n = 231, 42.4%) and anorectal (n = 150, 27.5%) regions. A greater number of DGBIs was associated with higher faecal incontinence symptom severity (p < 0.001), higher anxiety (p = 0.002) and depression (p = 0.003), and worse quality of life in areas of mental health (p = 0.037) and social effect (p < 0.001). Patients with a greater number of concurrent DGBI demonstrated a greater family history of gastrointestinal problems (p = 0.004). There were no associations found between a greater amount of DGBIs and anorectal physiology. CONCLUSIONS AND INFERENCES: A greater number of additional DGBIs in faecal incontinence patients was associated with worse faecal incontinence symptoms, higher anxiety and depression scores, and worse quality of life but was unrelated to physiology. This highlights the need to proactively search for comorbid DGBI in patients presenting with faecal incontinence.

Indexed as

AnxietyBrain-Gut AxisDepressionFecal IncontinenceQuality of LifeSeverity of Illness IndexAgedFemaleHumansMaleMiddle AgedRetrospective StudiesSurveys and Questionnairesanxietybrain‐gut axisdepressiondisorders of gut‐brain interactionfunctional gastrointestinal disordersgastrointestinal diseasesmotilitypsychosocial functioningquality of life

Identifiers

PMID38412024
PMCPMC11091788
OpenAlexW4392184820

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.