Evidence map›Paper›PMID 38409761›Full record

SynthesisSingapore medical journal2026

Migraine and atrial fibrillation: a systematic review and meta-analysis.

Camelia Qi En Lim, Yao Neng Teo, Tony Yi-Wei Li, Yao Hao Teo, Nicholas Li-Xun Syn, Aloysius Sheng-Ting Leow, Jamie Sin-Ying Ho, Toon Wei Lim, Swee-Chong Seow, Mark Yan Yee Chan and 8 more

Open access · diamondAbstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Singapore medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 3 countries.

Camelia Qi En LimSchool of Medicine, Monash University, Melbourne, Australia.
Yao Neng TeoDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Tony Yi-Wei LiDepartment of Cardiology, National University Heart Centre Singapore, National University Health System, Singapore.
Yao Hao TeoDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Nicholas Li-Xun SynDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Aloysius Sheng-Ting LeowDepartment of Cardiology, National University Heart Centre Singapore, National University Health System, Singapore.
Jamie Sin-Ying HoAcademic Foundation Year Programme, Royal Free Hospital University Trust, London, United Kingdom.
Toon Wei LimDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Swee-Chong SeowDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Mark Yan Yee ChanDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Raymond Ching Chiew WongDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Ping ChaiDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Amanda Chee Yun ChanDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Vijay Kumar SharmaDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Benjamin Yong-Qiang TanDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Leonard Leong Litt YeoDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Jonathan Jia Yuan OngDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Ching-Hui SiaDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
National University of Singapore · SGNational University Health System · SGNational University Heart Centre Singapore · SGMonash University · AUUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with migraines, particularly those with auras, may present with stroke. Atrial fibrillation is a known risk factor for stroke. With common pathophysiological factors between migraines and atrial fibrillation, we aimed to clarify the association between migraine and atrial fibrillation in this systematic review and meta-analysis.

methodsA literature search was conducted in EMBASE, PubMed, Scopus and Cochrane electronic bibliographic databases from inception to 5 September 2022 with the following inclusion criteria: (a) cohort or cross-sectional studies; (b) studies that included only patients aged ≥18 years; and (c) studies that examined the association between atrial fibrillation and migraines. Exclusion criteria were case-control studies and the studies that included patients with previous diagnosis of atrial fibrillation or nonmigrainous headache. The Newcastle-Ottawa Scale was used to assess the quality of studies.

resultsSix studies were included, demonstrating a pooled prevalence of atrial fibrillation of 1.61% (95% confidence interval [CI] 0.51, 3.29) in migraine with aura and 1.32% (95% CI 0.17, 3.41) in migraine without aura. The overall prevalence of atrial fibrillation in migraine was 1.39% (95% CI 0.24, 3.46).

conclusionIn this systematic review and meta-analysis, the overall prevalence of atrial fibrillation in patients with migraine was low. Further studies are needed to clarify this relationship.

Indexed as

Atrial FibrillationMigraine DisordersCross-Sectional StudiesHumansPrevalenceRisk FactorsStrokeAtrial fibrillationmigrainestroke

Identifiers

PMID38409761
PMCPMC13405447
OpenAlexW4392195042

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.