Evidence map›Paper›PMID 38408669›Full record

ArticleThe Science of the total environment2024

Prenatal exposure to polybrominated diphenyl ether (PBDE) and child neurodevelopment: The role of breastfeeding duration.

Jordyn T Wallenborn, Carly Hyland, Sharon K Sagiv, Katherine R Kogut, Asa Bradman, Brenda Eskenazi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Science of the total environment, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Microplastics and Nanoplastics in Food: Dietary Toxicology Beyond Particle Counts.Comprehensive reviews in food science and food safety · 2026
    Review
  2. Article
  3. Early-life NOThe Lancet regional health. Western Pacific · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Jordyn T WallenbornCenter of Excellence for Maternal and Child Health, School of Public Health, University of California, Berkeley, CA, USA; Swiss Tropical and Public Health Institute, Department of Epidemiology and Public Health, Basel, Switzerland; University of Basel, Basel, Switzerland. Electronic address: jordyn.wallenborn@swisstph.ch.
Carly HylandDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA; Division of Agriculture and Natural Resources, University of California, Berkeley, CA, USA; Center for Environmental Research and Community Health (CERCH), School of Public Health, University of California, Berkeley, CA, USA.
Sharon K SagivCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, Berkeley, CA, USA.
Katherine R KogutCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, Berkeley, CA, USA.
Asa BradmanDepartment of Public Health, School of Social Sciences, Humanities, and Arts, University of California, Merced, USA.
Brenda EskenaziCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, Berkeley, CA, USA.
Center for Environmental Health · USSwiss Tropical and Public Health Institute · CHUniversity of California, Merced · US

Funding

Project C: Epigenetic Effects of DDT/E and PBDEs on PubertyP01ES009605 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 1999 to 2015
$11.2M
PBDEs, DDT and Neurodevelopment in School-Aged Mexican-American ChildrenR01ES015572 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 2007 to 2010
$2.0M
Fostering Scientific and Workforce Diversity by Maintaining and Enriching the CHAMACOS Birth CohortU24ES028529 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI GUNIER, ROBERT · 2023 to 2025
$1.1M
NIEHS NIH HHS P01 ES009605NIEHS NIH HHS R01 ES015572NIEHS NIH HHS U24 ES028529
6 · The paper itself

Abstract

backgroundPrenatal and early-life exposure to polybrominated diphenyl ethers (PBDEs) is associated with detrimental and irreversible neurodevelopmental health outcomes during childhood. Breastfeeding may be a child's largest sustained exposure to PBDE- potentially exacerbating their risk for adverse neurodevelopment outcomes. However, breastfeeding has also been associated with positive neurodevelopment. Our study investigates if breastfeeding mitigates or exacerbates the known adverse effects of prenatal exposure to PBDEs and child neurodevelopment.

methodsParticipants included 321 mother-infant dyads from the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS), a longitudinal birth cohort in California. PBDE concentrations were measured in maternal serum blood samples collected during pregnancy or at delivery. Using generalized estimated equations (GEE), we estimated associations of PBDE concentrations with children's attention, executive function, and cognitive scores assessed longitudinally between 7 and 12 years of age, stratified by duration of exclusive and complementary breastfeeding.

resultsWe observed that higher maternal prenatal PBDE concentrations were associated with poorer executive function among children who were complementary breastfed for a shorter duration compared to children breastfed for a longer duration; preservative errors (β for 10-fold increase in complementary breastfeeding <7 months = -6.6; 95 % Confidence Interval (CI): -11.4, -1.8; β ≥ 7 months = -5.1; 95 % CI: -10.2, 0.1) and global executive composition (β for 10-fold increase <7 months = 4.3; 95 % CI: 0.4, 8.2; β for 10-fold increase ≥7 months = 0.6; 95 % CI: -2.8, 3.9).

conclusionsProlonged breastfeeding does not exacerbate but may mitigate some previously observed negative associations of prenatal PBDE exposure and child neurodevelopment.

Indexed as

Halogenated Diphenyl EthersPrenatal Exposure Delayed EffectsBreast FeedingChildExecutive FunctionFemaleHumansInfantMaternal ExposurePregnancyHalogenated Diphenyl Etherspentabromodiphenyl etherBreastfeedingLactationNeurodevelopmentPolybrominated diphenyl ethers

Identifiers

PMID38408669
PMCPMC11070443
OpenAlexW4392133583

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.