Evidence map›Paper›PMID 38412000›Full record

ArticleAntimicrobial agents and chemotherapy2024

Amoebicidal effect of synthetic indoles against

Ines Sifaoui, Rubén L Rodríguez-Expósito, María Reyes-Batlle, Alejandra Dumpiérrez Ramos, Raquel Diana-Rivero, Fernando García-Tellado, David Tejedor, José E Piñero, Jacob Lorenzo-Morales

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.5field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ines SifaouiInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSPC), Universidad de La Laguna (ULL), La Laguna, Tenerife, Spain.ORCID 0000-0002-5649-8333
Rubén L Rodríguez-ExpósitoInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSPC), Universidad de La Laguna (ULL), La Laguna, Tenerife, Spain.
María Reyes-BatlleInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSPC), Universidad de La Laguna (ULL), La Laguna, Tenerife, Spain.
Alejandra Dumpiérrez RamosInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSPC), Universidad de La Laguna (ULL), La Laguna, Tenerife, Spain.
Raquel Diana-RiveroInstituto de Productos Naturales y Agrobiología, Consejo Superior de Investigaciones Científicas, La Laguna, Tenerife, Spain.
Fernando García-TelladoInstituto de Productos Naturales y Agrobiología, Consejo Superior de Investigaciones Científicas, La Laguna, Tenerife, Spain.
David TejedorInstituto de Productos Naturales y Agrobiología, Consejo Superior de Investigaciones Científicas, La Laguna, Tenerife, Spain.ORCID 0000-0003-3262-0776
José E PiñeroInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSPC), Universidad de La Laguna (ULL), La Laguna, Tenerife, Spain.ORCID 0000-0001-6233-8224
Jacob Lorenzo-MoralesInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSPC), Universidad de La Laguna (ULL), La Laguna, Tenerife, Spain.ORCID 0000-0002-7683-2888
Universidad de La Laguna · ESConsejo Superior de Investigaciones Científicas · ES

Funding

Agencia Canaria de Investigación, Innovación y Sociedad de la Información (ACIISI) TESIS2020010117Centro de Investigación Biomédica en Red (CIBER) CB21/13/00100PID2022-136566NB-I00 and PDC2022-133706-I00 funded by MCIN/AEI/10.13039/501100011033 and by the EuropeanUnion NextGenerationEU/PRTR
6 · The paper itself

Abstract

Organic and synthetic chemistry plays a crucial role in drug discovery fields. Moreover, chemical modifications of available molecules to enhance their efficacy, selectivity and safety have been considered as an attractive approach for the development of new bioactive agents. Indoles, a versatile group of natural heterocyclic compounds, have been widely used in pharmaceutical industry due to their broad spectrum of activities including antimicrobial, antitumoral and anti-inflammatory among others. Herein, we report the amoebicidal activity of different indole analogs on

Indexed as

Acanthamoeba castellaniiAmebicidesApoptosisCell DeathIndolesAmebicidesIndolesAcanthamoeba spp.fluorescence microscopyindole derivativeprogram cell death

Identifiers

PMID38412000
PMCPMC10989003
OpenAlexW4392184744

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.