Evidence map›Paper›PMID 38408488›Full record

ArticleNature2024

Automated model building and protein identification in cryo-EM maps.

Kiarash Jamali, Lukas Käll, Rui Zhang, Alan Brown, Dari Kimanius, Sjors H W Scheres

Abstract readComparative Study
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 471 papers.

0numbers the graph read from it
0cells of the map it votes in
471citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

471 citing papers in PubMed.

  1. High resolution cryo-EM structure of theJournal of structural biology: X · 2026
    Article
  2. MultilevelCurrent research in structural biology · 2026
    Article
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  13. Diversity of electron-bifurcating COScience advances · 2026
    Article
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  20. Review

411 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Kiarash JamaliMRC Laboratory of Molecular Biology, Cambridge, UK. kjamali@mrc-lmb.cam.ac.uk.ORCID 0009-0008-4805-9518
Lukas KällScience for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden.ORCID 0000-0001-5689-9797
Rui ZhangWashington University in St Louis, St Louis, MO, USA.ORCID 0000-0003-3159-9565
Alan BrownBlavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0021-0476
Dari KimaniusMRC Laboratory of Molecular Biology, Cambridge, UK. dari@mrc-lmb.cam.ac.uk.
Sjors H W ScheresMRC Laboratory of Molecular Biology, Cambridge, UK. scheres@mrc-lmb.cam.ac.uk.ORCID 0000-0002-0462-6540

Funding

Mechanoregulation of Ciliary MotilityR01GM141109 · NIGMS · HARVARD MEDICAL SCHOOL · PI BROWN, ALAN · 2021 to 2025
$2.1M
Structural and functional studies of axonemal microtubule inner proteins (MIPs)R01GM138854 · NIGMS · WASHINGTON UNIVERSITY · PI ZHANG, RUI · 2020 to 2024
$2.0M
Medical Research Council MC_UP_A025_1013NIGMS NIH HHS R01 GM138854NIGMS NIH HHS R01 GM141109
6 · The paper itself

Abstract

Interpreting electron cryo-microscopy (cryo-EM) maps with atomic models requires high levels of expertise and labour-intensive manual intervention in three-dimensional computer graphics programs

Indexed as

Cryoelectron MicroscopyMachine LearningModels, MolecularProteinsAmino Acid SequenceComputer GraphicsMarkov ChainsNeural Networks, ComputerProtein ConformationProteins

Identifiers

PMID38408488
PMCPMC11006616

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.