Evidence map›Paper›PMID 38408523›Full record

Trial reportBehavioural brain research2024

Effects of cortisol administration on heart rate variability and functional connectivity across women with different depression histories.

Carissa L Philippi, Emily Weible, Alissa Ehlers, Erin C Walsh, Roxanne M Hoks, Rasmus M Birn, Heather C Abercrombie

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Behavioural brain research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Carissa L PhilippiDepartment of Psychological Sciences, University of Missouri-St. Louis, 1 University Blvd, St. Louis, MO 63121, USA. Electronic address: philippic@umsl.edu.
Emily WeibleDepartment of Psychological Sciences, University of Missouri-St. Louis, 1 University Blvd, St. Louis, MO 63121, USA.
Alissa EhlersDepartment of Psychiatry, University of Wisconsin-Madison, University of Wisconsin-Madison, 6001 Research Park Blvd, Madison, WI 53719, USA.
Erin C WalshDepartment of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, CB# 7167, Chapel Hill, NC 27599, USA.
Roxanne M HoksDepartment of Psychiatry, University of Wisconsin-Madison, University of Wisconsin-Madison, 6001 Research Park Blvd, Madison, WI 53719, USA; Center for Healthy Minds, University of Wisconsin-Madison., 625 W. Washington Ave, Madison, WI 53703, USA.
Rasmus M BirnDepartment of Psychiatry, University of Wisconsin-Madison, University of Wisconsin-Madison, 6001 Research Park Blvd, Madison, WI 53719, USA.
Heather C AbercrombieDepartment of Psychiatry, University of Wisconsin-Madison, University of Wisconsin-Madison, 6001 Research Park Blvd, Madison, WI 53719, USA; Center for Healthy Minds, University of Wisconsin-Madison., 625 W. Washington Ave, Madison, WI 53703, USA.

Funding

Learning, neural signaling of cortisol, and early adversity in depressionR01MH094478 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI ABERCROMBIE, HEATHER C · 2012 to 2016
$2.2M
Neuroinflammatory Mechanisms of Anhedonia in Major DepressionK23MH113733 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WALSH, ERIN · 2018 to 2023
$866k
NIMH NIH HHS K23 MH113733NIMH NIH HHS R01 MH094478
6 · The paper itself

Abstract

Abnormalities within the hypothalamic-pituitary-adrenal (HPA) axis and autonomic nervous system have been implicated in depression. Studies have reported glucocorticoid insensitivity and reduced heart rate variability (HRV) in depressive disorders. However, little is known about the effects of cortisol on HRV and resting-state functional connectivity (rsFC) of the central autonomic network (CAN) in depression. We collected resting-state fMRI and cardiac data for women with different depression histories (n = 61) after administration of cortisol and placebo using a double-blind crossover design. We computed rsFC for R-amygdala and L-amygdala seeds and assessed the change in HRV after cortisol (cortisol-placebo). Analyses examined the effects of acute cortisol administration on HRV and rsFC of the R-amygdala and L-amygdala. There was a significant interaction between HRV and treatment for rsFC between the amygdala and CAN regions. We found lower rsFC between the L-amygdala and putamen for those with a greater decrease in HRV after cortisol. There was also reduced rsFC between the R-amygdala and dorsomedial prefrontal cortex, putamen, middle cingulate cortex, insula, and cerebellum in those with lower HRV after cortisol. These results remained significant after adjusting for depression symptoms, age, and race. Our findings suggest that the effect of cortisol on CAN connectivity is related to its effects on HRV. Overall, these results could inform transdiagnostic interventions targeting HRV and the stress response systems across clinical and non-clinical populations.

Indexed as

DepressionHydrocortisoneFemaleGyrus CinguliHeart RateHumansMagnetic Resonance ImagingPrefrontal CortexHydrocortisoneAmygdalaCentral autonomic networkCortisolDepressionHeart rate variabilityResting-state functional connectivity

Identifiers

PMID38408523
PMCPMC10942667

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.