ArticleERJ open research2024
Global mortality and readmission rates following COPD exacerbation-related hospitalisation: a meta-analysis of 65 945 individual patients.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in ERJ open research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
15.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 37 citations in OpenAlex.
- GOLD-concordant inhaled maintenance therapy at hospital discharge after hospitalisation for severe COPD exacerbation: a multicentre retrospective observational study.The Lancet regional health. Europe · 2026Article
- Not All Flares Are Equal: Stratifying Risk During Asthma/COPD Overlap Exacerbations.Respirology (Carlton, Vic.) · 2026Article
- Article
- Implementing acute exacerbations of COPD care bundles: evidence, effectiveness and future directions.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Opportunistic Chest CT-Derived Body Composition for Predicting 90-Day Adverse Outcomes After Hospitalization for Acute Exacerbation of Chronic Obstructive Pulmonary Disease.The clinical respiratory journal · 2026Article
- Metagenomic Next-Generation Sequencing for Pulmonary Tuberculosis Diagnosis and Infection Risk Factor Analysis in AECOPD Patients: A Single-Center Retrospective Study.Journal of clinical medicine · 2026Article
- Is a Hybrid Pulmonary Rehabilitation Programme Feasible and Effective in Individuals With COPD After an Exacerbation-Related Hospitalisation: A Mixed Methods Study.Journal of clinical nursing · 2026Article
- Development and validation of PRECISE-X model: predicting first severe exacerbation in COPD.Thorax · 2026Article
- Predictive models for mortality readmission events and cardiovascular complications in patients with COPD: a systematic review and meta-analysis.ERJ open research · 2026Article
- Development and internal validation of a nomogram for predicting in-hospital mortality in patients with acute exacerbation of chronic obstructive pulmonary disease.Journal of thoracic disease · 2026Article
- Missed Opportunities in the Therapeutic Patterns of Chronic Obstructive Pulmonary Disease: A Real-World Italian Study on the Impact of Severe Exacerbation on Mortality and Hospital Re-admission.Clinical drug investigation · 2026Article
- Nationwide trends in AECOPD care in Italy before, during and after COVID-19: discrepancies between data sources and across regions.BMJ open respiratory research · 2026Article
- Evaluating Changes in Physical Activity and Clinical Outcomes During Post-Hospitalisation Rehabilitation for Persons with COPD: A Prospective Observational Cohort Study.Sensors (Basel, Switzerland) · 2026Observational
- Variation in inpatient investigations and treatment practices for COPD exacerbations between respiratory and internal medicine specialties: a retrospective cohort study.Frontiers in medicine · 2026Article
- Admission Systemic Immune-Inflammation Index and 90-Day AECOPD-Related Unplanned Readmission: A Single-Center Retrospective Cohort Study.International journal of chronic obstructive pulmonary disease · 2026Article
- Effect of music-guided breathing training combined with singing on pulmonary rehabilitation in COPD patients: a randomized controlled trial protocol.Frontiers in public health · 2026Article
- Baseline Blood Eosinophil Count and 28-Day in-Hospital Mortality in ICU-Admitted Patients with AECOPD: A Cohort Study with External Validation.International journal of chronic obstructive pulmonary disease · 2026Article
- The interaction between illness perception and intrinsic capacity during hospital-to-home transition in older adults with COPD and diabetes: a prospective cohort study.Frontiers in medicine · 2026Article
- Clinical outcomes associated with Shenling Bufei Tongluo Decoction as add-on therapy in stable COPD patients with a frequent-exacerbator phenotype: a retrospective real-world cohort study.Frontiers in medicine · 2026Article
- Treatable moments for smoking cessation in asthma and COPD: a nationwide cohort study.BMJ open respiratory research · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
55 authors at 20 institutions in 21 countries.
Kiki Waeijen-SmitDepartment of Research and Development, Ciro, Horn, the Netherlands.
Mieke CrutsenPulmonary Function and Exercise Testing Laboratory, MUMC+, Maastricht, the Netherlands.
Spencer KeeneDepartment of Research and Development, Ciro, Horn, the Netherlands.
Marc MiravitllesPneumology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca, Vall d'Hebron Barcelona Hospital Campus, Ciber de Enfermedades Respiratorias (CIBERES), Barcelona, Spain.ORCID https://orcid.org/0000-0002-9850-9520
Ernesto CrisafulliRespiratory Medicine Unit, Department of Medicine, University of Verona, Verona, Italy.ORCID https://orcid.org/0000-0001-7298-7084
Antoni TorresDepartment of Pulmonology, Hospital Clinic of Barcelona and University of Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer, Institución Catalana de Investigación y Estudios Avanzados, CIBERES, Barcelona, Spain.ORCID https://orcid.org/0000-0002-8643-2167
Christian MuellerCardiovascular Research Institute Base, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Philipp SchuetzMedical University Department, Kantonsspital Aarau, Aarau, Switzerland.
Thomas J RingbækDepartment of Respiratory Medicine, Copenhagen University Hospital-Hvidovre, Hvidovre, Denmark.
Fabio FabbianDepartment of Medical Sciences, Faculty of Medicine, Pharmacy and Prevention, University of Ferrara, University Hospital of Ferrara, Ferrara, Italy.
Evgeni MekovDepartment of Occupational Diseases, Medical University Sofia, Sofia, Bulgaria.ORCID https://orcid.org/0000-0002-4410-6515
Timothy H HarriesDepartment of Population Health Sciences, School of Life Course and Population Sciences, King's College London, London, UK.
Chung-Tat LunDepartment of Medicine and ICU, Alice Ho Miu Ling Nethersole Hospital, Hong Kong, Hong Kong.
Begum ErganDokuz Eylul University, Faculty of Medicine, Department of Pulmonary and Critical Care, Division of Critical Care, Izmir, Turkey.ORCID https://orcid.org/0000-0003-2920-9214
Cristóbal EstebanRespiratory Department, Hospital Galdakao, Galdakao, Spain.
Jose M Quintana LopezRed de Investigación en Servicios Sanitarios y Enfermedades Crónicas, Red de Investigación en Cronicidad, Atención Primaria y Promoción de la Salud, Bizkaia, Spain.ORCID https://orcid.org/0000-0003-2170-7876
José Luis López-CamposUnidad Médico-Quirúrgica de Enfermedades Respiratorias, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/Universidad de Sevilla, Seville, Spain.ORCID https://orcid.org/0000-0003-1703-1367
Catherina L ChangDepartment of Respiratory Medicine, Waikato Hospital, Hamilton, New Zealand.ORCID https://orcid.org/0000-0002-8390-670X
Robert J HancoxDepartment of Respiratory Medicine, Waikato Hospital, Hamilton, New Zealand.ORCID https://orcid.org/0000-0002-3922-7144
Eskandarain ShafuddinDepartment of Respiratory Medicine, Waikato Hospital, Hamilton, New Zealand.
Hollie EllisDepartment of Respiratory Medicine, Waikato Hospital, Hamilton, New Zealand.
Christer JansonDepartment of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.ORCID https://orcid.org/0000-0001-5093-6980
Charlotte Suppli UlrikDepartment of Respiratory Medicine, Copenhagen University Hospital-Hvidovre, Hvidovre, Denmark.ORCID https://orcid.org/0000-0001-8689-3695
Gunnar GudmundssonLandspitali - The National University Hospital of Iceland, Reykjavik, Iceland.
Danny EpsteinCritical Care Division, Rambam Health Care Campus, Haifa, Israel.
José DominguezServei de Microbiologia, Hospital Universitari Germans Trias i Pujol, Institut d'Investigació Germans Trias i Pujol, Universitat Autònoma de Barcelona, CIBERES, Barcelona, Spain.
Alicia LacomaServei de Microbiologia, Hospital Universitari Germans Trias i Pujol, Institut d'Investigació Germans Trias i Pujol, Universitat Autònoma de Barcelona, CIBERES, Barcelona, Spain.ORCID https://orcid.org/0000-0002-2049-3872
Christian OsadnikDepartment of Physiotherapy, Monash University, Clayton, Australia.ORCID https://orcid.org/0000-0001-9040-8007
Inmaculada AliaIntensive Care Units, Hospital Universitario de Getafe, CIBERES, Getafe, Spain.
Francesco SpannellaInternal Medicine and Geriatrics, Hypertension Excellence Centre of the European Society of Hypertension, IRCCS INRCA, Ancona, Italy.
Zuhal KarakurtRespiratory Critical Care Unit, University of Health Sciences Istanbul Sureyyapasa Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey.
Hossein MehravaranPulmonary and Critical Care Division, Department of Internal Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Cecile UtensLibra, Rehabilitation and Audiology, Eindhoven, the Netherlands.
Martijn D de KruifDepartment of Pulmonary Medicine, Zuyderland Medical Center, Heerlen, The Netherlands.
Fanny Wai San KoDepartment of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong.ORCID https://orcid.org/0000-0001-8454-0087
Samuel P TretheweyGloucestershire Hospitals NHS Foundation Trust, Cheltenham, UK.ORCID https://orcid.org/0000-0003-0150-2283
Alice M TurnerInstitute for Applied Health Research, University of Birmingham, Birmingham, UK.ORCID https://orcid.org/0000-0002-5947-3254
Dragos BumbaceaDepartment of Pneumology and Acute Respiratory Care, Elias Emergency University Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.ORCID https://orcid.org/0000-0002-2509-3835
Patrick B MurphyLane Fox Unit, Guy's and St Thomas' NHS Foundation Trust, London, UK.ORCID https://orcid.org/0000-0002-1500-611X
Kristina VermeerschDepartment of Chronic Diseases, Metabolism and Ageing, Research Group BREATHE, KU Leuven, Leuven, Belgium.
Shani Zilberman-ItskovichNephrology Division, Assaf-Harofeh (Shamir) Medical Center, Be'er Ya'akov, Israel.
John SteerTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Carlos EchevarriaTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Stephen C BourkeTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Nicholas LaneTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID https://orcid.org/0000-0002-9954-6366
Jordi de BatlleGroup of Translational Research in Respiratory Medicine, Institut de Recerca Biomèdica de Lleida (Fundació Dr Pifarré), Lleida, Spain.
Roy T M SprootenDepartment of Respiratory Medicine, MUMC+, Maastricht, The Netherlands.
Richard RussellSchool of Immunology and Microbial Sciences, Guy's Campus, Kings College, London, UK.ORCID https://orcid.org/0000-0002-3890-7201
Paola FaverioSchool of Medicine and Surgery, University of Milan Bicocca, Respiratory Unit, San Gerardo Hospital, ASST Monza, Monza, Italy.
Jane L CrossFaculty of Medicine and Health, University of East Anglia, Norwich, UK.
Hendrik J PrinsDepartment of PMR, Libra, Rehabilitation and Audiology, Eindhoven, The Netherlands.
Martijn A SpruitDepartment of Research and Development, Ciro, Horn, the Netherlands.ORCID https://orcid.org/0000-0003-3822-7430
Sami O SimonsDepartment of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Faculty of Health Medicine and Life Sciences, Maastricht University Medical Centre (MUMC+), Maastricht, the Netherlands.ORCID https://orcid.org/0000-0002-4296-5076
Sarah Houben-WilkeDepartment of Research and Development, Ciro, Horn, the Netherlands.
Frits M E FranssenDepartment of Research and Development, Ciro, Horn, the Netherlands.ORCID https://orcid.org/0000-0002-1633-6356
Maastricht University Medical Centre · NLWaikato Hospital · NZCentro de Investigación Biomédica en Red de Enfermedades Respiratorias · ESKing's College London · GBNorth Tyneside General Hospital · GBRoyal Victoria Infirmary · GBUniversitat Autònoma de Barcelona · ESUniversity of Basel · CHAlice Ho Miu Ling Nethersole Hospital · CNBioCruces Health research Institute · ESCarol Davila University of Medicine and Pharmacy · ROChinese University of Hong Kong · HKCiro · NLDokuz Eylül University · TRHvidovre Hospital · DKInstitució Catalana de Recerca i Estudis Avançats · ESInstituto de Salud Carlos III · ESKantonsspital Aarau · CHKU Leuven · BELibra Revalidatie & Audiologie · NL
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Exacerbations of COPD (ECOPD) have a major impact on patients and healthcare systems across the world. Precise estimates of the global burden of ECOPD on mortality and hospital readmission are needed to inform policy makers and aid preventive strategies to mitigate this burden. The aims of the present study were to explore global in-hospital mortality, post-discharge mortality and hospital readmission rates after ECOPD-related hospitalisation using an individual patient data meta-analysis (IPDMA) design. Methods: A systematic review was performed identifying studies that reported in-hospital mortality, post-discharge mortality and hospital readmission rates following ECOPD-related hospitalisation. Data analyses were conducted using a one-stage random-effects meta-analysis model. This study was conducted and reported in accordance with the PRISMA-IPD statement. Results: Data of 65 945 individual patients with COPD were analysed. The pooled in-hospital mortality rate was 6.2%, pooled 30-, 90- and 365-day post-discharge mortality rates were 1.8%, 5.5% and 10.9%, respectively, and pooled 30-, 90- and 365-day hospital readmission rates were 7.1%, 12.6% and 32.1%, respectively, with noticeable variability between studies and countries. Strongest predictors of mortality and hospital readmission included noninvasive mechanical ventilation and a history of two or more ECOPD-related hospitalisations <12 months prior to the index event. Conclusions: This IPDMA stresses the poor outcomes and high heterogeneity of ECOPD-related hospitalisation across the world. Whilst global standardisation of the management and follow-up of ECOPD-related hospitalisation should be at the heart of future implementation research, policy makers should focus on reimbursing evidence-based therapies that decrease (recurrent) ECOPD.
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.