Evidence map›Paper›PMID 38410026›Full record

ArticleNanoscale2024

Imidazolium-based zwitterionic liquid-modified PEG-PLGA nanoparticles as a potential intravenous drug delivery carrier.

Gaya S Dasanayake, Christine M Hamadani, Gagandeep Singh, Sandeep Kumar Misra, Priyavrat Vashisth, Joshua S Sharp, Laxmi Adhikari, Gary A Baker, Eden E L Tanner

Open access · bronzeAbstract read
In one paragraph

Article in Nanoscale, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Gaya S DasanayakeDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS 38677, USA. eetanner@olemiss.edu.ORCID http://orcid.org/0000-0002-2399-2458
Christine M HamadaniDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS 38677, USA. eetanner@olemiss.edu.ORCID http://orcid.org/0000-0003-4774-6777
Gagandeep SinghDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS 38677, USA. eetanner@olemiss.edu.
Sandeep Kumar MisraDepartment of BioMolecular Sciences, University of Mississippi, University, MS 38677, USA.
Priyavrat VashisthDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS 38677, USA. eetanner@olemiss.edu.
Joshua S SharpDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS 38677, USA. eetanner@olemiss.edu.ORCID http://orcid.org/0000-0002-0115-0276
Laxmi AdhikariDepartment of Chemistry, University of Missouri, Columbia, MO, 65211, USA.
Gary A BakerDepartment of Chemistry, University of Missouri, Columbia, MO, 65211, USA.ORCID http://orcid.org/0000-0002-3052-7730
Eden E L TannerDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS 38677, USA. eetanner@olemiss.edu.ORCID http://orcid.org/0000-0002-7919-2249
University of Mississippi · USUniversity of Missouri · US

Funding

Tracking Glycosylation State with Fluorinated Glycosides ProbesP20GM130460 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI Joshua S Sharp · 2020 to 2026
$17.9M
Laser spectroscopic instrumentation for isotopic sensing of biogenic Nitric OxideR21GM103460 · NIGMS · PRINCETON UNIVERSITY · PI WYSOCKI, GERARD · 2012 to 2012
$190k
NIGMS NIH HHS P20 GM130460NIGMS NIH HHS R21 GM103460
6 · The paper itself

Abstract

Zwitterionic-based systems offer promise as next-generation drug delivery biomaterials capable of enhancing nanoparticle (NP) stimuli-responsiveness, biorecognition, and biocompatibility. Further, imidazole-functionalized amphiphilic zwitterions are able to readily bind to various biological macromolecules, enabling antifouling properties for enhanced drug delivery efficacy and bio-targeting. Herein, we describe structurally tuned zwitterionic imidazole-based ionic liquid (ZIL)-coated PEG-PLGA nanoparticles made with sonicated nanoprecipitation. Upon ZIL surface modification, the hydrodynamic radius increased by nearly 20 nm, and the surface charge significantly shifted closer to neutral.

Indexed as

NanoparticlesPolyestersTandem Mass SpectrometryAnimalsChromatography, LiquidDrug CarriersDrug Delivery SystemsHumansImidazolesMicePolyethylene GlycolsDrug CarriersImidazolesPolyesterspolyethylene glycol-poly(lactide-co-glycolide)Polyethylene Glycols

Identifiers

PMID38410026
PMCPMC11476077
OpenAlexW4392257059

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.