Evidence map›Paper›PMID 38410427›Full record

ArticleResearch square2024

Hybrid Allosteric Modulators of M1 Muscarinic Receptors Enhance Acetylcholine Efficacy and Decrease Locomotor Activity and Turning Behaviors in Zebrafish.

Corey J Widman, Sestina Ventresca, Jillian Dietrich, Gwendolynne Elmslie, Hazel Smith, Gina Kaup, Aaron Wesley, Madeline Doenecke, Frederick E Williams, Isaac T Schiefer and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Corey J WidmanUniversity of Toledo.
Sestina VentrescaUniversity of Toledo.
Jillian DietrichUniversity of Toledo.
Gwendolynne ElmsliePenn State University.
Hazel SmithUniversity of Toledo.
Gina KaupUniversity of Toledo.
Aaron WesleyUniversity of Toledo.
Madeline DoeneckeUniversity of Toledo.
Frederick E WilliamsUniversity of Toledo.
Isaac T SchieferUniversity of Toledo.
John EllisPenn State University.
William S MesserUniversity of Toledo.
University of Toledo · USPennsylvania State University · US

Funding

RESPONSES OF SUBPOPULATIONS OF MUSCARINIC RECEPTORSR01AG005214 · NIA · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI ELLIS, JOHN · 1985 to 2011
$2.3M
Responses of Subpopulations of Muscarinic ReceptorsR56AG005214 · NIA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI ELLIS, JOHN · 2017 to 2017
$618k
NIA NIH HHS R01 AG005214NIA NIH HHS R56 AG005214
6 · The paper itself

Abstract

Allosteric modulation of muscarinic acetylcholine receptors (mAChR) has been identified as a potential strategy for regulating cholinergic signaling in the treatment of various neurological disorders. Most positive allosteric modulators (PAMs) of mAChR enhance agonist affinity and potency, while very few PAMs selectively enhance G-protein coupling efficacy (e.g., amiodarone). The key structural features of amiodarone responsible for enhancement of mAChR efficacy were examined in CHO cells expressing M

Identifiers

PMID38410427
PMCPMC10896388
OpenAlexW4391843361

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.