Evidence map›Paper›PMID 38411436›Full record

ArticleCancer biology & therapy2024

A mathematical model for predicting the spatiotemporal response of breast cancer cells treated with doxorubicin.

Hugo J M Miniere, Ernesto A B F Lima, Guillermo Lorenzo, David A Hormuth, Sophia Ty, Amy Brock, Thomas E Yankeelov

Abstract read
In one paragraph

Article in Cancer biology & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. 75 Years of Mathematical Oncology.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hugo J M MiniereDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, USA.
Ernesto A B F LimaOden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, USA.ORCID 0000-0002-9219-8784
Guillermo LorenzoOden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, USA.ORCID 0000-0001-9090-190X
David A HormuthOden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, USA.ORCID 0000-0002-9643-1694
Sophia TyDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, USA.
Amy BrockDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, USA.ORCID 0000-0001-8255-9024
Thomas E YankeelovDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, USA.ORCID 0000-0001-6201-3913

Funding

INTEGRATING OMICS AND QUANTITATIVE IMAGING DATA IN CO-CLINICAL TRIALS TO PREDICT TREATMENT RESPONSE IN TRIPLE NEGATIVE BREAST CANCERU24CA226110 · NCI · BAYLOR COLLEGE OF MEDICINE · PI LEWIS, MICHAEL T., RUBIN, DANIEL L · 2019 to 2023
$3.2M
Quantitative Multiscale Imaging to Optimize Cancer Treatment StrategiesR01CA186193 · NCI · VANDERBILT UNIVERSITY · PI QUARANTA, VITO, RERICHA, ERIN C · 2014 to 2019
$3.1M
Image Driven Multi-Scale Modeling to Predict Treatment Response in Breast CancerU01CA174706 · NCI · VANDERBILT UNIVERSITY · PI QUARANTA, VITO, YANKEELOV, THOMAS E · 2013 to 2018
$2.5M
Using label-free Raman microscopy to predict therapeutic resistance of TNBC cellsU01CA253540 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI BROCK, AMY, YANKEELOV, THOMAS E · 2020 to 2024
$2.1M
Personalizing immunotherapy in HER2+ breast cancer through quantitative imagingR01CA240589 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SORACE, ANNA C · 2020 to 2023
$1.6M
NCI NIH HHS R01 CA186193NCI NIH HHS R01 CA240589NCI NIH HHS U01 CA174706NCI NIH HHS U01 CA253540NCI NIH HHS U24 CA226110
6 · The paper itself

Abstract

Tumor heterogeneity contributes significantly to chemoresistance, a leading cause of treatment failure. To better personalize therapies, it is essential to develop tools capable of identifying and predicting intra- and inter-tumor heterogeneities. Biology-inspired mathematical models are capable of attacking this problem, but tumor heterogeneity is often overlooked in

Indexed as

Breast NeoplasmsCell CycleCell ProliferationDoxorubicinFemaleHumansMCF-7 CellsDoxorubicindata assimilationmathematical oncologymechanism-based modelingTime-resolved microscopy

Identifiers

PMID38411436
PMCPMC11057790

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.