Evidence map›Paper›PMID 38409083›Full record

ArticleNature communications2024

A wireless battery-free eye modulation patch for high myopia therapy.

Tianyan Zhong, Hangjin Yi, Jiacheng Gou, Jie Li, Miao Liu, Xing Gao, Sizhu Chen, Hongye Guan, Shan Liang, Qianxiong He and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Electrical Microneedles for Wound Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  11. Article
  12. Emerging Wearable Acoustic Sensing Technologies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  13. Advances in clinical applications of microneedle.Frontiers in pharmacology · 2025
    Review
  14. Review
  15. Article
  16. Retinal glia in myopia: current understanding and future directions.Frontiers in cell and developmental biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 2 countries.

Tianyan ZhongSchool of Physics, University of Electronic Science and Technology of China, Chengdu, 611731, China.ORCID 0000-0001-5516-1440
Hangjin YiSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Jiacheng GouSchool of Information and Communication Engineering, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Jie LiDepartment of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Miao LiuDepartment of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Xing GaoDepartment of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Sizhu ChenDepartment of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Hongye GuanSchool of Physics, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Shan LiangSchool of Physics, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Qianxiong HeSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Rui LinSchool of Physics, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Zhihe LongDepartment of Mechanical Engineering, City University of Hong Kong, Hong Kong SAR, 999077, China.ORCID 0000-0003-3815-2029
Yue WangSchool of Information and Communication Engineering, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Chuang ShiSchool of Information and Communication Engineering, University of Electronic Science and Technology of China, Chengdu, 611731, China.ORCID 0000-0002-1517-2775
Yang ZhanBrain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.ORCID 0000-0002-1150-6344
Yan ZhangSchool of Physics, University of Electronic Science and Technology of China, Chengdu, 611731, China.ORCID 0000-0002-7329-0382
Lili XingSchool of Physics, University of Electronic Science and Technology of China, Chengdu, 611731, China.ORCID 0000-0003-1650-0686
Jie ZhongSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, 610054, China. zhongjie@med.uestc.edu.cn.ORCID 0000-0003-0833-995X
Xinyu XueSchool of Physics, University of Electronic Science and Technology of China, Chengdu, 611731, China. xuexinyu@uestc.edu.cn.ORCID 0000-0003-1379-6813
University of Electronic Science and Technology of China · CNChinese Academy of Sciences · CNCity University of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The proper axial length of the eye is crucial for achieving emmetropia. In this study, we present a wireless battery-free eye modulation patch designed to correct high myopia and prevent relapse. The patch consists of piezoelectric transducers, an electrochemical micro-actuator, a drug microneedle array, μ-LEDs, a flexible circuit, and biocompatible encapsulation. The system can be wirelessly powered and controlled using external ultrasound. The electrochemical micro-actuator plays a key role in precisely shortening the axial length by driving the posterior sclera inward. This ensures accurate scene imaging on the retina for myopia eye. The drug microneedle array delivers riboflavin to the posterior sclera, and μ-LEDs' blue light induces collagen cross-linking, reinforcing sclera strength. In vivo experiments demonstrate that the patch successfully reduces the rabbit eye's axial length by ~1217 μm and increases sclera strength by 387%. The system operates effectively within the body without the need for batteries. Here, we show that the patch offers a promising avenue for clinically treating high myopia.

Indexed as

MyopiaAnimalsCross-Linking ReagentsDisease Models, AnimalRabbitsRiboflavinScleraCross-Linking ReagentsRiboflavin

Identifiers

PMID38409083
PMCPMC10897479
OpenAlexW4392167099

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.