ArticleNature communications2024
Intestinal stroma guides monocyte differentiation to macrophages through GM-CSF.
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Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Trial
- Cellular crosstalk of fibroblast-myofibroblast transition in intestinal homeostasis and disease.Biomarker research · 2026Review
- Depletion and replacement of tissue-resident macrophages in mice with germ-line deletion of a conserved enhancer in the Csf1r locus.Development (Cambridge, England) · 2026Article
- Review
- Crosstalk between macrophages and fibroblasts contributes to inflammation and damage in giant cell arteritis.Rheumatology (Oxford, England) · 2026Article
- RNA modifications in intestinal macrophages: Implications for gut immunity and inflammation.Genes & diseases · 2026Review
- Macrophages in Ulcerative Colitis: Immunomodulatory Roles, Phenotypic Switching, and Therapeutic Targeting.Journal of innate immunity · 2026Review
- Development and functional adaptation of intestinal macrophages across the lifespan.Clinical & translational immunology · 2026Review
- The plasticity and metabolic reprogramming of macrophage in ulcerative colitis.Frontiers in immunology · 2026Review
- MyD88-mediated signaling in intestinal fibroblasts regulates macrophage antimicrobial defense and prevents dysbiosis in the gut.Cell reports · 2025Article
- Mechanisms conferring multi-layered protection against intestinal Salmonella Typhimurium infection.FEMS microbiology reviews · 2025Review
- Macrophage transfer promotes intestinal mucosal healing by encouraging transit-amplifying cell expansion in mice.Frontiers in immunology · 2025Article
- Focusing on the interplay between tumor-associated macrophages and tumor microenvironment: from mechanism to intervention.Theranostics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
40 authors at 6 institutions in 3 countries.
Egle KvedaraiteCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. egle.kvedaraite@ki.se.ORCID 0000-0001-5308-092X
Magda LourdaCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0003-3155-1123
Natalia MouratidouPediatric Gastroenterology, Hepatology and Nutrition Unit, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
Tim DükingMiltenyi Biotec B.V. & Co. KG, Bergisch Gladbach, Germany.ORCID 0000-0002-4347-7648
Avinash PadhiCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Kirsten MollCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Paulo CzarnewskiScience for Life Laboratory, Department of Biochemistry and Biophysics and National Bioinformatics Infrastructure Sweden, Stockholm University, Solna, Sweden.
Indranil SinhaChildhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-2513-5927
Ioanna XagorarisDepartment of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden.
Efthymia KokkinouCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Anastasios DamdimopoulosBioinformatics and Expression Analysis Core Facility, Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
Whitney WeigelCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Olga HartwigMiltenyi Biotec B.V. & Co. KG, Bergisch Gladbach, Germany.ORCID 0000-0001-5016-5960
Telma E SantosMiltenyi Biotec B.V. & Co. KG, Bergisch Gladbach, Germany.
Tea SoiniCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Aline Van AckerCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Nelly RahkonenIntegrated Cardio Metabolic Centre, Department of Medicine Huddinge, Karolinska Institutet, Huddinge, Sweden.
Malin Flodström TullbergCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0003-2685-2052
Emma RingqvistCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Marcus BuggertCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0003-0633-1719
Carl JornsDepartment of Transplantation Surgery, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0001-7727-8113
Ulrik LindforssDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Caroline NordenvallDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Christopher T StamperCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
David Unnersjö-JessScience for Life Laboratory, Dept. of Applied Physics, Royal Institute of Technology, Solna, Sweden.ORCID 0000-0002-4162-0973
Mira AkberCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Ruta NadisauskaiteCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Jessica JanssonPediatric Gastroenterology, Hepatology and Nutrition Unit, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
Niels VandammeVIB Single Cell Core, VIB, Ghent, Belgium.
Chiara SoriniImmunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institutet and University Hospital, Stockholm, Sweden.ORCID 0000-0002-6803-8377
Marijke Elise GrundekenDivision of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-6915-0339
Helena RolandsdotterDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
George RassidakisDepartment of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden.
Eduardo J VillablancaImmunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institutet and University Hospital, Stockholm, Sweden.ORCID 0000-0001-9522-9729
Maja IdeströmPediatric Gastroenterology, Hepatology and Nutrition Unit, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
Stefan EulitzMiltenyi Biotec B.V. & Co. KG, Bergisch Gladbach, Germany.
Henrik ArnellPediatric Gastroenterology, Hepatology and Nutrition Unit, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
Jenny MjösbergCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0002-1119-0976
Jan-Inge HenterChildhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-0629-2126
Mattias SvenssonCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. mattias.svensson@ki.se.ORCID 0000-0003-1695-7934
Karolinska University Hospital · SEKarolinska Institutet · SEMiltenyi Biotec (Germany) · DEScience for Life Laboratory · SEStockholm University · SEVIB-UGent Center for Inflammation Research · BE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stromal cells support epithelial cell and immune cell homeostasis and play an important role in inflammatory bowel disease (IBD) pathogenesis. Here, we quantify the stromal response to inflammation in pediatric IBD and reveal subset-specific inflammatory responses across colon segments and intestinal layers. Using data from a murine dynamic gut injury model and human ex vivo transcriptomic, protein and spatial analyses, we report that PDGFRA
Indexed as
Inflammatory Bowel DiseasesMonocytesAnimalsCell DifferentiationChildGranulocyte-Macrophage Colony-Stimulating FactorHumansInflammationMacrophagesMiceGranulocyte-Macrophage Colony-Stimulating Factor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.