ArticlemedRxiv : the preprint server for health sciences2024
Differences in polygenic score distributions in European ancestry populations: implications for breast cancer risk prediction.
Abstract readPreprint
In one paragraph
Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Updated by
Authors and funding
130 authors.
Kristia YiangouBiostatistics Unit, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus, 2371.ORCID 0009-0005-2559-9747
Nasim MavaddatCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK, CB1 8RN.
Joe DennisCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK, CB1 8RN.
Maria ZantiBiostatistics Unit, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus, 2371.ORCID 0000-0002-0136-9921
Qin WangCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK, CB1 8RN.
Manjeet K BollaCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK, CB1 8RN.
Mustapha AbubakarDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA, 20850.
Thomas U AhearnDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA, 20850.
Irene L AndrulisFred A, Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada, M5G 1X5.
Hoda Anton-CulverDepartment of Medicine, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA, USA, 92617.
Natalia N AntonenkovaNN Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus, 223040.
Volker ArndtDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany, 69120.
Kristan J AronsonDepartment of Public Health Sciences, and Cancer Research Institute, Queen's University, Kingston, ON, Canada, K7L 3N6.
Annelie AugustinssonOncology, Clinical Sciences in Lund, Lund University, Lund, Sweden, 221 85.
Adinda BatenLeuven Multidisciplinary Breast Center, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium, 3000.
Sabine BehrensDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 69120.
Marina BermishevaInstitute of Biochemistry and Genetics of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia, 450054.
Amy Berrington de GonzalezDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK, SM2 5NG.
Katarzyna BiałkowskaDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland, 71-252.
Nicholas BoddickerDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA, 55905.
Clara BodelonDepartment of Population Science, American Cancer Society, Atlanta, GA, USA, 30303.
Natalia V BogdanovaNN Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus, 223040.
Stig E BojesenCopenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark, 2730.
Kristen D BrantleyDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA, 02115.
Hiltrud BrauchDr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany, 70376.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany, 69120.
Nicola J CampDepartment of Internal Medicine and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA, 84112.
Federico CanzianGenomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany, 69120.
Jose E CastelaoOncology and Genetics Unit, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS) Foundation, Complejo Hospitalario Universitario de Santiago, SERGAS, Vigo, Spain, 36312.
Melissa H CessnaDepartment of Pathology, Intermountain Healthcare, Salt Lake City, UT, USA, 84143.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 69120.
Georgia Chenevix-TrenchCancer Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia, 4006.ORCID 0000-0002-1878-2587
Wendy K ChungDepartments of Pediatrics and Medicine, Columbia University, New York, NY, USA, 10032.
NBCS Collaborators
Sarah V ColonnaDepartment of Internal Medicine and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA, 84112.
Fergus J CouchDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA, 55905.
Angela CoxDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK, S10 2TN.
Simon S CrossDivision of Neuroscience, School of Medicine and Population Health, University of Sheffield, Sheffield, UK, S10 2TN.
Kamila CzeneDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, 171 65.
Mary B DalyDepartment of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, USA, 19111.
Peter DevileeDepartment of Pathology, Leiden University Medical Center, Leiden, the Netherlands, 2333 ZA.
Thilo DörkGynaecology Research Unit, Hannover Medical School, Hannover, Germany, 30625.
Alison M DunningCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK, CB1 8RN.
Diana M EcclesFaculty of Medicine, University of Southampton, Southampton, UK, SO17 1BJ.
A Heather EliassenDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA, 02115.
Christoph EngelInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany, 04107.
Mikael ErikssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, 171 65.
D Gareth EvansDivision of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK, M13 9WL.
Peter A FaschingDepartment of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany, 91054.
Olivia FletcherThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK, SW7 3RP.
Henrik FlygerDepartment of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark, 2730.
Lin FritschiSchool of Population Health, Curtin University, Perth, Western Australia, Australia, 6102.
Manuela Gago-DominguezCancer Genetics and Epidemiology Group, Genomic Medicine Group, Fundación Instituto de Investigación Sanitaria de Santiago de Compostela (FIDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain, 15706.
Aleksandra Gentry-MaharajMRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, UK, WC1V 6LJ.
Anna González-NeiraHuman Genotyping Unit-CeGen, Spanish National Cancer Research Centre (CNIO), Madrid, Spain, 28029.
Pascal GuénelTeam 'Exposome and Heredity', CESP, Gustave Roussy, INSERM, University Paris-Saclay, UVSQ, Villejuif, France, 94805.
Eric HahnenCenter for Familial Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany, 50937.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA, 90033.
Ute HamannMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany, 69120.
Jaana M HartikainenCancer RC, University of Eastern Finland, Kuopio, Finland, 70210.
Vikki HoHealth Innovation and Evaluation Hub, Université de Montréal Hospital Research Centre (CRCHUM), Montréal, Québec, Canada.
James HodgeDepartment of Population Science, American Cancer Society, Atlanta, GA, USA, 30303.
Antoinette HollestelleDepartment of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands, 3015 GD.
Ellen HonischDepartment of Gynecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany, 40225.
Maartje J HooningDepartment of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands, 3015 GD.
Reiner HoppeDr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany, 70376.
John L HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia, 3010.
Sacha HowellDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Anthony HowellDivision of Cancer Sciences, University of Manchester, Manchester, UK, M13 9PL.
ABCTB Investigators
kConFab Investigators
Simona JakovchevskaResearch Centre for Genetic Engineering and Biotechnology 'Georgi D, Efremov', MASA, Skopje, Republic of North Macedonia, 1000.
Anna JakubowskaDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland, 71-252.ORCID 0000-0002-5650-0501
Helena JernströmOncology, Clinical Sciences in Lund, Lund University, Lund, Sweden, 221 85.
Nichola JohnsonThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK, SW7 3RP.
Rudolf KaaksDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 69120.
Elza K KhusnutdinovaInstitute of Biochemistry and Genetics of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia, 450054.
Cari M KitaharaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA, 20892.
Stella KoutrosDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA, 20850.
Vessela N KristensenInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway, 0450.
James V LaceyDepartment of Computational and Quantitative Medicine, City of Hope, Duarte, CA, USA, 91010.
Diether LambrechtsLaboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium, 3000.
Flavio LejbkowiczCarmel Medical Center, Haifa, Israel.
Annika LindblomDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, 171 76.
Michael LushCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK, CB1 8RN.
Arto MannermaaInstitute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland, 70210.
Dimitrios MavroudisDepartment of Medical Oncology, University Hospital of Heraklion, Heraklion, Greece, 711 10.
Usha MenonMRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, UK, WC1V 6LJ.ORCID 0000-0003-3708-1732
Rachel A MurphySchool of Population and Public Health, University of British Columbia, Vancouver, BC, Canada, V6T 1Z4.
Heli NevanlinnaDepartment of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland, 00290.
Nadia ObiInstitute for Occupational and Maritime Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 20246.
Kenneth OffitClinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA, 10065.
Tjoung-Won Park-SimonGynaecology Research Unit, Hannover Medical School, Hannover, Germany, 30625.
Alpa V PatelDepartment of Population Science, American Cancer Society, Atlanta, GA, USA, 30303.
Cheng PengChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, 02115.
Paolo PeterlongoGenome Diagnostics Program, IFOM ETS - the AIRC Institute of Molecular Oncology, Milan, Italy, 20139.ORCID 0000-0001-6951-6855
Guillermo PitaHuman Genotyping Unit-CeGen, Spanish National Cancer Research Centre (CNIO), Madrid, Spain, 28029.
Dijana Plaseska-KaranfilskaResearch Centre for Genetic Engineering and Biotechnology 'Georgi D, Efremov', MASA, Skopje, Republic of North Macedonia, 1000.ORCID 0000-0001-8877-2416
Katri PylkäsLaboratory of Cancer Genetics and Tumor Biology, Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland, 90220.
Paolo RadiceUnit of Predictice Medicine, Molecular Bases of Genetic Risk, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy, 20133.ORCID 0000-0001-6298-4111
Muhammad U RashidMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany, 69120.
Gad RennertTechnion, Faculty of Medicine and Association for Promotion of Research in Precision Medicine, Haifa, Israel.ORCID 0000-0002-8512-068X
Eleanor RobertsDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Juan RodriguezDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, 171 65.
Atocha RomeroMedical Oncology Department, Hospital Universitario Puerta de Hierro, Madrid, Spain, 28222.
Efraim H RosenbergDepartment of Pathology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Amsterdam, the Netherlands, 1066 CX.
Emmanouil SaloustrosDepartment of Oncology, University Hospital of Larissa, Larissa, Greece, 411 10.
Dale P SandlerEpidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA, 27709.
Elinor J SawyerSchool of Cancer & Pharmaceutical Sciences, Comprehensive Cancer Centre, Guy's Campus, King's College London, London, UK.
Rita K SchmutzlerCenter for Familial Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany, 50937.
Christopher G ScottDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA, 55905.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA, 37232.
Melissa C SoutheyPrecision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia, 3168.
Jennifer StoneCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia, 3010.
Jack A TaylorEpidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA, 27709.
Lauren R TerasDepartment of Population Science, American Cancer Society, Atlanta, GA, USA, 30303.
Irma van de BeekDepartment of Clinical Genetics, The Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Amsterdam, the Netherlands, 1066 CX.
Walter WillettDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA, 02115.
Robert WinqvistLaboratory of Cancer Genetics and Tumor Biology, Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland, 90220.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA, 37232.
Celine M VachonDepartment of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA, 55905.
Marjanka K SchmidtDivision of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands, 1066 CX.
Per HallDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, 171 65.
Robert J MacInnisCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia, 3010.
Roger L MilneCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia, 3010.
Paul D P PharoahDepartment of Computational Biomedicine, Cedars-Sinai Medical Center, West Hollywood, CA, USA, 90069.
Jacques SimardGenomics Center, Centre Hospitalier Universitaire de Québec - Université Laval Research Center, Québec City, Québec, Canada, G1V 4G2.
Antonis C AntoniouCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK, CB1 8RN.
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK, CB1 8RN.
Kyriaki MichailidouBiostatistics Unit, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus, 2371.ORCID 0000-0001-7065-1237
Funding
Training Program in Cancer EpidemiologyT32CA009001 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI A. Heather Eliassen, Meir Stampfer · 1985 to 2026
$17.3MCancer Research UK 16563NCI NIH HHS T32 CA009001
Abstract
The 313-variant polygenic risk score (PRS
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.