Evidence map›Paper›PMID 38410509›Full record

ArticleFrontiers in immunology2024

Bacterial small RNAs may mediate immune response differences seen in respiratory syncytial virus versus rhinovirus bronchiolitis.

Kylie I Krohmaly, Marcos Perez-Losada, Ignacio Ramos-Tapia, Zhaozhong Zhu, Kohei Hasegawa, Carlos A Camargo, Brennan Harmon, Janice A Espinola, Laura Reck Cechinel, Rachael Batabyal and 2 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Single-Cell Insights Into Macrophage Subtypes in Pulmonary Infections.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  2. Review
  3. The role of virus in nasal inflammation.European journal of medical research · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Kylie I KrohmalyIntegrated Biomedical Sciences, The George Washington University, Washington, DC, United States.
Marcos Perez-LosadaDepartment of Biostatistics and Bioinformatics, Computational Biology Institute, The George Washington University, Washington, DC, United States.
Ignacio Ramos-TapiaCentro de Bioinformática y Biología Integrativa, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago, Chile.
Zhaozhong ZhuDepartment of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Kohei HasegawaDepartment of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Carlos A CamargoDepartment of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Brennan HarmonCenter for Genetic Medicine Research, Children's National Research and Innovation Center, Washington, DC, United States.
Janice A EspinolaDepartment of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Laura Reck CechinelCenter for Genetic Medicine Research, Children's National Research and Innovation Center, Washington, DC, United States.
Rachael BatabyalCenter for Genetic Medicine Research, Children's National Research and Innovation Center, Washington, DC, United States.
Robert J FreishtatCenter for Genetic Medicine Research, Children's National Research and Innovation Center, Washington, DC, United States.
Andrea HahnCenter for Genetic Medicine Research, Children's National Research and Innovation Center, Washington, DC, United States.
Children's National · USHarvard University · USGeorge Washington University · USMassachusetts General Hospital · USUniversidad Andrés Bello · CL

Funding

Nasal microRNA during bronchiolitis and age 6y asthma phenotypes: MARC-35 cohortR01AI127507 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI CAMARGO, CARLOS ARTURO, FREISHTAT, ROBERT J · 2017 to 2021
$8.0M
Prospective Cohort Study of Severe Bronchiolitis and Risk of Recurrent WheezingU01AI087881 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI CAMARGO, CARLOS ARTURO · 2011 to 2016
$6.2M
Airway dual-transcriptomics in bronchiolitis and risk of asthma: MARC-35 cohortR01AI137091 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HASEGAWA, KOHEI · 2018 to 2022
$4.3M
Airway metagenome & metabolome in bronchiolitis and risk of asthma: MARC-35 cohortR01AI134940 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HASEGAWA, KOHEI · 2018 to 2022
$4.0M
Integrating the genome, metabolome, and microbiome for childhood asthma: Risk and endotypesK01AI153558 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI ZHU, ZHAOZHONG · 2021 to 2025
$663k
NIAID NIH HHS K01 AI153558NIAID NIH HHS R01 AI127507NIAID NIH HHS R01 AI134940NIAID NIH HHS R01 AI137091NIAID NIH HHS U01 AI087881
6 · The paper itself

Abstract

Bronchiolitis, a viral lower respiratory infection, is the leading cause of infant hospitalization, which is associated with an increased risk for developing asthma later in life. Bronchiolitis can be caused by several respiratory viruses, such as respiratory syncytial virus (RSV), rhinovirus (RV), and others. It can also be caused by a solo infection (e.g., RSV- or RV-only bronchiolitis) or co-infection with two or more viruses. Studies have shown viral etiology-related differences between RSV- and RV-only bronchiolitis in the immune response, human microRNA (miRNA) profiles, and dominance of certain airway microbiome constituents. Here, we identified bacterial small RNAs (sRNAs), the prokaryotic equivalent to eukaryotic miRNAs, that differ between infants of the 35

Indexed as

BronchiolitisEnterovirus InfectionsMicroRNAsRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsVirusesHumansImmunityInfantRhinovirusRNA, BacterialMicroRNAsRNA, Bacterialbronchiolitisextra cellular vesiclesHaemophilus influenzaerespiratory syncytial virusrhinovirusRNAStreptococcus pneumoniae

Identifiers

PMID38410509
PMCPMC10895043
OpenAlexW4391750538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.