Evidence map›Paper›PMID 38411855›Full record

ArticleActa parasitologica2024

Exploring the Efficacy of Pellitorine as an Antiparasitic Agent Against Argulus: Impacts on Antioxidant Levels and Immune Responses in Goldfish (Carassius auratus).

Seenivasan Boopathi, D Kesavan, Gokul Sudhakaran, P Snega Priya, B Haridevamuthu, M Dhanaraj, S Seetharaman, Bader O Almutairi, Selvaraj Arokiyaraj, Ajay Guru and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Acta parasitologica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Seenivasan BoopathiToxicology and Pharmacology Laboratory, Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, Tamil Nadu, 603203, India.
D KesavanToxicology and Pharmacology Laboratory, Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, Tamil Nadu, 603203, India.
Gokul SudhakaranToxicology and Pharmacology Laboratory, Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, Tamil Nadu, 603203, India.
P Snega PriyaToxicology and Pharmacology Laboratory, Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, Tamil Nadu, 603203, India.
B HaridevamuthuToxicology and Pharmacology Laboratory, Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, Tamil Nadu, 603203, India.
M DhanarajFoundation for Aquaculture Innovations and Technology Transfer (FAITT), 4th Cross Street, Kumaran Kudil, Thoraipakkam, Chennai, Tamil Nadu, 600097, India.
S SeetharamanFoundation for Aquaculture Innovations and Technology Transfer (FAITT), 4th Cross Street, Kumaran Kudil, Thoraipakkam, Chennai, Tamil Nadu, 600097, India.
Bader O AlmutairiDepartment of Zoology, College of Science, King Saud University, P.O. Box 2455, 11451, Riyadh, Saudi Arabia.
Selvaraj ArokiyarajDepartment of Food Science and Biotechnology, Sejong University, Seoul, 05006, Korea.
Ajay GuruDepartment of Cariology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, 600 077, India. ajayguru.sdc@saveetha.com.
Jesu ArockiarajToxicology and Pharmacology Laboratory, Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, Tamil Nadu, 603203, India. jesuaroa@srmist.edu.in.
SRM Institute of Science and Technology · INKing Saud University · SASaveetha University · INSejong University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionArgulus spp. infestation is a significant challenge for aquaculture, currently, there are no approved medications available to efficiently manage this parasite. Consequently, mechanical removal of parasites using forceps and natural substances like herbs are being explored as alternative treatment methods. Pellitorine (PLE) is a naturally occurring compound found in several plant species. It is classified as an alkaloid and belongs to the class of compounds known as amides. MATERIALS AND

methodsThis study aimed to evaluate the effectiveness of PLE in preventing Argulus spp. infestations in goldfish (Carassius auratus) and to determine the optimal dosage of PLE for the detachment of Argulus spp.

resultsThe findings of this study revealed that PLE enhanced the immune response of goldfish by promoting superoxide dismutase (SOD) and catalase (CAT) in Argulus-infected goldfish. Additionally, PLE induces reactive oxygen species (ROS) generation and cellular damage in the Argulus. PLE at a dosage of 5 mg/mL was able to detach 80% of the argulus from goldfish within 12 h. Therapeutic index was found to be 5.99, suggesting that PLE is the safest drug.

conclusionsTherefore, our findings suggest that PLE can be a suitable and effective treatment option for preventing Argulus infestations in goldfish. The results of this study can guide the use of PLE at an optimal dosage to control Argulus infestation in goldfish.

Indexed as

AntioxidantsAntiparasitic AgentsArguloidaFatty Acids, UnsaturatedFish DiseasesGoldfishAnimalsCatalasePolyunsaturated AlkamidesReactive Oxygen SpeciesSuperoxide DismutaseAntioxidantsAntiparasitic AgentsCatalaseFatty Acids, UnsaturatedpellitorinePolyunsaturated AlkamidesReactive Oxygen SpeciesSuperoxide DismutaseAquacultureArgulusFish liceOxidative stressPellitorine

Identifiers

PMID38411855
OpenAlexW4392192803

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.