Evidence map›Paper›PMID 38410188›Full record

ArticleFrontiers in molecular biosciences2024

Identification of the KIF18A alpha-4 helix as a therapeutic target for chromosomally unstable tumor cells.

Katherine L Schutt, Katelyn A Queen, Kira Fisher, Olivia Budington, Weifeng Mao, Wei Liu, Xiaohui Gu, Yisong Xiao, Fred Aswad, James Joseph and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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  5. Review
  6. Article
  7. Maternal genetic variants in kinesin motor domains prematurely increase egg aneuploidy.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Katherine L Schutt *Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT, United States.
Katelyn A Queen *Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT, United States.
Kira FisherDepartment of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT, United States.
Olivia BudingtonDepartment of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT, United States.
Weifeng MaoApeiron Therapeutics, Shanghai, China.
Wei LiuApeiron Therapeutics, Shanghai, China.
Xiaohui GuApeiron Therapeutics, Shanghai, China.
Yisong XiaoApeiron Therapeutics, Shanghai, China.
Fred AswadApeiron Therapeutics, Burlingame, CA, United States.
James JosephApeiron Therapeutics, Burlingame, CA, United States.
Jason StumpffDepartment of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT, United States.
University of Vermont · USApeiron Biologics (Austria) · AT

Funding

Mechanisms of microtubule motors and chromosome segregationR35GM144133 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI JASON K STUMPFF · 2022 to 2026
$2.4M
Tuning Mitotic Kinesins Through Motor Domain Post Translational ModificationsR01GM130556 · NIGMS · MAYO CLINIC JACKSONVILLE · PI GROSS, STEVEN P, MURETTA, JOSEPH M. · 2019 to 2022
$2.4M
NIGMS NIH HHS R01 GM130556NIGMS NIH HHS R35 GM144133
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

chromosome instabilityKIF18Akinesinmitosissmall-molecule inhibitorspindle

Identifiers

PMID38410188
PMCPMC10896213
OpenAlexW4391755258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.