ArticleNature2024
A patterned human neural tube model using microfluidic gradients.
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Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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74citing papers in PubMed
18.8field-weighted citation impact, top 1% of its field
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Who cites it
74 citing papers in PubMed, 102 citations in OpenAlex.
- Engineering human multi-organ tissue chip niches for drug absorption, distribution, metabolism, excretion and toxicity prediction.Nature biomedical engineering · 2026Review
- Overcoming diffusion limits to advance brain organoids.Neural regeneration research · 2026Article
- Organoids: Key advances, optimization, and technological iterations in their application to neurodegenerative diseases.Neural regeneration research · 2026Article
- hiPSC-derived Organoids and Organ-on-chip Systems: New Frontiers in Neural Tube Defect Research.Stem cell reviews and reports · 2026Review
- Acoustic cell patterning reveals geometry- and substrate-dependent vasculogenesis and human embryo model development.Nature communications · 2026Article
- Organoids-on-a-Chip: An Integrating New Technology for Drug Development.International journal of molecular sciences · 2026Review
- Neurabin I haploinsufficiency disrupts ion channel regulation and synaptic maturation in human cortical neurons in neurodevelopmental disorders.Molecular psychiatry · 2026Article
- Emerging Regenerative Medicine for Spinal Cord Injury: Spinal Cord Organoids-on-a-Chip.International journal of molecular sciences · 2026Review
- Advances and applications of brain organoids in central nervous system disorders: Bridging the gap from laboratory to clinic.Neural regeneration research · 2026Article
- Next-Generation Strategies for Neural Repair and Regeneration: Neural Organoid Transplantation in the CNS.Cell proliferation · 2026Review
- Spatially defined axonal guidance in neural organoids with micropatterned microfluidic channels.bioRxiv : the preprint server for biology · 2026Article
- A transgene-free, human peri-gastrulation embryo model presents trilaminar embryonic disc-, amnion- and yolk sac-like structures.Nature cell biology · 2026Article
- Self-organized anteroposterior regionalization of early midbrain and hindbrain/spinal cords using micropatterned human pluripotent stem cells.SLAS technology · 2026Article
- Microfluidic Control of Dorsal-Ventral Patterning Within a Single Forebrain Organoid.bioRxiv : the preprint server for biology · 2026Article
- Article
- A bioinspired anisotropic anti-inflammatory scaffold enhances spinal nerve regeneration and neural circuit reconstruction via FGF13/CaMaterials today. Bio · 2026Article
- Microfluidic gradients create a stem cell model of the human central nervous system.Nature protocols · 2026Article
- Generation of spatially patterned human neural tube-like structures using microfluidic gradient devices.Nature protocols · 2026Review
- A controllable human spinal cord model with full dorsoventral patterning.Nature communications · 2026Article
- Organoids: technology refining, current applications and future directions.Molecular biomedicine · 2026Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 4 institutions in 3 countries.
Xufeng XueDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-9379-8589
Yung Su KimDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.
Alfredo-Isaac Ponce-AriasDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0001-6587-2983
Richard O'LaughlinDepartment of Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0002-7552-5421
Robin Zhexuan YanDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-2974-2249
Norio KobayashiDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.
Rami Yair TshuvaDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Yu-Hwai TsaiDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI, USA.
Shiyu SunDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.
Yi ZhengDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-2685-3680
Yue LiuDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-3153-6962
Frederick C K WongWellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.
Azim SuraniWellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.ORCID 0000-0002-8640-4318
Jason R SpenceDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0001-7869-3992
Hongjun SongDepartment of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-8720-5310
Guo-Li MingDepartment of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-2517-6075
Orly ReinerDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0001-7560-9599
Jianping FuDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA. jpfu@umich.edu.ORCID 0000-0001-9629-6739
University of Michigan · USWeizmann Institute of Science · ILUniversity of Cambridge · GBCalifornia Institute for Regenerative Medicine · US
Funding
Continuous Neurogenesis in the Mammalian HippocampusR35NS116843 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI HONGJUN SONG · 2020 to 2026
$6.9MFunctional roles of genetic risk factors for brain disorders in neurogenesis and neurodevelopmentR35NS097370 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MING, GUO-LI · 2017 to 2024
$6.7MA Fully Patterned Human Neural Tube Model Using MicrofluidicsR01NS129850 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jianping Fu · 2023 to 2026
$2.1MAcoustic Tweezing Cytometry for Efficient Neural DifferentiationR01GM143297 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DENG, CHERI X, FU, JIANPING · 2021 to 2024
$1.8MSliced human neocortical organoids for modeling cortical laminar and columnar organization and functionRF1MH123979 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI MING, GUO-LI · 2020 to 2020
$1.7MSynthetic microfluidic synthesis of spinal cord tissues from human pluripotent stem cellsR21NS113518 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FU, JIANPING · 2019 to 2019
$422kAmnion membrane organ-on-chip for modeling intra-amniotic infectionR21HD105192 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FU, JIANPING, ZHENG, YI · 2022 to 2023
$397kModeling NDE1 function in dysregulated brain development using a microfluidic CNS modelR21NS127983 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FU, JIANPING, REINER, ORLY · 2023 to 2024
$371kControlled generation of human embryoids using optogeneticsR21HD109635 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FU, JIANPING · 2022 to 2023
$336kNICHD NIH HHS R21 HD105192NICHD NIH HHS R21 HD109635NIGMS NIH HHS R01 GM143297NIMH NIH HHS RF1 MH123979NINDS NIH HHS R01 NS129850NINDS NIH HHS R21 NS113518NINDS NIH HHS R21 NS127983NINDS NIH HHS R35 NS097370NINDS NIH HHS R35 NS116843
Abstract
The human nervous system is a highly complex but organized organ. The foundation of its complexity and organization is laid down during regional patterning of the neural tube, the embryonic precursor to the human nervous system. Historically, studies of neural tube patterning have relied on animal models to uncover underlying principles. Recently, models of neurodevelopment based on human pluripotent stem cells, including neural organoids
Indexed as
Body PatterningMicrofluidicsNeural TubeCDX2 Transcription FactorCell Culture Techniques, Three DimensionalCell DifferentiationHumansNeural CrestPluripotent Stem CellsProsencephalonSpinal CordCDX2 protein, humanCDX2 Transcription Factor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.