ArticleEuropean stroke journal2024
Incidence and clinical outcomes of perforations during mechanical thrombectomy for medium vessel occlusion in acute ischemic stroke: A retrospective, multicenter, and multinational study.
Open access · bronzeAbstract readMulticenter Study
In one paragraph
Article in European stroke journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
0numbers the graph read from it
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29citing papers in PubMed
17.8field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- Intra-Arterial Thrombolytic vs. Mechanical Thrombectomy in Distal Medium Middle Cerebral Artery Acute Ischemic Stroke: A Preliminary Multinational Multicenter Propensity Score-Matched Study.Clinical neuroradiology · 2026Observational
- Endovascular Thrombectomy in Medium and Distal Vessel Occlusions: A Focused Guideline From the Society of Vascular and Interventional Neurology Guidelines and Practice Standards Committee.Stroke (Hoboken, N.J.) · 2026Review
- Sex-Related Differences in Outcomes of Endovascular Treatment of Distal Medium Vessel Occlusion Strokes.Clinical neuroradiology · 2026Article
- Utility of Non-Contrast CT and MRA Fusion Images for Depicting Occluded Vessels in Mechanical Thrombectomy.Journal of neuroendovascular therapy · 2026Article
- Baseline prolonged venous transit on CT perfusion predicts the post-treatment Brush Sign after successful reperfusion in acute ischemic stroke patients.Frontiers in neurology · 2026Article
- Clinical outcomes of patients with unsuccessful mechanical thrombectomy versus best medical management of medium vessel occlusion stroke in the middle cerebral artery territory.Journal of neurointerventional surgery · 2025Article
- Visualization of Distal Vessels during Mechanical Thrombectomy using Aortic Cone-beam Computed Tomography.Neurologia medico-chirurgica · 2025Article
- Hypoperfusion intensity ratio is associated with follow-up infarct volume in medium vessel occlusions: A multicenter multinational study.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Incidence and potential predictors of first pass effect within 30 min of groin puncture: An exploratory single-center study.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Interobserver and Intraobserver Variability in the Assessment of Prolonged Venous Transit in Anterior Circulation Large-Vessel Occlusion Ischemic Stroke.AJNR. American journal of neuroradiology · 2025Article
- Entrapment of microguidewire into perforator during endovascular treatment: Case report and management strategy.The Journal of international medical research · 2025Article
- Baseline predictors of poor clinical outcome despite recanalization of distal middle cerebral artery occlusions.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Initial experience using the Passerelle 21 microcatheter for the Red 43 reperfusion catheter navigation in distal medium vessel occlusion: A technical case report.Radiology case reports · 2025Article
- Efficacy and safety of mechanical thrombectomy in distal medium middle cerebral artery occlusion ischemic stroke patients on low-dose aspirin.International journal of stroke : official journal of the International Stroke Society · 2025Article
- Treatment outcomes of successful M1 versus M2 thrombectomy for low-ASPECTS stroke patients.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Endovascular therapy versus medical management in isolated anterior cerebral artery acute ischemic stroke: a multinational multicenter propensity score-weighted study.Journal of neurointerventional surgery · 2025Article
- Predictive value of follow-up infarct volume on functional outcomes in middle cerebral artery M2 segment vessel occlusion stroke treated with mechanical thrombectomy.European stroke journal · 2025Article
- Endovascular therapy versus medical management in isolated posterior cerebral artery acute ischemic stroke: A multinational multicenter propensity score-weighted study.European stroke journal · 2025Article
- Association of Pretreatment Perfusion Imaging Parameters with 90-Day Excellent Functional Outcomes in Anterior Circulation Distal Medium Vessel Occlusion Stroke.AJNR. American journal of neuroradiology · 2025Article
- Prolonged venous transit is associated with lower odds of excellent recovery after reperfusion in anterior large-vessel occlusion stroke.European journal of neurology · 2025Article
Corrections and comments
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Authors and funding
94 authors at 20 institutions in 12 countries.
Adam A DmytriwNeuroendovascular Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Basel MusmarDepartment of Neurosurgery and Interventional Neuroradiology, Louisiana State University, Shreveport, LA, USA.ORCID 0009-0000-4910-6090
Hamza SalimDepartment of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA.ORCID 0000-0002-5208-8425
Sherief GhozyDepartment of Neurological Surgery and Radiology, Mayo Clinic, Rochester, MN, USA.
James E SieglerCooper Neurological Institute, Cooper University Hospital, Cooper Medical School of Rowen University, Camden, NJ, USA.
Hassan KobeissiDepartment of Neurological Surgery and Radiology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-7446-624X
Hamza ShaikhCooper Neurological Institute, Cooper University Hospital, Cooper Medical School of Rowen University, Camden, NJ, USA.
Jane KhalifeCooper Neurological Institute, Cooper University Hospital, Cooper Medical School of Rowen University, Camden, NJ, USA.
Mohamad AbdalkaderDepartments of Radiology and Neurology, Boston Medical Center, Boston, MA, USA.
Piers KleinDepartments of Radiology and Neurology, Boston Medical Center, Boston, MA, USA.ORCID 0000-0001-7468-137X
Thanh N NguyenDepartments of Radiology and Neurology, Boston Medical Center, Boston, MA, USA.ORCID 0000-0002-2810-1685
Jeremy J HeitDepartment of Interventional Neuroradiology, Stanford Medical Center, Palo Alto, CA, USA.
Robert W RegenhardtNeuroendovascular Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-2958-3484
Nicole M CancelliereNeurovascular Centre, Divisions of Therapeutic Neuroradiology and Neurosurgery, St. Michael's Hospital, University of Toronto, ON, Canada.
Joshua D BernstockDepartment of Neurosurgery, Brigham and Women's Hospital, Boston, MA, USA.
Kareem El NaamaniDepartment of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, USA.
Abdelaziz AmllayDepartment of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, USA.
Lukas MeyerDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Anne DusartDepartment of Neurology, Hôpital Civil Marie Curie, Charleroi, Belgium.
Flavio BellanteDepartment of Neurology, Hôpital Civil Marie Curie, Charleroi, Belgium.ORCID 0000-0002-8718-9250
Géraud ForestierUniversity Hospital of Limoges, Neuroradiology Department, Dupuytren, Université de Limoges, XLIM CNRS, UMR 7252, Limoges, France.ORCID 0000-0003-4797-9693
Aymeric RouchaudUniversity Hospital of Limoges, Neuroradiology Department, Dupuytren, Université de Limoges, XLIM CNRS, UMR 7252, Limoges, France.
Suzana SalemeUniversity Hospital of Limoges, Neuroradiology Department, Dupuytren, Université de Limoges, XLIM CNRS, UMR 7252, Limoges, France.
Charbel MounayerUniversity Hospital of Limoges, Neuroradiology Department, Dupuytren, Université de Limoges, XLIM CNRS, UMR 7252, Limoges, France.
Jens FiehlerDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Anna Luisa KühnDivision of Neurointerventional Radiology, Department of Radiology, University of Massachusetts Medical Center, Worcester, MA, USA.
Ajit S PuriDivision of Neurointerventional Radiology, Department of Radiology, University of Massachusetts Medical Center, Worcester, MA, USA.
Christian DyzmannNeuroradiology Department, Sana Kliniken, Lübeck GmbH, Lübeck, Germany.
Peter T KanDepartment of Neurosurgery, University of Texas Medical Branch, Galveston, TX, USA.
Marco ColasurdoDepartment of Neurosurgery, University of Texas Medical Branch, Galveston, TX, USA.
Gaultier MarnatInterventional Neuroradiology Department, Bordeaux University Hospital, Bordeaux, France.ORCID 0000-0002-7611-7753
Jérôme BergeInterventional Neuroradiology Department, Bordeaux University Hospital, Bordeaux, France.
Xavier BarreauInterventional Neuroradiology Department, Bordeaux University Hospital, Bordeaux, France.
Igor SibonNeurology Department, Bordeaux University Hospital, Bordeaux, France.
Simona NedelcuDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Nils HenningerDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Thomas R MarottaNeurovascular Centre, Divisions of Therapeutic Neuroradiology and Neurosurgery, St. Michael's Hospital, University of Toronto, ON, Canada.
Christopher J StapletonNeuroendovascular Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
James D RabinovNeuroendovascular Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Takahiro OtaDepartment of Neurosurgery, Tokyo Metropolitan Tama Medical Center, Fuchu, Japan.ORCID 0000-0002-5108-6719
Shogo DofukuDepartment of Neurosurgery, Tokyo Metropolitan Tama Medical Center, Fuchu, Japan.ORCID 0000-0002-3064-8858
Leonard Ll YeoDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-4249-0402
Benjamin Yq TanDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Anil GopinathanDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Juan Carlos Martinez-GutierrezDepartment of Neurology, UTHealth McGovern Medical School, Houston, TX, USA.
Sergio Salazar-MarioniDepartment of Neurology, UTHealth McGovern Medical School, Houston, TX, USA.ORCID 0000-0002-2722-7542
Sunil ShethInterventistica Neurovascolare, Ospedale Careggi di Firenze, Florence, Italy.
Leonardo RenieriInterventistica Neurovascolare, Ospedale Careggi di Firenze, Florence, Italy.
Carolina CapirossiInterventistica Neurovascolare, Ospedale Careggi di Firenze, Florence, Italy.
Ashkan MowlaDivision of Stroke and Endovascular Neurosurgery, Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Lina ChervakDepartment of Neurology and Radiology, University of Cincinnati, Cincinnati, OH, USA.
Achala VagalDepartment of Neurology and Radiology, University of Cincinnati, Cincinnati, OH, USA.
Nimer AdeebDepartment of Neurosurgery and Interventional Neuroradiology, Louisiana State University, Shreveport, LA, USA.
Hugo H Cuellar-SaenzDepartment of Neurosurgery and Interventional Neuroradiology, Louisiana State University, Shreveport, LA, USA.
Stavropoula I TjoumakarisDepartment of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, USA.
Pascal JabbourDepartment of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0002-8965-2413
Priyank KhandelwalDepartment of Endovascular Neurosurgery and Neuroradiology, Rutgers New Jersey Medical School, Newark, NJ, USA.
Arundhati BiswasDepartment of Neurosurgery, Westchester Medical Center at New York Medical College, Valhalla, NY, USA.
Frédéric ClarençonDepartment of Neuroradiology, Pitié-Salpêtrière Hospital, Paris, France.
Mahmoud ElhoranyDepartment of Neuroradiology, Pitié-Salpêtrière Hospital, Paris, France.
Kevin PrematDepartment of Neuroradiology, Pitié-Salpêtrière Hospital, Paris, France.
Iacopo ValenteUOSA Neuroradiologia Interventistica, Fondazione Policlinico Universitario A. Gemelli IRCCS Roma, Florence, Italy.
Alessandro PedicelliUOSA Neuroradiologia Interventistica, Fondazione Policlinico Universitario A. Gemelli IRCCS Roma, Florence, Italy.
João Pedro FilipeDepartment of Diagnostic and Interventional Neuroradiology, Centro Hospitalar Universitário do Porto, Porto, Portugal.
Ricardo VarelaDepartment of Diagnostic and Interventional Neuroradiology, Centro Hospitalar Universitário do Porto, Porto, Portugal.
Miguel Quintero-ConsuegraDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Nestor R GonzalezDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0002-8277-6317
Markus A MöhlenbruchSektion Vaskuläre und Interventionelle Neuroradiologie, Universitätsklinikum Heidelberg, Heidelberg, Germany.ORCID 0000-0002-5075-704X
Jessica JesserSektion Vaskuläre und Interventionelle Neuroradiologie, Universitätsklinikum Heidelberg, Heidelberg, Germany.ORCID 0000-0002-1236-8828
Vincent CostalatDepartment of Neuroradiology, Gui de Chauliac Hospital, Montpellier University Medical Center, Montpellier, France.
Adrien Ter SchiphorstDepartment of Neurology, Gui de Chauliac Hospital, Montpellier University Medical Center, Montpellier, France.
Vivek YedavalliINSERM U1254, IADI, Université de Lorraine, Vandoeuvre-les-Nancy, France.
Pablo HarkerDepartment of Neurology, University of Cincinnati Medical Center, Cincinnati, OH, USA.
Yasmin AzizDepartment of Neurology, University of Cincinnati Medical Center, Cincinnati, OH, USA.ORCID 0000-0002-3515-4005
Benjamin GoryDepartment of Interventional Neuroradiology, Nancy University Hospital, Nancy, France.
Christian Paul StrackeDepartment of Radiology, Interventional Neuroradiology Section, University Medical Center Münster, Münster, Germany.
Constantin HeckerDepartment of Neurology and Neurosurgery, Christian Doppler Clinic, Paracelsus Medical University, Salzburg, Austria.
Ramanathan KadirvelDepartment of Neurological Surgery and Radiology, Mayo Clinic, Rochester, MN, USA.
Monika Killer-OberpfalzerDepartment of Neurology and Neurosurgery, Christian Doppler Clinic, Paracelsus Medical University, Salzburg, Austria.
Christoph J GriessenauerDepartment of Neurology and Neurosurgery, Christian Doppler Clinic, Paracelsus Medical University, Salzburg, Austria.
Ajith J ThomasCooper Neurological Institute, Cooper University Hospital, Cooper Medical School of Rowen University, Camden, NJ, USA.
Cheng-Yang HsiehNeurology Department, Sin-Lau Hospital, Tainan, Taiwan.
David S LiebeskindUCLA Stroke Center and Department of Neurology Department, University of California, Los Angeles, Los Angeles, CA USA.
Răzvan Alexandru RaduDepartment of Neuroradiology, Gui de Chauliac Hospital, Montpellier University Medical Center, Montpellier, France.ORCID 0000-0001-6375-8466
Andrea M AlexandreUOSA Neuroradiologia Interventistica, Fondazione Policlinico Universitario A. Gemelli IRCCS Roma, Florence, Italy.
Illario TancrediDepartment of Radiology, Hôpital Civil Marie Curie, Charleroi, Belgium.
Tobias D FaizyDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-1631-2020
Robert FahedDivision of Neurology, Department of Medicine, The Ottawa Hospital, Ottawa Hospital Research Institute and University of Ottawa, Ottawa, ON, Canada.ORCID 0000-0002-1887-5097
Charlotte WeylandSektion Vaskuläre und Interventionelle Neuroradiologie, Universitätsklinikum Heidelberg, Heidelberg, Germany.
Boris LubiczDepartment of Diagnostic and Interventional Neuroradiology, Erasme University Hospital, Brussels, Belgium.
Aman B PatelNeuroendovascular Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Vitor Mendes PereiraNeurovascular Centre, Divisions of Therapeutic Neuroradiology and Neurosurgery, St. Michael's Hospital, University of Toronto, ON, Canada.
Adrien GuenegoDepartment of Diagnostic and Interventional Neuroradiology, Erasme University Hospital, Brussels, Belgium.
MAD-MT Consortium
Centre National de la Recherche Scientifique · FRCooper University Hospital · USHarvard University · USSt. Michael's Hospital · CAThomas Jefferson University · USUniversité de Bordeaux · FRUniversity of Cincinnati · USAgostino Gemelli University Polyclinic · ITAzienda Ospedaliero-Universitaria Careggi · ITBoston Medical Center · USHeidelberg University · DEHôpital Civil de Charleroi · BELouisiana State University in Shreveport · USMayo Clinic · USNational University of Singapore · SGParacelsus Medical University · ATUniversität Hamburg · DEUniversité de Montpellier · FRUniversité Sorbonne Nouvelle · FRUniversity of Massachusetts Chan Medical School · US
Funding
Role of Sarm1 in TBI-accentuated C9orf72 Frontotemporal DementiaR21NS131756 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HENNINGER, NILS · 2023 to 2024
$461kNINDS NIH HHS R21 NS131756
Abstract
backgroundMechanical thrombectomy (MT) has revolutionized the treatment of acute ischemic stroke (AIS) due to large vessel occlusion (LVO), but its efficacy and safety in medium vessel occlusion (MeVO) remain less explored. This multicenter, retrospective study aims to investigate the incidence and clinical outcomes of vessel perforations (confirmed by extravasation during an angiographic series) during MT for AIS caused by MeVO.
methodsData were collected from 37 academic centers across North America, Asia, and Europe between September 2017 and July 2021. A total of 1373 AIS patients with MeVO underwent MT. Baseline characteristics, procedural details, and clinical outcomes were analyzed.
resultsThe incidence of vessel perforation was 4.8% (66/1373). Notably, our analysis indicates variations in perforation rates across different arterial segments: 8.9% in M3 segments, 4.3% in M2 segments, and 8.3% in A2 segments (
conclusionThis study reveals that while the occurrence of vessel perforation in MT for AIS due to MeVO is relatively rare, it is associated with poor functional outcomes and higher mortality. The findings highlight the need for increased caution and specialized training in performing MT for MeVO. Further prospective research is required for risk mitigation strategies.
Indexed as
Ischemic StrokeThrombectomyAgedAged, 80 and overFemaleHumansIncidenceMaleMiddle AgedRetrospective StudiesTreatment OutcomeAISmechanical thrombectomyMeVoMTperforationStroke
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