Evidence map›Paper›PMID 38409448›Full record

ArticleExperimental & molecular medicine2024

NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells.

Hye Yeon Choi, Yicheng Zhu, Xuyao Zhao, Simran Mehta, Juan Carlos Hernandez, Jae-Jin Lee, Yi Kou, Risa Machida, Mauro Giacca, Giannino Del Sal and 6 more

RetractedErratum issuedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental & molecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Hye Yeon Choi *Departments of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA, USA.
Yicheng Zhu *Departments of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-0039-9210
Xuyao ZhaoDepartments of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA, USA.
Simran MehtaDepartments of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA, USA.
Juan Carlos HernandezDepartments of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA, USA.
Jae-Jin LeeDepartments of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-8317-437X
Yi KouViterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
Risa MachidaDepartments of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA, USA.
Mauro GiaccaInternational Centre for Genetic Engineering and Biotechnology, Trieste, Italy.
Giannino Del SalDepartment of Life Sciences, University of Trieste, 34127, Trieste, Italy.
Ratna RaySaint Louis University, School of Medicine, St Louis, MO, USA.
Hyungjin EohDepartments of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-8774-6400
Stanley M TaharaDepartments of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-5097-0927
Lin ChenViterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-4798-6199
Hidekazu TsukamotoDepartment of Pathology, University of Southern California, Los Angeles, CA, USA.
Keigo MachidaDepartments of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA, USA. keigo.machida@med.usc.edu.ORCID http://orcid.org/0000-0002-9721-8553
University of Southern California · USInternational Centre for Genetic Engineering and Biotechnology · ITSaint Louis University · USUniversity of Trieste · IT

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MYLES G COCKBURN · 1985 to 2026
$181.4M
The Southernearch Center for ALPD and CirrhosisP50AA011999 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ANNA S. GUKOVSKAYA · 1999 to 2026
$45.8M
USC RESEARCH CENTER FOR LIVER DISEASES: PILOT PROGRAMSP30DK048522 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI OOKHTENS, MURAD · 1995 to 2020
$21.8M
NON-PARENCHYMAL LIVER CELL CORER24AA012885 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TSUKAMOTO, HIDEKAZU · 2001 to 2025
$8.1M
NANOG-positive cancer stem cells in liver oncogenesis induced by alcohol and HCVR01AA025204 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MACHIDA, KEIGO · 2017 to 2021
$1.9M
Nanog-positive cancer stem cells in and liver oncogenesis by alcohol and HCVR01AA018857 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MACHIDA, KEIGO · 2009 to 2013
$1.8M
LncRNA with MSI2 and super-enhancer in liver cancer stem cells induced by alcoholR21AA025470 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MACHIDA, KEIGO · 2018 to 2019
$444k
NCI NIH HHS P30 CA014089NIAAA NIH HHS P50 AA011999NIAAA NIH HHS R01 AA018857NIAAA NIH HHS R01 AA025204NIAAA NIH HHS R21 AA025470NIAAA NIH HHS R24 AA012885NIDDK NIH HHS P30 DK048522
6 · The paper itself

Abstract

The P53-destabilizing TBC1D15-NOTCH protein interaction promotes self-renewal of tumor-initiating stem-like cells (TICs); however, the mechanisms governing the regulation of this pathway have not been fully elucidated. Here, we show that TBC1D15 stabilizes NOTCH and c-JUN through blockade of E3 ligase and CDK8 recruitment to phosphodegron sequences. Chromatin immunoprecipitation (ChIP-seq) analysis was performed to determine whether TBC1D15-dependent NOTCH1 binding occurs in TICs or non-TICs. The TIC population was isolated to evaluate TBC1D15-dependent NOTCH1 stabilization mechanisms. The tumor incidence in hepatocyte-specific triple knockout (Alb::CreERT2;Tbc1d15

Indexed as

MitochondriaUbiquitin-Protein LigasesAnimalsChromatin ImmunoprecipitationCyclin-Dependent Kinase 8Cyclin-Dependent KinasesDisease Models, AnimalGTPase-Activating ProteinsHumansMembrane ProteinsMiceMitochondrial MembranesMitochondrial ProteinsPhosphorylationCDK19 protein, humanCDK8 protein, humanCyclin-Dependent Kinase 8Cyclin-Dependent KinasesFIS1 protein, humanFIS1 protein, mouseGTPase-Activating ProteinsMembrane ProteinsMitochondrial ProteinsTBC1D15 protein, humanUbiquitin-Protein Ligases

Identifiers

PMID38409448
PMCPMC10907578
OpenAlexW4392194624

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.