ArticleBrain and behavior2024
Sex and race differences in the association of albumin with cognitive function in older adults.
Article in Brain and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- The association between atherogenic index of plasma and postoperative delirium in cardiac surgery patients: an analysis of the MIMIC-IV database.Perioperative medicine (London, England) · 2026Article
- Article
- Impact of ambient temperature on postoperative cognitive dysfunction in elderly patients surgery: A seasonal comparison in tropical regions.World journal of psychiatry · 2025Article
- Observational
- Interaction and overall effects of underweight, low muscle mass, malnutrition, and inflammation on early-onset mild cognitive impairment in type 2 diabetes.Frontiers in aging neuroscience · 2025Article
- Relationship of Neutrophil Percentage-to-Albumin Ratio With Stroke: Evidence From NHANES 1999-2020.Brain and behavior · 2024Article
- Mediation Effect of Oxidative Stress on Association Between Selenium Intake and Cognition in American Adults.Nutrients · 2024Article
- Sex and race differences in the association of albumin with cognitive function in older adults.Brain and behavior · 2024Article
- Association between the geriatric nutritional risk index and cognitive functions in older adults: a cross-sectional study from National Health and Nutrition Examination Survey.Frontiers in nutrition · 2024Article
- The mediating role of white matter hyperintensity in the association between malnutrition and cognitive impairment in patients with cerebral small vessel disease.Frontiers in neurologyArticle
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Authors and funding
7 authors.
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Abstract
backgroundWith the increasing aging population, dementia has become a significant socioeconomic burden. However, the effects of albumin on delayed recall (DR) impairment remain unclear, and there are limited reports on sex and race differences in this relationship. This study aimed to investigate the association between albumin levels and DR impairment in older adults.
methodsA total of 1507 normal cognitive function and 553 DR impairment from the National Health and Nutrition Examination Survey (NHANES) 2011-2014 were included in this cross-sectional analysis. Participants aged 60 years and above were assessed using the Consortium to Establish a Registry for Alzheimer's Disease DR (CERAD-DR) test to evaluate cognitive function. Participants were categorized into DR impairment and normal cognitive function groups according to their CERAD-DR scores. Logistic regression analyses, generalized additive models, and fitted smoothing curves were utilized for data analysis.
resultsAfter adjusting for potential confounders, a negative association was found between albumin levels and cognitive function (odds ratio [OR] = 0.60, 95% confidence interval [CI] 0.41-0.87). Subgroup analysis stratified by sex, race/ethnicity, and age revealed that the negative association remained significant in men (OR = 0.53, 95%CI 032-0.87), Blacks (OR = 0.35, 95%CI 0.17-0.74), and the age group of 60-70 years (OR = 0.48, 95%CI 0.28-0.81). However, no significant association was observed in women (OR = 0.72, 95%CI 0.41-1.28), whites (OR = 0.58, 95%CI 0.31-1.07), or Mexican Americans (OR = 1.11, 95%CI 0.35-3.46), as well as the age group of 71-80 years (OR = 0.62, 95%CI 0.37-1.03).
conclusionsOur study suggests that elevated albumin levels are associated with a decreased incidence of cognitive function impairment, particularly in older men and Blacks. This finding indicates that maintaining high levels of albumin may be beneficial for cognitive function in older adults.
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