Evidence map›Paper›PMID 38409436›Full record

Trial reportEuropean journal of nutrition2024

Is high salt intake inducing obesity via production of cortisol? A novel working hypothesis and pilot study.

Anthony Nowell, Susan J Torres, Sarah J Hall, Michelle A Keske, David J Torpy, Lewan Parker, Andrew C Betik, Anne I Turner

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Anthony NowellInstitute for Physical Activity and Nutrition, Deakin University, Geelong, VIC, Australia.
Susan J TorresInstitute for Physical Activity and Nutrition, Deakin University, Geelong, VIC, Australia.ORCID http://orcid.org/0000-0002-2599-1934
Sarah J HallInstitute for Physical Activity and Nutrition, Deakin University, Geelong, VIC, Australia.ORCID http://orcid.org/0000-0002-8723-4787
Michelle A KeskeInstitute for Physical Activity and Nutrition, Deakin University, Geelong, VIC, Australia.ORCID http://orcid.org/0000-0003-4214-7628
David J TorpyEndocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, SA, Australia.ORCID http://orcid.org/0000-0002-5069-0981
Lewan ParkerInstitute for Physical Activity and Nutrition, Deakin University, Geelong, VIC, Australia.ORCID http://orcid.org/0000-0002-5372-1851
Andrew C BetikInstitute for Physical Activity and Nutrition, Deakin University, Geelong, VIC, Australia.ORCID http://orcid.org/0000-0001-8294-9719
Anne I TurnerInstitute for Physical Activity and Nutrition, Deakin University, Geelong, VIC, Australia. anne.turner@deakin.edu.au.ORCID http://orcid.org/0000-0002-0682-2860
Deakin University · AURoyal Adelaide Hospital · AU

Funding

National Health and Medical Research Council and National Heart Foundation Early Career Fellowship GNT1157930
6 · The paper itself

Abstract

purposeEvidence is growing that high salt intake is an independent risk factor for obesity, but the mechanisms are unknown. Our novel working hypothesis is that high salt intake drives cortisol production, which in turn, drives obesity. The current study aimed to demonstrate an acute cortisol response following a single high salt meal.

methodsEight participants (age 30.5 ± 9.8 years [mean ± SD], 50% female), consumed high salt (3.82 g; 1529 mg sodium) and low salt (0.02 g; 9 mg sodium) meals in a randomized cross-over design.

resultsUrinary and salivary cortisol and plasma adrenocorticotropic hormone (ACTH) demonstrated order effects. When high salt was given second, there was a peak above baseline for urinary cortisol (26.3%), salivary cortisol (9.4%) and plasma ACTH (4.1%) followed by a significant decline in each hormone (treatment*time, F[9, 18] = 2.641, p = 0.038, partial η

conclusionThese intriguing findings provide partial support for our hypothesis and support a need for further research to elucidate the role of high salt intake in cortisol production and, in turn, in the aetiology of obesity. TRIAL REGISTRATION NUMBER: ACTRN12623000490673; date of registration 12/05/2023; retrospectively registered.

Indexed as

Cross-Over StudiesHydrocortisoneObesitySodium Chloride, DietaryAdrenocorticotropic HormoneAdultFemaleHumansMalePilot ProjectsSalivaYoung AdultAdrenocorticotropic HormoneHydrocortisoneSodium Chloride, DietaryACTHCortisolObesitySaltSalt intakeSodium

Identifiers

PMID38409436
PMCPMC11139711
OpenAlexW4392169512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.