Evidence map›Paper›PMID 38410440›Full record

ArticleResearch square2024

Short-chain fatty acids propionate and butyrate control growth and differentiation linked to cellular metabolism.

Michael Nshanian, Benjamin S Geller, Joshua J Gruber, Faye Chleilat, Jeannie Marie Camarillo, Neil L Kelleher, Yingming Zhao, Michael P Snyder

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Michael NshanianDepartment of Genetics, Stanford University, School of Medicine, Stanford, CA.ORCID 0000-0003-3461-5700
Benjamin S GellerDepartment of Genetics, Stanford University, School of Medicine, Stanford, CA.
Joshua J GruberDepartment of Genetics, Stanford University, School of Medicine, Stanford, CA.
Faye ChleilatDepartment of Genetics, Stanford University, School of Medicine, Stanford, CA.
Jeannie Marie CamarilloDepartment of Chemistry, Molecular Biosciences and Proteomics Center of Excellence, Northwestern University, Evanston, IL.
Neil L KelleherDepartment of Chemistry, Molecular Biosciences and Proteomics Center of Excellence, Northwestern University, Evanston, IL.
Yingming ZhaoBen May Department of Cancer Research Committee on Cancer Biology, University of Chicago; Chicago, IL.
Michael P SnyderDepartment of Genetics, Stanford University, School of Medicine, Stanford, CA.ORCID 0000-0003-0784-7987
Stanford Medicine · USNorthwestern University · USUniversity of Chicago · US

Funding

PRODUCTION CENTER FOR MAPPING REGULATORY REGIONS OF THE HUMAN GENOMEUM1HG009442 · NHGRI · STANFORD UNIVERSITY · PI SNYDER, MICHAEL P. · 2017 to 2021
$20.1M
Ultra high throughput sequencer for sustaining and enhancing multi-scale genomic studiesS10OD025212 · OD · STANFORD UNIVERSITY · PI SNYDER, MICHAEL P. · 2018 to 2018
$600k
Computer ClusterS10OD021763 · OD · STANFORD UNIVERSITY · PI JI, HANLEE P · 2016 to 2016
$481k
NHGRI NIH HHS UM1 HG009442NIH HHS S10 OD021763NIH HHS S10 OD025212
6 · The paper itself

Abstract

The short-chain fatty acids (SCFA) propionate and butyrate are produced in large amounts by microbial metabolism and have been identified as unique acyl lysine histone marks. In order to better understand the function of these modifications we used ChIP-seq to map the genome-wide location of four short-chain acyl histone marks H3K18pr/bu and H4K12pr/bu in treated and untreated colorectal cancer (CRC) and normal cells, as well as in mouse intestines

Identifiers

PMID38410440
PMCPMC10896393
OpenAlexW4391893460

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.