ArticleGenome biology2024
Precise fine-turning of GhTFL1 by base editing tools defines ideal cotton plant architecture.
Article in Genome biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 35 citations in OpenAlex.
- CRISPR/Cas9-mediated editing of theGM crops & food · 2026Article
- Harnessing polyploidy for climate-resilient crops: Lessons from the evolutionary model, allotetraploid cotton.Proceedings of the National Academy of Sciences of the United States of America · 2026Review
- Article
- Engineering TadA8e-based base editors for GhWOX1 editing to create cotton with diverse leaf shapes.Science China. Life sciences · 2026Article
- Engineering crop determinacy: CRISPR/Cas based advances in self-pruning gene function and application.Molecular biology reports · 2026Review
- Cas9-Embedding Hyperactive TadA8e Confers Efficient and Highly Specific A-To-G Base Editing in Rice.Plant biotechnology journal · 2026Article
- Review
- Speed breeding in upland cotton (Frontiers in plant science · 2026Review
- Evolution and Future Directions in Herbicide-Resistant Crop Development and Weed Management.Rice (New York, N.Y.) · 2025Review
- Double-stranded DNA deaminase DddAGenome biology · 2025Article
- Genome assembly of two allotetraploid cotton germplasms reveals mechanisms of somatic embryogenesis and enables precise genome editing.Nature genetics · 2025Article
- Enhancing Specificity, Precision, Accessibility, Flexibility, and Safety to Overcome Traditional CRISPR/Cas Editing Challenges and Shape Future Innovations.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Genetic dissection of lint percentage in an introgression population between Gossypium hirsutum and G. mustelinum.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Virus-induced systemic and heritable gene editing in pepper (Capsicum annuum L.).The Plant journal : for cell and molecular biology · 2025Article
- RNA Interference-Mediated Suppression ofBiology · 2025Article
- A comprehensive all-in-one CRISPR toolbox for large-scale screens in plants.The Plant cell · 2025Article
- Genome-wide identification unravels the role of the arabinogalactan peptide (AGP) gene family in cotton plant architecture.Plant cell reports · 2025Article
- Unlocking Nature's Shield: The Promising Potential of CRISPRa in Amplifying Antimicrobial Peptide Expression in Common Bean (ACS omega · 2025Article
- CRISPR/Cas9: a sustainable technology to enhance climate resilience in major Staple Crops.Frontiers in genome editing · 2025Review
- Genome-Wide Identification and Analysis of theGenes · 2024Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCRISPR/Cas-derived base editor enables precise editing of target sites and has been widely used for basic research and crop genetic improvement. However, the editing efficiency of base editors at different targets varies greatly.
resultsHere, we develop a set of highly efficient base editors in cotton plants. GhABE8e, which is fused to conventional nCas9, exhibits 99.9% editing efficiency, compared to GhABE7.10 with 64.9%, and no off-target editing is detected. We further replace nCas9 with dCpf1, which recognizes TTTV PAM sequences, to broaden the range of the target site. To explore the functional divergence of TERMINAL FLOWER 1 (TFL1), we edit the non-coding and coding regions of GhTFL1 with 26 targets to generate a comprehensive allelic population including 300 independent lines in cotton. This allows hidden pleiotropic roles for GhTFL1 to be revealed and allows us to rapidly achieve directed domestication of cotton and create ideotype germplasm with moderate height, shortened fruiting branches, compact plant, and early-flowering. Further, by exploring the molecular mechanism of the GhTFL1
conclusionsThis strategy provides an important technical platform and genetic information for the study and creation of ideal plant architecture.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.