ArticleEpilepsia2024
Patterns of subregional cerebellar atrophy across epilepsy syndromes: An ENIGMA-Epilepsy study.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Epilepsia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers, 2 of them syntheses that pooled it.
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17citing papers in PubMed, 2 pooled it
8.1field-weighted citation impact, top 2% of its field
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Imaging insights into temporal lobe epilepsy: an AES-SDM meta-analysis and retrospective cohort study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- Multimodal Analysis of Secondary Cerebellar Alterations After Pediatric Traumatic Brain Injury.JAMA network open · 2023Pooled it
- Local brain volume reductions in patients with non-lesional epilepsy on 7T MRI.Neuroradiology · 2026Article
- Quantifying cerebellar signal detectability in MEG and EEG in epilepsy using anatomically informed source modeling.NeuroImage · 2026Article
- Altered neurostructural development in magnetic resonance imaging-negative pediatric epilepsy: A large-scale multicenter study of 1919 children.Epilepsia · 2026Article
- Quantifying Cerebellar Signal Detectability in MEG and EEG in Epilepsy Using Anatomically Informed Source Modeling.bioRxiv : the preprint server for biology · 2026Article
- Changes in Cerebellar Functional Gradients and Molecular Genetic Mechanisms in Patients with Temporal Lobe Epilepsy: a cross-sectional and Longitudinal Functional Magnetic Resonance Imaging Study.Cerebellum (London, England) · 2025Article
- Early and widespread cerebellar engagement during hippocampal seizures and interictal discharges.Neurobiology of disease · 2025Article
- Minocycline in chronic management of febrile infection-related epilepsy syndrome (FIRES): a case series and literature review of treatment strategies.Acta epileptologica · 2025Review
- The cerebellum in epilepsy.Epilepsia · 2025Review
- Article
- Article
- Limited cerebellar gradient extension in temporal lobe epilepsy with dystonic posturing.Epilepsia open · 2024Article
- Molecular Mechanisms Underlying the Generation of Absence Seizures: Identification of Potential Targets for Therapeutic Intervention.International journal of molecular sciences · 2024Review
- Altered dynamic functional connectivity of motor cerebellum with sensorimotor network and default mode network in juvenile myoclonic epilepsy.Frontiers in neurology · 2024Article
- Cerebellar white and gray matter abnormalities in temporal lobe epilepsy: a voxel-based morphometry study.Frontiers in neuroscience · 2024Article
- Increased cerebellar vermis volume following repetitive transcranial magnetic stimulation in drug-resistant epilepsy: a voxel-based morphometry study.Frontiers in neuroscience · 2024Article
Corrections and comments
- Erratum issued
- Update of
Authors and funding
64 authors at 20 institutions in 10 countries.
Rebecca KerestesDepartment of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0003-1298-9904
Andrew PerryMonash Bioinformatics Platform, Monash University, Melbourne, Victoria, Australia.
Lucy VivashDepartment of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0002-1182-0907
Terence J O'BrienDepartment of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
Marina K M AlvimDepartment of Neurology, University of Campinas, Campinas, Brazil.
Donatello ArienzoDepartment of Psychiatry, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, California, USA.
Ítalo K AventuratoDepartment of Neurology, University of Campinas, Campinas, Brazil.
Alice BalleriniDepartment of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.ORCID https://orcid.org/0000-0002-0544-1599
Gabriel F BaltazarDepartment of Neurology, University of Campinas, Campinas, Brazil.
Núria BargallóMagnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain.
Benjamin BenderDepartment of Radiology, Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany.
Ricardo BrioschiDepartment of Neurology, University of Campinas, Campinas, Brazil.
Eva BürkleDepartment of Radiology, Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany.
Maria Eugenia CaligiuriNeuroscience Research Center, Department of Medical and Surgical Sciences, University "Magna Græcia" of Catanzaro, Catanzaro, Italy.ORCID https://orcid.org/0000-0002-2030-5552
Fernando CendesDepartment of Neurology, University of Campinas, Campinas, Brazil.ORCID https://orcid.org/0000-0001-9336-9568
Jane de TisiDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.
John S DuncanDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.
Jerome P EngelDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Sonya FoleyCardiff University Brain Research Imaging Centre, School of Psychology, Cardiff, UK.
Francesco FortunatoDepartment of Medical and Surgical Sciences, Institute of Neurology, University "Magna Græcia" of Catanzaro, Catanzaro, Italy.ORCID https://orcid.org/0000-0001-8395-7809
Antonio GambardellaNeuroscience Research Center, Department of Medical and Surgical Sciences, University "Magna Græcia" of Catanzaro, Catanzaro, Italy.ORCID https://orcid.org/0000-0001-7384-3074
Thea GiacominiDepartment of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.ORCID https://orcid.org/0000-0002-7802-8789
Renzo GuerriniMeyer Children's Hospital IRCCS, Florence, Italy.
Gerard HallSchool of Computing, Newcastle University, Newcastle Upon Tyne, UK.ORCID https://orcid.org/0000-0002-5212-7850
Khalid HamandiCardiff University Brain Research Imaging Centre, School of Psychology, Cardiff, UK.
Victoria Ives-DeliperiNeuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID https://orcid.org/0000-0003-2640-249X
Rafael B JoãoDepartment of Neurology, University of Campinas, Campinas, Brazil.
Simon S KellerInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.ORCID https://orcid.org/0000-0001-5247-9795
Benedict KleiserDepartment of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.ORCID https://orcid.org/0000-0002-7575-0020
Angelo LabateNeurophysiopathology and Movement Disorders Clinic, University of Messina, Messina, Italy.ORCID https://orcid.org/0000-0002-8827-7324
Matteo LengeMeyer Children's Hospital IRCCS, Florence, Italy.
Cassandra MarottaDepartment of Neurology, Alfred Health, Melbourne, Victoria, Australia.
Pascal MartinDepartment of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Mario Mascalchi"Mario Serio" Department of Clinical and Experimental Medical Sciences, University of Florence, Florence, Italy.
Stefano MelettiDepartment of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.ORCID https://orcid.org/0000-0003-0334-539X
Conor Owens-WaltonImaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.
Costanza B ParodiIRCCS Istituto "Giannina Gaslini", Genoa, Italy.ORCID https://orcid.org/0000-0002-4069-7792
Saül Pascual-DiazMagnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain.
David PowellMonash Bioinformatics Platform, Monash University, Melbourne, Victoria, Australia.
Jun RaoDepartment of Psychiatry, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, California, USA.
Michael RebsamenSupport Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0002-8441-1485
Johannes ReiterDepartment of Epileptology, University Hospital Bonn, Bonn, Germany.ORCID https://orcid.org/0000-0002-4235-8209
Antonella RivaIRCCS Istituto "Giannina Gaslini", Genoa, Italy.ORCID https://orcid.org/0000-0001-9152-5571
Theodor RüberDepartment of Epileptology, University Hospital Bonn, Bonn, Germany.ORCID https://orcid.org/0000-0002-6180-7671
Christian RummelSupport Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Freda SchefflerNeuroscience Institute, University of Cape Town, Cape Town, South Africa.
Mariasavina SeverinoIRCCS Istituto "Giannina Gaslini", Genoa, Italy.ORCID https://orcid.org/0000-0003-4730-5322
Lucas S SilvaDepartment of Neurology, University of Campinas, Campinas, Brazil.
Richard J StabaDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Dan J SteinSAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Pasquale StrianoDepartment of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.ORCID https://orcid.org/0000-0002-6065-1476
Peter N TaylorDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.ORCID https://orcid.org/0000-0003-2144-9838
Sophia I ThomopoulosImaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.
Domenico TortoraIRCCS Istituto "Giannina Gaslini", Genoa, Italy.
Anna Elisabetta VaudanoDepartment of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.ORCID https://orcid.org/0000-0002-6280-7526
Bernd WeberInstitute of Experimental Epileptology and Cognition Research, University of Bonn, Bonn, Germany.
Roland WiestSupport Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Gavin P WinstonDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.ORCID https://orcid.org/0000-0001-9395-1478
Clarissa L YasudaDepartment of Neurology, University of Campinas, Campinas, Brazil.
Hong ZhengImaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.
Carrie R McDonaldDepartment of Psychiatry, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, California, USA.
Sanjay M SisodiyaDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.ORCID https://orcid.org/0000-0002-1511-5893
Ian H HardingDepartment of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
Universidade Estadual de Campinas (UNICAMP) · BRIstituto Giannina Gaslini · ITNational Hospital for Neurology and Neurosurgery · GBUniversity of Southern California · USMagna Graecia University · ITMonash University · AUUniversity of Bern · CHUniversity of California System · USUniversity of Modena and Reggio Emilia · ITHertie Institute for Clinical Brain Research · DEMelbourne Bioinformatics · AUMeyer Children's Hospital · ITUniversity Hospital Bonn · DEUniversity of California, Los Angeles · USUniversity of Cape Town · ZAAlfred Health · AUCardiff University · GBCentro de Investigación Biomédica en Red de Salud Mental · ESInstitute on Governance · CANewcastle University · GB
Funding
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1MTranslational Platform for Epilepsy Therapy and Biomarker DiscoveryR01NS127524 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Denes V. Agoston, LISA D COLES · 2022 to 2026
$11.0MIN VIVO STUDIES OF THE EPILEPTIC HIPPOCAMPUSR01NS033310 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JEROME NONE ENGEL, Richard Staba · 1994 to 2026
$7.5MBRain Aging and Cognition in Epilepsy (BRACE): A longitudinal investigationof vascular, genetic, and biomarker risk profiles in elderly patients with epilepsyR01NS120976 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CARRIE R MCDONALD · 2021 to 2026
$4.1MLifespan Epilepsy Network Signatures (LENS): Leveraging ENIGMA-Epilepsy to Predict Cognitive Aging and Surgical OutcomesR01NS122827 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CARRIE R MCDONALD · 2021 to 2026
$3.8MIn Vivo Studies of the Epileptic HippocampusRF1NS033310 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ENGEL, JEROME NONE, STABA, RICHARD · 2023 to 2023
$3.6MDefining the Epileptogenic Network and Identifying Which Components Generate SeizuresR01NS106957 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Richard Staba · 2018 to 2026
$3.4MMultimodal imaging of memory in epilepsy from whole brain networks to local neuronal responses: Implications for surgical decision-makingR01NS124585 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCDONALD, CARRIE R · 2022 to 2025
$3.3MENIGMA World Aging CenterR01AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2021 to 2025
$3.3MENIGMA-SD: Understanding Sex Differences in Global Mental Health through ENIGMAR01MH116147 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2021
$2.5MHCRW_Medical Research Council G0802012Medical Research Council MR/M00841X/1Medical Research Council MR/S00355X/1NIA NIH HHS R01 AG058854NIBIB NIH HHS P41 EB015922NIH HHS P41EB015922NIH HHS R01AG058854NIH HHS R01MH116147NIH HHS R01 NS106957NIH HHS R01 NS1127524NIH HHS RF1 NS033310NIMH NIH HHS R01 MH116147NINDS NIH HHS R01 NS033310NINDS NIH HHS R01 NS106957NINDS NIH HHS R01 NS120976NINDS NIH HHS R01 NS122827NINDS NIH HHS R01 NS124585NINDS NIH HHS R01 NS127524Swiss National Science Foundation 180365
Abstract
objectiveThe intricate neuroanatomical structure of the cerebellum is of longstanding interest in epilepsy, but has been poorly characterized within the current corticocentric models of this disease. We quantified cross-sectional regional cerebellar lobule volumes using structural magnetic resonance imaging in 1602 adults with epilepsy and 1022 healthy controls across 22 sites from the global ENIGMA-Epilepsy working group.
methodsA state-of-the-art deep learning-based approach was employed that parcellates the cerebellum into 28 neuroanatomical subregions. Linear mixed models compared total and regional cerebellar volume in (1) all epilepsies, (2) temporal lobe epilepsy with hippocampal sclerosis (TLE-HS), (3) nonlesional temporal lobe epilepsy, (4) genetic generalized epilepsy, and (5) extratemporal focal epilepsy (ETLE). Relationships were examined for cerebellar volume versus age at seizure onset, duration of epilepsy, phenytoin treatment, and cerebral cortical thickness.
resultsAcross all epilepsies, reduced total cerebellar volume was observed (d = .42). Maximum volume loss was observed in the corpus medullare (d SIGNIFICANCE: We provide robust evidence of deep cerebellar and posterior lobe subregional gray matter volume loss in patients with chronic epilepsy. Volume loss was maximal for posterior subregions implicated in nonmotor functions, relative to motor regions of both the anterior and posterior lobe. Associations between cerebral and cerebellar changes, and variability of neuroanatomical profiles across epilepsy syndromes argue for more precise incorporation of cerebellar subregional damage into neurobiological models of epilepsy.
Indexed as
Epilepsy, Temporal LobeEpileptic SyndromesAdultAtrophyCerebellumCross-Sectional StudiesHumansMagnetic Resonance ImagingPhenytoinSeizuresPhenytoinanterior lobecerebellumepilepsyMRIposterior lobe
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