Evidence map›Paper›PMID 38411920›Full record

ArticleJournal of gastroenterology2024

Clinicopathological features and prognosis of primary small bowel adenocarcinoma: a large multicenter analysis of the JSCCR database in Japan.

Ken Yamashita, Shiro Oka, Takeshi Yamada, Keigo Mitsui, Hironori Yamamoto, Keiichi Takahashi, Akio Shiomi, Kinichi Hotta, Yoji Takeuchi, Toshio Kuwai and 46 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

56 authors at 20 institutions in 1 country.

Ken YamashitaDepartment of Gastroenterology, Hiroshima University Hospital, 1-2-3, Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
Shiro OkaDepartment of Gastroenterology, Hiroshima University Hospital, 1-2-3, Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan. oka4683@hiroshima-u.ac.jp.ORCID 0000-0002-1773-8293
Takeshi YamadaDepartment of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo, Japan.
Keigo MitsuiDepartment of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Tokyo, Japan.
Hironori YamamotoDepartment of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan.
Keiichi TakahashiDepartment of Colorectal Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
Akio ShiomiDivision of Colon and Rectal Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
Kinichi HottaDivision of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.
Yoji TakeuchiDepartment of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.
Toshio KuwaiDepartment of Gastroenterology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Hiroshima, Japan.
Fumio IshidaDigestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan.
Shin-Ei KudoDigestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan.
Shoichi SaitoDepartment of Lower Gastrointestinal Medicine, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.
Masashi UenoDepartment of Gastroenterological Surgery, Toranomon Hospital, Tokyo, Japan.
Eiji SunamiDepartment of Surgery, Kyorin University School of Medicine, Tokyo, Japan.
Tomoki YamanoDivision of Lower Gastrointestinal Surgery, Department of Surgery, Hyogo College of Medicine, Hyogo, Japan.
Michio ItabashiDepartment of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
Kazuo OhtsukaDepartment of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan.
Yusuke KinugasaDepartment of Gastrointestinal Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Takayuki MatsumotoDivision of Gastroenterology, Department of Internal Medicine, Iwate Medical University, Iwate, Japan.
Tamotsu SugaiDepartment of Diagnostic Pathology, Iwate Medical University, Iwate, Japan.
Toshio UraokaDepartment of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, Gunma, Japan.
Koichi KuraharaDivision of Gastroenterology, Matsuyama Red Cross Hospital, Ehime, Japan.
Shigeki YamaguchiDepartment of Gastroenterological Surgery, Saitama Medical University International Medical Center, Saitama, Japan.
Tomohiro KatoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Masazumi OkajimaDepartment of Surgery, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan.
Hiroshi KashidaDepartment of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan.
Yoshito AkagiDepartment of Surgery, Kurume University School of Medicine, Fukuoka, Japan.
Hiroaki IkematsuDepartment of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Chiba, Japan.
Masaaki ItoDepartment of Colorectal Surgery, National Cancer Center Hospital East, Chiba, Japan.
Motohiro EsakiDivision of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan.
Masaya KawaiDepartment of Coloproctological Surgery, Faculty of Medicine, Juntendo University, Tokyo, Japan.
Takashi YaoDepartment of Human Pathology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Madoka HamadaDepartment of Gastrointestinal Surgery, Kansai Medical University Hospital, Osaka, Japan.
Takahiro HorimatsuDepartment of Clinical Oncology, Kyoto University Hospital, Kyoto, Japan.
Keiji KodaDepartment of Surgery, Teikyo University Chiba Medical Center, Chiba, Japan.
Yasumori FukaiDepartment of Gastroenterology, Maebashi Red Cross Hospital, Gunma, Japan.
Koji KomoriDepartment of Gastroenterological Surgery, Aichi Cancer Center Hospital, Aichi, Japan.
Yusuke SaitohDepartment of Gastroenterology, Asahikawa City Hospital, Asahikawa, Hokkaido, Japan.
Yukihide KanemitsuDepartment of Colorectal Surgery, National Cancer Center Hospital, Tokyo, Japan.
Hiroyuki TakamaruEndoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
Kazutaka YamadaDepartment of Surgery, Coloproctology Center Takano Hospital, Kumamoto, Japan.
Hiroaki NozawaDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
Tetsuji TakayamaDepartment of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Kazutomo TogashiDepartment of Coloproctology, Aizu Medical Center, Fukushima Medical University, Fukushima, Japan.
Eiji ShintoDepartment of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan.
Takehiro TorisuDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Akira ToyoshimaDepartment of Colorectal Surgery, Japanese Red Cross Medical Center, Tokyo, Japan.
Naoki OhmiyaDepartment of Advanced Endoscopy, Fujita Health University School of Medicine, Aichi, Japan.
Takeshi KatoDepartment of Surgery, National Hospital Organization Osaka National Hospital, Osaka, Japan.
Eigo OtsujiDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Shinji NagataDepartment of Gastroenterology, Hiroshima City North Medical Center Asa Citizens Hospital, Hiroshima, Japan.
Yojiro HashiguchiDepartment of Surgery, Japanese Red Cross Omori Hospital, Tokyo, Japan.
Kenichi SugiharaTokyo Medical and Dental University, Tokyo, Japan.
Yoichi AjiokaDivision of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Shinji TanakaDepartment of Gastroenterology, Hiroshima University Hospital, 1-2-3, Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
Hiroshima University Hospital · JPNational Cancer Center Hospital East · JPTokyo Medical and Dental University · JPHiroshima City Asa Citizens Hospital · JPIwate Medical University · JPJikei University School of Medicine · JPJuntendo University · JPNippon Medical School · JPShizuoka Cancer Center · JPShowa University Northern Yokohama Hospital · JPAichi Cancer Center · JPAsahikawa City Hospital · JPFujita Health University · JPFukushima Medical University · JPGunma University · JPHyogo Medical University · JPJapanese Foundation For Cancer Research · JPJapanese Red Cross Medical Center · JPJichi Medical University · JPKansai Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe clinicopathological features and prognosis of primary small bowel adenocarcinoma (PSBA), excluding duodenal cancer, remain undetermined due to its rarity in Japan.

methodsWe analyzed 354 patients with 358 PSBAs, between January 2008 and December 2017, at 44 institutions affiliated with the Japanese Society for Cancer of the Colon and Rectum.

resultsThe median age was 67 years (218 males, 61.6%). The average tumor size was 49.9 (7-100) mm. PSBA sites consisted of jejunum (66.2%) and ileum (30.4%). A total of 219 patients (61.9%) underwent diagnostic small bowel endoscopy, including single-balloon endoscopy, double-balloon endoscopy, and capsule endoscopy before treatment. Nineteen patients (5.4%) had Lynch syndrome, and 272 patients (76.8%) had symptoms at the initial diagnosis. The rates for stages 0, I, II, III, and IV were 5.4%, 2.5%, 27.1%, 26.0%, and 35.6%, respectively. The 5-year overall survival rates at each stage were 92.3%, 60.0%, 75.9%, 61.4%, and 25.5%, respectively, and the 5-year disease-specific survival (DSS) rates were 100%, 75.0%, 84.1%, 59.3%, and 25.6%, respectively. Patients with the PSBA located in the jejunum, with symptoms at the initial diagnosis or advanced clinical stage had a worse prognosis. However, multivariate analysis using Cox-hazard model revealed that clinical stage was the only significant predictor of DSS for patients with PSBA.

conclusionsOf the patients with PSBA, 76.8% had symptoms at the initial diagnosis, which were often detected at an advanced stage. Detection during the early stages of PSBA is important to ensure a good prognosis.

Indexed as

AdenocarcinomaCapsule EndoscopyDuodenal NeoplasmsIleal NeoplasmsIntestinal NeoplasmsJejunal NeoplasmsAgedHumansJapanMalePrognosisCapsule endoscopyDouble-balloon endoscopyLynch syndromePrimary small bowel adenocarcinomaPrognosis

Identifiers

PMID38411920
PMCPMC11033235
OpenAlexW4392191208

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.