Evidence map›Paper›PMID 38410458›Full record

ArticleResearch square2024

Early generation of a precursor CD8 T cell that can adapt to acute or chronic viral infection.

Daniel T McManus, Rajesh M Valanparambil, Christopher B Medina, Yinghong Hu, Christopher D Scharer, Ewelina Sobierajska, Daniel Y Chang, Andreas Wieland, Judong Lee, Tahseen H Nasti and 12 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 5 institutions in 1 country.

Daniel T McManusEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Rajesh M ValanparambilEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Christopher B MedinaEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Yinghong HuEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Christopher D ScharerDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0001-7716-8504
Ewelina SobierajskaDepartment of Urology, Emory University School of Medicine, Atlanta, GA, USA.
Daniel Y ChangDepartment of Pathology, Mass General Brigham, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-8766-3768
Andreas WielandDepartment of Otolaryngology, The Ohio State University College of Medicine, Columbus, OH.ORCID 0000-0001-9648-7922
Judong LeeEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-7064-1079
Tahseen H NastiEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Masao HashimotoEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
James L RossEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Nataliya ProkhnevskaThe Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Maria A CardenasDepartment of Urology, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-8566-9576
Amanda L GillEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0001-5827-8265
Elisa C ClarkDepartment of Bioengineering, University of Washington, Seattle, WA, USA.ORCID 0000-0003-4267-7215
Kathleen AbadieDepartment of Bioengineering, University of Washington, Seattle, WA, USA.ORCID 0000-0003-2021-7365
Hao Yuan KuehDepartment of Bioengineering, University of Washington, Seattle, WA, USA.ORCID 0000-0001-6272-6673
Jonathan KayeResearch Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Byron B Au-YeungDivision of Immunology, Lowance Center for Human Immunology, Department of Medicine, Emory University, Atlanta, GA.
Haydn T KissickEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0001-7624-5598
Rafi AhmedEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-9591-2621
Emory University · USUniversity of Washington · USCedars-Sinai Medical Center · USHarvard University · USThe Ohio State University · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Medical Scientist Training ProgramT32GM142617 · NIGMS · EMORY UNIVERSITY · PI Jason Yustein · 2022 to 2026
$7.0M
T CELL MEMORY TO VIRUSESR01AI030048 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AHMED, RAFI · 1990 to 2022
$5.2M
Regulation of CD4 T cell tolerance by the NR4A family of nuclear receptorsR01AI165706 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JULIE ZIKHERMAN · 2022 to 2026
$3.0M
Input encoding in T-cell receptor signalingR21EB027327 · NIBIB · UNIVERSITY OF WASHINGTON · PI KUEH, HAO YUAN · 2019 to 2021
$622k
NIAID NIH HHS R01 AI030048NIAID NIH HHS R01 AI165706NIBIB NIH HHS R21 EB027327NIGMS NIH HHS T32 GM142617NIH HHS P51 OD011132
6 · The paper itself

Abstract

Virus specific PD-1+ TCF-1+ TOX+ stem-like CD8+ T cells are essential for maintaining T cell responses during chronic infection and are also critical for PD-1 directed immunotherapy. In this study we have used the mouse model of chronic LCMV infection to examine when these virus specific stem-like CD8+ T cells are generated during the course of chronic infection and what is the role of antigen in maintaining the stem-like program. We found that these stem-like CD8+ T cells are generated early (day 5) during chronic infection and that antigen is essential for maintaining their stem-like program. This early generation of stem-like CD8+ T cells suggested that the fate commitment to this cell population was agnostic to the eventual outcome of infection and the immune system prepares

Identifiers

PMID38410458
PMCPMC10896375
OpenAlexW4391753567

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.