Evidence map›Paper›PMID 38408775›Full record

ArticleRespiratory care2024

Effects of Lung Injury and Abdominal Insufflation on Respiratory Mechanics and Lung Volume During Time-Controlled Adaptive Ventilation.

Harry Ramcharran, Gregory Wetmore, Scott Cooper, Jacob Herrmann, Andrea Fonseca da Cruz, David W Kaczka, Joshua Satalin, Sarah Blair, Penny L Andrews, Nader M Habashi and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Harry RamcharranDepartment of Surgery, SUNY Upstate Medical University, Syracuse, New York.
Gregory WetmoreDepartment of Surgery, University of Cincinnati, Cincinnati, Ohio.
Scott CooperDepartment of Internal Medicine, Morehouse School of Medicine, Atlanta, Georgia.
Jacob HerrmannRoy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa.
Andrea Fonseca da CruzDepartment of Anesthesia, University of Iowa, Iowa City, Iowa.
David W KaczkaRoy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa; Department of Anesthesia, University of Iowa, Iowa City, Iowa; and Department of Radiology, University of Iowa, Iowa City, Iowa.
Joshua SatalinDepartment of Surgery, SUNY Upstate Medical University, Syracuse, New York.
Sarah BlairDepartment of Surgery, SUNY Upstate Medical University, Syracuse, New York.
Penny L AndrewsDepartment of Trauma Critical Care Medicine, R Adams Cowley Shock Trauma Center, University of Maryland Medical Center, Baltimore, Maryland.
Nader M HabashiDepartment of Trauma Critical Care Medicine, R Adams Cowley Shock Trauma Center, University of Maryland Medical Center, Baltimore, Maryland.
Gary F NiemanDepartment of Surgery, SUNY Upstate Medical University, Syracuse, New York.
Michaela Kollisch-SinguleDepartment of Surgery, SUNY Upstate Medical University, Syracuse, New York. KolliscM@upstate.edu.
SUNY Upstate Medical University · USUniversity of Iowa · USUniversity of Maryland, Baltimore · USMorehouse School of Medicine · USUniversity of Cincinnati · US

Funding

HOST RESPONSE TO TRAUMA RESEARCH TRAINING PROGRAMT32GM008478 · NIGMS · UNIVERSITY OF CINCINNATI · PI TIMOTHY A PRITTS, BASILIA ZINGARELLI · 1993 to 2026
$6.7M
Preserving Epithelial Barrier Integrity in Ventilator-Induced Lung InjuryR01HL142702 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Jason HT Bates, DONALD P. GAVER · 2018 to 2026
$4.6M
NHLBI NIH HHS R01 HL142702NIGMS NIH HHS T32 GM008478
6 · The paper itself

Abstract

backgroudLung volume measurements are important for monitoring functional aeration and recruitment and may help guide adjustments in ventilator settings. The expiratory phase of airway pressure release ventilation (APRV) may provide physiologic information about lung volume based on the expiratory flow-time slope, angle, and time to approach a no-flow state (expiratory time [T

methodsEight pigs (35.2 ± 1.0 kg) were mechanically ventilated using an Engström Carescape R860 on the APRV mode. All settings were held constant except the expiratory duration, which was adjusted based on the expiratory flow curve. Abdominal pressure was increased to 15 mm Hg in normal and injured lungs to replicate a combination of pulmonary and extrapulmonary lung injury. ELV was estimated using the Carescape FRC INview tool. The expiratory flow-time slope and T

resultsLung elastance increased with induced lung injury from 29.3 ± 7.3 cm H

conclusionsChanges in ELV over time, and the T

Indexed as

InsufflationLungLung InjuryLung Volume MeasurementsRespiration, ArtificialRespiratory MechanicsAbdomenAnimalsDisease Models, AnimalExhalationSwineTidal Volumeairway pressure release ventilationend-expiratory lung volumeexpiratory flowtime-controlled adaptive ventilation

Identifiers

PMID38408775
PMCPMC11549635
OpenAlexW4392162913

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.