Evidence map›Paper›PMID 38410284›Full record

ArticleCureus2024

Ring Finger Protein 34 (RNF34) as a Prognostic Biomarker for Clear Cell Renal Cell Carcinoma.

Johannes Stein, Niklas Klümper, Pirmin Zöhrer, Thomas Büttner, Philipp Krausewitz, Manuel Ritter, Glen Kristiansen, Marieta Toma, Jörg Ellinger, Alexander Cox

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Johannes SteinUrology, University Hospital Bonn, University of Bonn, Bonn, DEU.
Niklas KlümperUrology, University Hospital Bonn, University of Bonn, Bonn, DEU.
Pirmin ZöhrerUrology, University Hospital Bonn, University of Bonn, Bonn, DEU.
Thomas BüttnerUrology, University Hospital Bonn, University of Bonn, Bonn, DEU.
Philipp KrausewitzUrology, University Hospital Bonn, University of Bonn, Bonn, DEU.
Manuel RitterUrology, University Hospital Bonn, University of Bonn, Bonn, DEU.
Glen KristiansenPathology, University Hospital Bonn, University of Bonn, Bonn, DEU.
Marieta TomaPathology, University Hospital Bonn, University of Bonn, Bonn, DEU.
Jörg EllingerUrology, University Hospital Bonn, University of Bonn, Bonn, DEU.
Alexander CoxUrology, University Hospital Bonn, University of Bonn, Bonn, DEU.
University Hospital Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRing finger proteins play pivotal roles in diverse cellular processes and are implicated in contribution to cancer. Ring finger protein 34 (RNF34) has antiapoptotic and oncogenic properties. RNF34 is upregulated during carcinogenesis and tumor progression in the colorectal adenoma-carcinoma sequence and was already described to mediate chemoresistance. In clear cell renal cell carcinoma (ccRCC), however, the role and expression patterns of RNF34 are unknown.

methodsFirst, we investigated the association of RNF34 mRNA expression with clinicopathological parameters and survival using data obtained from The Cancer Genome Atlas (TCGA) ccRCC cohort (N = 533). To assess RNA34 protein expression, we performed immunohistochemical (IHC) staining of an established ccRCC cohort (University of Bonn) in a tissue microarray (TMA) format. This validation cohort contains 109 primary ccRCC samples. IHC data were associated with clinicopathological parameters and overall survival (Kaplan-Meier analysis). Adjustment for covariables was done using the Cox regression model.

resultsRNF34 expression is correlated with adverse clinicopathological parameters. Survival analysis revealed an association between RNF34 expression and shortened survival. Cox regression analysis confirmed RNF34 expression as an independent prognostic parameter.

conclusionOur study provides evidence for RNF34 as a prognostic biomarker in ccRCC and points toward a major role of this protein in renal cell carcinoma carcinogenesis.

Indexed as

biomarkerclear cell renal cell carcinomaimmunohistochemistryrenal cell carcinomarnf34tcga

Identifiers

PMID38410284
PMCPMC10895560
OpenAlexW4391278490

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.