Evidence map›Paper›PMID 38408423›Full record

ArticleCarbohydrate research2024

Synthesis of a unique mannose α-1-phosphate side chain moiety found in Candida auris cell wall mannan.

Zuchao Ma, Harry E Ensley, Bridget Graves, Michael D Kruppa, Peter J Rice, Douglas W Lowman, David L Williams

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Carbohydrate research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Microbiology and molecular biology reviews : MMBR · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zuchao MaDepartments of Surgery, East Tennessee State University, Johnson City, TN, USA; Drug Discovery and Synthesis Core, East Tennessee State University, Johnson City, TN, USA; Center for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA. Electronic address: maz001@etsu.edu.
Harry E EnsleyDepartments of Surgery, East Tennessee State University, Johnson City, TN, USA; Drug Discovery and Synthesis Core, East Tennessee State University, Johnson City, TN, USA; Center for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.
Bridget GravesDepartments of Surgery, East Tennessee State University, Johnson City, TN, USA; Center for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.
Michael D KruppaBiomedical Sciences, East Tennessee State University, Johnson City, TN, USA; Center for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.
Peter J RiceCenter for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA; Department of Clinical Pharmacy, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA.
Douglas W LowmanDepartments of Surgery, East Tennessee State University, Johnson City, TN, USA; Drug Discovery and Synthesis Core, East Tennessee State University, Johnson City, TN, USA; Center for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.
David L WilliamsDepartments of Surgery, East Tennessee State University, Johnson City, TN, USA; Drug Discovery and Synthesis Core, East Tennessee State University, Johnson City, TN, USA; Center for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.
East Tennessee State University · US

Funding

Training Innate Immunity: A new approach to the treatment of SepsisR01GM119197 · NIGMS · EAST TENNESSEE STATE UNIVERSITY · PI SHERWOOD, EDWARD R, WILLIAMS, DAVID L. · 2016 to 2024
$4.6M
Innate Immunity and Cardiovascular Function in SepsisR01GM083016 · NIGMS · EAST TENNESSEE STATE UNIVERSITY · PI LI, CHUANFU, WILLIAMS, DAVID L. · 2009 to 2021
$3.8M
Development of an alpha-1 phosphate mannan vaccine against the emerging fungal pathogen Candida auris.R21AI173607 · NIAID · EAST TENNESSEE STATE UNIVERSITY · PI WILLIAMS, DAVID L. · 2023 to 2024
$413k
Genetic Characterization of phosphomannan biosynthesis in C. aurisR21AI159877 · NIAID · EAST TENNESSEE STATE UNIVERSITY · PI KRUPPA, MICHAEL D · 2021 to 2022
$407k
NIAID NIH HHS R21 AI159877NIAID NIH HHS R21 AI173607NIGMS NIH HHS R01 GM083016NIGMS NIH HHS R01 GM119197
6 · The paper itself

Abstract

Candida auris is an emerging fungal pathogen that has become a world-wide public health threat. While there have been numerous studies into the nature, composition and structure of the cell wall of Candida albicans and other Candida species, much less is known about the C. auris cell wall. We have shown that C. auris cell wall mannan contains a unique phosphomannan structure which distinguishes C. auris mannan from the mannans found in other fungal species. Specifically, C. auris exhibits two unique acid-labile mannose α-1-phosphate (Manα1PO

Indexed as

MannansVaccinesCandida albicansCandida aurisCell WallMannosePhosphatesReceptors, Cell SurfaceMannansMannosePhosphatesReceptors, Cell SurfaceVaccinesCandida aurisGlycomimeticMannose α-1-phosphate (Manα1PO(4))PhosphomannanReceptor bindingStructural analysis

Identifiers

PMID38408423
PMCPMC10957239
OpenAlexW4391986537

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.