Evidence map›Paper›PMID 38409711›Full record

ArticleCurrent Alzheimer research2024

The Association of Allergy-Related and Non-Allergy-Related Olfactory Impairment with Cognitive Function in Older Adults: Two Cross- Sectional Studies.

Hui Chen, Yihong Ding, Liyan Huang, Wansi Zhong, Xiaojun Lin, Baoyue Zhang, Yan Zheng, Xin Xu, Min Lou, Changzheng Yuan

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Article in Current Alzheimer research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Hui ChenSchool of Public Health, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yihong DingSchool of Public Health, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Liyan HuangSchool of Public Health, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Wansi ZhongDepartment of Neurology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xiaojun LinSchool of Public Health, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Baoyue ZhangSchool of Public Health, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yan ZhengHuman Phenome Institute, School of Life Sciences, Fudan University, Shanghai, China.
Xin XuSchool of Public Health, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Min LouDepartment of Neurology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Changzheng YuanSchool of Public Health, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Second Affiliated Hospital of Zhejiang University · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEvidence on the association of Olfactory Impairment (OI) with age-related cognitive decline is inconclusive, and the potential influence of allergy remains unclear.

objectiveWe aimed to evaluate the cross-sectional associations of allergy-related and non-allergy- related OI to cognitive function.

methodsWe included 2,499 participants from the Health and Retirement Study (HRS)-Harmonized Cognitive Assessment Protocol (HCAP) sub-study and 1,086 participants from the English Longitudinal Study of Ageing (ELSA)-HCAP. The Olfactory Function Field Exam (OFFE) using Sniffin' Stick odor pens was used to objectively assess olfactory function and an olfactory score <6/11 indicated OI. Mini-Mental Status Examination (MMSE) was used to assess global cognitive function and define cognitive impairment (<24/30). A neuropsychologic battery was used to assess five cognitive domains.

resultsCompared to non-OI participants, individuals with OI had lower MMSE z-score [β

conclusionOI, particularly non-allergy-related OI, was related to poorer cognitive function in older adults. Although the current cross-sectional study is subject to several limitations, such as reverse causality and residual confounding, the findings will provide insights into the OI-cognition association and enlighten future attention to non-allergy-related OI for the prevention of potential cognitive impairment.

Indexed as

Cognitive DysfunctionHypersensitivityOlfaction DisordersAgedAged, 80 and overAgingCognitionCross-Sectional StudiesFemaleHumansLongitudinal StudiesMaleMental Status and Dementia TestsMiddle AgedNeuropsychological Testsallergic statuscognitive domainscognitive impairmentcrosssectional studies.Global cognitive functionolfactory impairment

Identifiers

PMID38409711
OpenAlexW4392195472

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.