Evidence map›Paper›PMID 38410471›Full record

ArticlebioRxiv : the preprint server for biology2024

Presynaptic Nrxn3 is essential for ribbon-synapse assembly in hair cells.

Alma Jukic, Zhengchang Lei, Elizabeth R Cebul, Katherine Pinter, Natalie Mosqueda, Sandeep David, Basile Tarchini, Katie Kindt

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Alma JukicSection on Sensory Cell Development and Function, National Institute on Deafness and Other Communication Disorders, Bethesda, MD, 20892, USA.
Zhengchang LeiSection on Sensory Cell Development and Function, National Institute on Deafness and Other Communication Disorders, Bethesda, MD, 20892, USA.
Elizabeth R CebulSection on Sensory Cell Development and Function, National Institute on Deafness and Other Communication Disorders, Bethesda, MD, 20892, USA.ORCID 0000-0001-5218-265X
Katherine PinterSection on Sensory Cell Development and Function, National Institute on Deafness and Other Communication Disorders, Bethesda, MD, 20892, USA.
Natalie MosquedaSection on Sensory Cell Development and Function, National Institute on Deafness and Other Communication Disorders, Bethesda, MD, 20892, USA.ORCID 0000-0002-3860-6759
Sandeep DavidSection on Sensory Cell Development and Function, National Institute on Deafness and Other Communication Disorders, Bethesda, MD, 20892, USA.
Basile TarchiniThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.ORCID 0000-0003-2708-6273
Katie KindtSection on Sensory Cell Development and Function, National Institute on Deafness and Other Communication Disorders, Bethesda, MD, 20892, USA.ORCID 0000-0002-1065-8215
National Institute on Deafness and Other Communication Disorders · USJackson Laboratory · US

Funding

In vivo investigation of sensory hair cell function and developmentZIADC000085 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI KINDT, KATIE · 2014 to 2025
$21.4M
Hair Cell Polarization and Sensory Bundle DevelopmentR01DC015242 · NIDCD · JACKSON LABORATORY · PI Basile Robin Tarchini · 2017 to 2026
$5.4M
Mechanism and Functional Significance of Polarity Reversal in Mechanosensory OrgansR01DC018304 · NIDCD · JACKSON LABORATORY · PI CULLEN, KATHLEEN E, EATOCK, RUTH ANNE · 2020 to 2024
$3.5M
Fluorender: An Imaging Tool for Visualization and Analysis of Confocal Data as ApR01GM098151 · NIGMS · UNIVERSITY OF UTAH · PI HANSEN, CHARLES · 2011 to 2014
$1.2M
Intramural NIH HHS ZIA DC000085NIDCD NIH HHS R01 DC015242NIDCD NIH HHS R01 DC018304NIGMS NIH HHS R01 GM098151
6 · The paper itself

Abstract

Hair cells of the inner ear rely on specialized ribbon synapses to transmit sensory information to the central nervous system. The molecules required to assemble these synapses are not fully understood. We show that Nrxn3, a presynaptic adhesion molecule, is critical for ribbon-synapse assembly in hair cells. In both mouse and zebrafish models, loss of Nrxn3 results in significantly fewer intact ribbon synapses. In zebrafish we demonstrate that a 60% loss of synapses in

Indexed as

hair cellNeurexin3sensory systemssynapse formationzebrafish

Identifiers

PMID38410471
PMCPMC10896334
OpenAlexW4391846125

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.